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Long term methylphenidate exposure and growth in children and adolescents with ADHD: A systematic review and meta-analysis

Background - Methylphenidate (MPH) is an efficacious treatment for ADHD but concerns have been raised about potential adverse effects of extended treatment on growth. - Objectives - To systematically review the literature, up to December 2018, conducting a meta-analysis of association of long-term (...

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Main Authors: Carucci, Sara (Author) , Balia, Carla (Author) , Gagliano, Antonella (Author) , Lampis, Angelico (Author) , Buitelaar, Jan K. (Author) , Danckaerts, Marina (Author) , Dittmann, Ralf (Author) , Garas, Peter (Author) , Hollis, Chris (Author) , Inglis, Sarah (Author) , Konrad, Kerstin (Author) , Kovshoff, Hanna (Author) , Liddle, Elizabeth B. (Author) , McCarthy, Suzanne (Author) , Nagy, Peter (Author) , Panei, Pietro (Author) , Romaniello, Roberta (Author) , Usala, Tatiana (Author) , Wong, Ian C. K. (Author) , Banaschewski, Tobias (Author) , Sonuga-Barke, Edmund (Author) , Coghill, David (Author) , Zuddas, Alessandro (Author)
Format: Article (Journal)
Language:English
Published: January 2021
In: Neuroscience & biobehavioral reviews
Year: 2021, Volume: 120, Pages: 509-525
ISSN:1873-7528
DOI:10.1016/j.neubiorev.2020.09.031
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neubiorev.2020.09.031
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0149763420305923
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Author Notes:Sara Carucci, Carla Balia, Antonella Gagliano, Angelico Lampis, Jan K. Buitelaar, Marina Danckaerts, Ralf W. Dittmann, Peter Garas, Chris Hollis, Sarah Inglis, Kerstin Konrad, Hanna Kovshoff, Elizabeth B. Liddle, Suzanne McCarthy, Peter Nagy, Pietro Panei, Roberta Romaniello, Tatiana Usala, Ian C. K. Wong, Tobias Banaschewski, Edmund Sonuga-Barke, David Coghill, Alessandro Zuddas
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Summary:Background - Methylphenidate (MPH) is an efficacious treatment for ADHD but concerns have been raised about potential adverse effects of extended treatment on growth. - Objectives - To systematically review the literature, up to December 2018, conducting a meta-analysis of association of long-term (> six months) MPH exposure with height, weight and timing of puberty. - Results - Eighteen studies (ADHD n = 4868) were included in the meta-analysis. MPH was associated with consistent statistically significant pre-post difference for both height (SMD = 0.27, 95% CI 0.16-0.38, p < 0.0001) and weight (SMD = 0.33, 95% CI 0.22-0.44, p < 0.0001) Z scores, with prominent impact on weight during the first 12 months and on height within the first 24-30 months. No significant effects of dose, formulation, age and drug-naïve condition as clinical moderators were found. Data on timing of puberty are currently limited. - Conclusions - Long-term treatment with MPH can result in reduction in height and weight. However, effect sizes are small with possible minimal clinical impact. Long-term prospective studies may help to clarify the underlying biological drivers and specific mediators and moderators.
Item Description:Gesehen am 24.06.2021
Physical Description:Online Resource
ISSN:1873-7528
DOI:10.1016/j.neubiorev.2020.09.031

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