The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra
The Hydra head organizer acts as a signaling center that initiates and maintains the primary body axis in steady state polyps and during budding or regeneration. Wnt/beta-Catenin signaling functions as a primary cue controlling this process, but how Wnt ligand activity is locally restricted at the p...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
09 June 2021
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| In: |
BMC biology
Year: 2021, Volume: 19, Pages: 1-22 |
| ISSN: | 1741-7007 |
| DOI: | 10.1186/s12915-021-01046-9 |
| Online Access: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s12915-021-01046-9 Verlag, kostenfrei, Volltext: https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-01046-9 
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| Author Notes: | Berenice Ziegler, Irene Yiallouros, Benjamin Trageser, Sumit Kumar, Moritz Mercker, Svenja Kling, Maike Fath, Uwe Warnken, Martina Schnölzer, Thomas W. Holstein, Markus Hartl, Anna Marciniak-Czochra, Jörg Stetefeld, Walter Stöcker and Suat Özbek |
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| 520 | |a The Hydra head organizer acts as a signaling center that initiates and maintains the primary body axis in steady state polyps and during budding or regeneration. Wnt/beta-Catenin signaling functions as a primary cue controlling this process, but how Wnt ligand activity is locally restricted at the protein level is poorly understood. Here we report a proteomic analysis of Hydra head tissue leading to the identification of an astacin family proteinase as a Wnt processing factor. | ||
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