Outcome of idiopathic membranoproliferative glomerulonephritis in children. Arbeitsgemeinschaft Pädiatrische Nephrologie
The aim of this multicentre study was to analyse the long-term outcome of idiopathic membranoproliferative glomerulonephritis (MPGN) according to histological type and to the presence of C3 nephritic factor. Fifty patients aged 2-14 years at the onset of the study were followed over 2-20 years; 26 p...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1996
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| In: |
Acta paediatrica
Year: 1996, Jahrgang: 85, Heft: 3, Pages: 308-312 |
| ISSN: | 1651-2227 |
| DOI: | 10.1111/j.1651-2227.1996.tb14022.x |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1111/j.1651-2227.1996.tb14022.x Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1651-2227.1996.tb14022.x 
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| Verfasserangaben: | R. Schwertz, R. de Jong, N. Gretz, M. Kirschfink, D. Anders, K. Schärer and Arbeitsgemeinschaft Pädiatrische Nephrologie |
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| 245 | 1 | 0 | |a Outcome of idiopathic membranoproliferative glomerulonephritis in children. Arbeitsgemeinschaft Pädiatrische Nephrologie |c R. Schwertz, R. de Jong, N. Gretz, M. Kirschfink, D. Anders, K. Schärer and Arbeitsgemeinschaft Pädiatrische Nephrologie |
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| 520 | |a The aim of this multicentre study was to analyse the long-term outcome of idiopathic membranoproliferative glomerulonephritis (MPGN) according to histological type and to the presence of C3 nephritic factor. Fifty patients aged 2-14 years at the onset of the study were followed over 2-20 years; 26 patients had MPGN type I, 17 had type II and 7 had type III. Treatment was variable. At the last observation, 30 patients had reached terminal and four pre-terminal renal failure. The median survival probability until renal death was 15.3, 8.7 and 15.9 years for disease types I, II and III respectively (difference between MPGN types I + III versus type II: p = 0.013). The presence of an initial nephrotic syndrome was associated with a more rapid progression (p = 0.018). C3 nephritic factor was of no prognostic value. We conclude that the outcome of MPGN mainly depends on the histological type observed. | ||
| 650 | 4 | |a Adolescent | |
| 650 | 4 | |a Child | |
| 650 | 4 | |a Child, Preschool | |
| 650 | 4 | |a Complement C3 Nephritic Factor | |
| 650 | 4 | |a Disease Progression | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Glomerulonephritis, Membranoproliferative | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Kidney | |
| 650 | 4 | |a Kidney Failure, Chronic | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Prognosis | |
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