Fine tuning and efficient T cell activation with stimulatory aCD3 nanoarrays
Anti-CD3 (aCD3) nanoarrays fabricated by self-assembled nanopatterning combined with site-directed protein immobilization techniques represent a novel T cell stimulatory platform that allows tight control over ligand orientation and surface density. Here, we show that activation of primary human CD4...
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| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
October 10, 2013
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| In: |
Nano letters
Year: 2013, Volume: 13, Issue: 11, Pages: 5090-5097 |
| ISSN: | 1530-6992 |
| DOI: | 10.1021/nl4022623 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/nl4022623
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| Author Notes: | Jovana Matic, Janosch Deeg, Alexander Scheffold, Itamar Goldstein, and Joachim P. Spatz |
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| 520 | |a Anti-CD3 (aCD3) nanoarrays fabricated by self-assembled nanopatterning combined with site-directed protein immobilization techniques represent a novel T cell stimulatory platform that allows tight control over ligand orientation and surface density. Here, we show that activation of primary human CD4+ T cells, defined by CD69 upregulation, IL-2 production and cell proliferation, correlates with aCD3 density on nanoarrays. Immobilization of aCD3 through nanopatterning had two effects: cell activation was significantly higher on these surfaces than on aCD3-coated plastics and allowed unprecedented fine-tuning of T cell response. | ||
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