HBV-infection rate and long-term outcome after liver-transplantation of anti-HBc-positive liver-grafts to HBV-naïve recipients: a retrospective study
Background - Anti-HBc only positive liver grafts may be suitable for HBV-naive recipients insofar as an appropriate infection prophylaxis is performed. Therefore, we investigated the effect of prophylactic regimens on HBV infection prevention and long-term outcome of anti-HBc-positive graft recipien...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 March 2021
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| In: |
Clinics and research in hepatology and gastroenterology
Year: 2021, Jahrgang: 45, Heft: 2, Pages: 1-9 |
| ISSN: | 2210-741X |
| DOI: | 10.1016/j.clinre.2020.07.003 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.clinre.2020.07.003 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2210740120301911 
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| Verfasserangaben: | Daniel Hornuss, Anna Rudi, Lucas Koerner, Isabelle Mohr, Uta Merle, Cyrill Wehling, Christian Rupp, Michael T. Dill, Mohammad Golriz, Paul Schnitzler, Thorsten Brenner, Arianeb Mehrabi, Karl Heinz Weiss, Markus Mieth |
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| 245 | 1 | 0 | |a HBV-infection rate and long-term outcome after liver-transplantation of anti-HBc-positive liver-grafts to HBV-naïve recipients |b a retrospective study |c Daniel Hornuss, Anna Rudi, Lucas Koerner, Isabelle Mohr, Uta Merle, Cyrill Wehling, Christian Rupp, Michael T. Dill, Mohammad Golriz, Paul Schnitzler, Thorsten Brenner, Arianeb Mehrabi, Karl Heinz Weiss, Markus Mieth |
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| 520 | |a Background - Anti-HBc only positive liver grafts may be suitable for HBV-naive recipients insofar as an appropriate infection prophylaxis is performed. Therefore, we investigated the effect of prophylactic regimens on HBV infection prevention and long-term outcome of anti-HBc-positive graft recipients. - Patients and methods - This retrospective monocenter study consisted of a cohort of 1912 patients who underwent deceased donor liver transplantation at our transplant center between June 1987 and July 2019. 81 HBV-naïve patients after reception of an anti-HBc-positive liver-graft and consecutive HBV prophylaxis were selected for further examination. HBV infection rate and host- and graft-survival rates were compared to a matched control group consisting of 162 HBV-naïve patients after reception of anti-HBc-negative grafts. Pharmaceutical HBV prophylaxis included: only HBIG, only NUCs, or combined HBIG and NUCs. - Results - Compared to control cases of HBV-naïve anti-HBc-negative graft recipients, no differences in host- and graft-survival rate were determined.13 of 81 anti-HBc-positive graft recipients (16%) developed HBV-infection after liver transplantation. No patient suffered from HBV infection after receiving modern NUCs. Survival analysis showed no statistical differences between patients with and without infection concerning host- and graft-survival. - Conclusion - Especially in times of organ shortage, anti-HBc-positive liver grafts may be useful for liver transplantation in HBV-naïve recipients. Efficient prophylactic regimens can prevent HBV-infection. | ||
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