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Interaction of ambrisentan with clarithromycin and its modulation by polymorphic SLCO1B1

We assessed the effect of cytochrome P450 (CYP) 3A4 and the OATP1B1 inhibitor clarithromycin on ambrisentan steady-state kinetics and its relationship to the SLCO1B1*15 haplotype in healthy volunteers.

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Bibliographic Details
Main Authors: Markert, Christoph (Author) , Hellwig, Regina (Author) , Burhenne, Jürgen (Author) , Hoffmann, Michael Marcus (Author) , Weiß, Johanna (Author) , Mikus, Gerd (Author) , Haefeli, Walter E. (Author)
Format: Article (Journal)
Language:English
Published: 9 June 2013
In: European journal of clinical pharmacology
Year: 2013, Volume: 69, Issue: 10, Pages: 1785-1793
ISSN:1432-1041
DOI:10.1007/s00228-013-1529-1
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00228-013-1529-1
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Author Notes:Christoph Markert, Regina Hellwig, Jürgen Burhenne, Michael Marcus Hoffmann, Johanna Weiss, Gerd Mikus, Walter E. Haefeli

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