Cytotoxic natural antibodies against human tumours: an option for anti-cancer immunotherapy?
Healthy individuals may contain in their peripheral blood antibodies which are able to destroy human tumour cells mediated either by complement-dependent cytotoxicity or by apoptosis. The largest proportion of these antibodies is of IgM isotype and directed against distinct tumour associated carbohy...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2008
|
| In: |
Autoimmunity reviews
Year: 2008, Jahrgang: 7, Heft: 6, Pages: 491-495 |
| ISSN: | 1873-0183 |
| DOI: | 10.1016/j.autrev.2008.03.012 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.autrev.2008.03.012 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/abs/pii/S1568997208000402 
|
| Verfasserangaben: | Reinhard Schwartz-Albiez, Simon Laban, Stefan Eichmüller, Michael Kirschfink |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1760897132 | ||
| 003 | DE-627 | ||
| 005 | 20220819235454.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210621s2008 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.autrev.2008.03.012 |2 doi | |
| 035 | |a (DE-627)1760897132 | ||
| 035 | |a (DE-599)KXP1760897132 | ||
| 035 | |a (OCoLC)1341416668 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schwartz-Albiez, Reinhard |e VerfasserIn |0 (DE-588)1112496106 |0 (DE-627)866475532 |0 (DE-576)169948390 |4 aut | |
| 245 | 1 | 0 | |a Cytotoxic natural antibodies against human tumours |b an option for anti-cancer immunotherapy? |c Reinhard Schwartz-Albiez, Simon Laban, Stefan Eichmüller, Michael Kirschfink |
| 264 | 1 | |c 2008 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.06.2021 | ||
| 520 | |a Healthy individuals may contain in their peripheral blood antibodies which are able to destroy human tumour cells mediated either by complement-dependent cytotoxicity or by apoptosis. The largest proportion of these antibodies is of IgM isotype and directed against distinct tumour associated carbohydrate epitopes. Although the origin of these antibodies is not clear they seem to belong to the class of natural antibodies because they are not affinity matured and are encoded by distinct germ-line restricted gene families. It is most likely that this class of natural antibodies has in vivo an anti-tumour protective effect which may contribute to so-called tumour surveillance. On the other hand malignant tumour cells exert mechanisms to counteract such an antibody attack. These comprise soluble factors as well as cell surface expressed membrane complement regulatory proteins (mCRP). Further studies are needed to elucidate molecular mechanisms leading to either tumour destruction induced by natural antibodies or to overcome the protective strategies of the tumour against antibody attack. | ||
| 650 | 4 | |a Antibodies, Neoplasm | |
| 650 | 4 | |a Antigens, Tumor-Associated, Carbohydrate | |
| 650 | 4 | |a Complement Activation | |
| 650 | 4 | |a Cytotoxicity, Immunologic | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Neoplasms | |
| 700 | 1 | |a Laban, Simon Andreas |d 1981- |e VerfasserIn |0 (DE-588)138995524 |0 (DE-627)703174983 |0 (DE-576)309849039 |4 aut | |
| 700 | 1 | |a Eichmüller, Stefan B. |d 1960- |e VerfasserIn |0 (DE-588)1025289226 |0 (DE-627)721986951 |0 (DE-576)37016704X |4 aut | |
| 700 | 1 | |a Kirschfink, Michael |e VerfasserIn |0 (DE-588)120927152 |0 (DE-627)080974457 |0 (DE-576)292452411 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Autoimmunity reviews |d Amsterdam [u.a.] : Elsevier Science, 2002 |g 7(2008), 6, Seite 491-495 |h Online-Ressource |w (DE-627)360312071 |w (DE-600)2099325-0 |w (DE-576)260995614 |x 1873-0183 |7 nnas |a Cytotoxic natural antibodies against human tumours an option for anti-cancer immunotherapy? |
| 773 | 1 | 8 | |g volume:7 |g year:2008 |g number:6 |g pages:491-495 |g extent:5 |a Cytotoxic natural antibodies against human tumours an option for anti-cancer immunotherapy? |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.autrev.2008.03.012 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/abs/pii/S1568997208000402 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210621 | ||
| 993 | |a Article | ||
| 994 | |a 2008 | ||
| 998 | |g 120927152 |a Kirschfink, Michael |m 120927152:Kirschfink, Michael |d 910000 |d 911600 |e 910000PK120927152 |e 911600PK120927152 |k 0/910000/ |k 1/910000/911600/ |p 4 |y j | ||
| 998 | |g 1025289226 |a Eichmüller, Stefan B. |m 1025289226:Eichmüller, Stefan B. |d 140000 |d 60000 |e 140000PE1025289226 |e 60000PE1025289226 |k 0/140000/ |k 0/60000/ |p 3 | ||
| 998 | |g 138995524 |a Laban, Simon |m 138995524:Laban, Simon |p 2 | ||
| 998 | |g 1112496106 |a Schwartz-Albiez, Reinhard |m 1112496106:Schwartz-Albiez, Reinhard |p 1 |x j | ||
| 999 | |a KXP-PPN1760897132 |e 3940343854 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1760897132","physDesc":[{"extent":"5 S."}],"name":{"displayForm":["Reinhard Schwartz-Albiez, Simon Laban, Stefan Eichmüller, Michael Kirschfink"]},"id":{"eki":["1760897132"],"doi":["10.1016/j.autrev.2008.03.012"]},"relHost":[{"disp":"Cytotoxic natural antibodies against human tumours an option for anti-cancer immunotherapy?Autoimmunity reviews","language":["eng"],"note":["Gesehen am 07.01.20"],"origin":[{"dateIssuedDisp":"2002-","publisherPlace":"Amsterdam [u.a.]","publisher":"Elsevier Science","dateIssuedKey":"2002"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title_sort":"Autoimmunity reviews","title":"Autoimmunity reviews"}],"part":{"issue":"6","volume":"7","extent":"5","pages":"491-495","text":"7(2008), 6, Seite 491-495","year":"2008"},"pubHistory":["1.2002 -"],"recId":"360312071","physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["360312071"],"issn":["1873-0183"],"zdb":["2099325-0"]}}],"person":[{"family":"Schwartz-Albiez","display":"Schwartz-Albiez, Reinhard","role":"aut","given":"Reinhard"},{"role":"aut","given":"Simon Andreas","display":"Laban, Simon Andreas","family":"Laban"},{"family":"Eichmüller","display":"Eichmüller, Stefan B.","role":"aut","given":"Stefan B."},{"display":"Kirschfink, Michael","family":"Kirschfink","given":"Michael","role":"aut"}],"language":["eng"],"title":[{"title":"Cytotoxic natural antibodies against human tumours","subtitle":"an option for anti-cancer immunotherapy?","title_sort":"Cytotoxic natural antibodies against human tumours"}],"note":["Gesehen am 21.06.2021"],"origin":[{"dateIssuedDisp":"2008","dateIssuedKey":"2008"}],"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a SCHWARTZALCYTOTOXICN2008 | ||