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HBV-infection rate and long-term outcome after liver-transplantation of anti-HBc-positive liver-grafts to HBV-naïve recipients: a retrospective study

Background - Anti-HBc only positive liver grafts may be suitable for HBV-naive recipients insofar as an appropriate infection prophylaxis is performed. Therefore, we investigated the effect of prophylactic regimens on HBV infection prevention and long-term outcome of anti-HBc-positive graft recipien...

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Hauptverfasser: Hornuß, Daniel (VerfasserIn) , Rudi, Anna (VerfasserIn) , Koerner, Lucas (VerfasserIn) , Mohr, Isabelle (VerfasserIn) , Merle, Uta (VerfasserIn) , Wehling, Cyrill (VerfasserIn) , Rupp, Christian (VerfasserIn) , Dill, Michael T. (VerfasserIn) , Golriz, Mohammad (VerfasserIn) , Schnitzler, Paul (VerfasserIn) , Brenner, Thorsten (VerfasserIn) , Mehrabi, Arianeb (VerfasserIn) , Weiss, Karl Heinz (VerfasserIn) , Mieth, Markus (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 16 March 2021
In: Clinics and research in hepatology and gastroenterology
Year: 2021, Jahrgang: 45, Heft: 2, Pages: 1-9
ISSN:2210-741X
DOI:10.1016/j.clinre.2020.07.003
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.clinre.2020.07.003
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2210740120301911
Volltext
Verfasserangaben:Daniel Hornuss, Anna Rudi, Lucas Koerner, Isabelle Mohr, Uta Merle, Cyrill Wehling, Christian Rupp, Michael T. Dill, Mohammad Golriz, Paul Schnitzler, Thorsten Brenner, Arianeb Mehrabi, Karl Heinz Weiss, Markus Mieth
Beschreibung
Zusammenfassung:Background - Anti-HBc only positive liver grafts may be suitable for HBV-naive recipients insofar as an appropriate infection prophylaxis is performed. Therefore, we investigated the effect of prophylactic regimens on HBV infection prevention and long-term outcome of anti-HBc-positive graft recipients. - Patients and methods - This retrospective monocenter study consisted of a cohort of 1912 patients who underwent deceased donor liver transplantation at our transplant center between June 1987 and July 2019. 81 HBV-naïve patients after reception of an anti-HBc-positive liver-graft and consecutive HBV prophylaxis were selected for further examination. HBV infection rate and host- and graft-survival rates were compared to a matched control group consisting of 162 HBV-naïve patients after reception of anti-HBc-negative grafts. Pharmaceutical HBV prophylaxis included: only HBIG, only NUCs, or combined HBIG and NUCs. - Results - Compared to control cases of HBV-naïve anti-HBc-negative graft recipients, no differences in host- and graft-survival rate were determined.13 of 81 anti-HBc-positive graft recipients (16%) developed HBV-infection after liver transplantation. No patient suffered from HBV infection after receiving modern NUCs. Survival analysis showed no statistical differences between patients with and without infection concerning host- and graft-survival. - Conclusion - Especially in times of organ shortage, anti-HBc-positive liver grafts may be useful for liver transplantation in HBV-naïve recipients. Efficient prophylactic regimens can prevent HBV-infection.
Beschreibung:Im Titel steht ein Trema über dem "i" bei naïve
Gesehen am 16.06.2021
Beschreibung:Online Resource
ISSN:2210-741X
DOI:10.1016/j.clinre.2020.07.003

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