Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma
Vascular endothelial growth factor (VEGF) that is secreted by tumor cells plays a key role in angiogenesis. Matrix metalloproteinase 9 (MMP-9) is produced by inflammatory cells, such as stromal granulocytes (PMN), remodels the extracellular matrix and is known to promote angiogenesis indirectly by i...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 March 2011
|
| In: |
Angiogenesis
Year: 2011, Jahrgang: 14, Heft: 3, Pages: 235-243 |
| ISSN: | 1573-7209 |
| DOI: | 10.1007/s10456-011-9207-3 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s10456-011-9207-3
|
| Verfasserangaben: | Dirk Bausch, Thomas Pausch, Tobias Krauss, Ulrich Theodor Hopt, Carlos Fernandez-del-Castillo, Andrew L. Warshaw, Sarah P. Thayer, Tobias Keck |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1761404024 | ||
| 003 | DE-627 | ||
| 005 | 20220820005423.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210628s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10456-011-9207-3 |2 doi | |
| 035 | |a (DE-627)1761404024 | ||
| 035 | |a (DE-599)KXP1761404024 | ||
| 035 | |a (OCoLC)1341417504 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bausch, Dirk |d 1975- |e VerfasserIn |0 (DE-588)128821426 |0 (DE-627)381571297 |0 (DE-576)297349473 |4 aut | |
| 245 | 1 | 0 | |a Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma |c Dirk Bausch, Thomas Pausch, Tobias Krauss, Ulrich Theodor Hopt, Carlos Fernandez-del-Castillo, Andrew L. Warshaw, Sarah P. Thayer, Tobias Keck |
| 264 | 1 | |c 26 March 2011 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 18.06.2021 | ||
| 520 | |a Vascular endothelial growth factor (VEGF) that is secreted by tumor cells plays a key role in angiogenesis. Matrix metalloproteinase 9 (MMP-9) is produced by inflammatory cells, such as stromal granulocytes (PMN), remodels the extracellular matrix and is known to promote angiogenesis indirectly by interacting with VEGF. The aim of this study was to determine the role of PMN-derived MMP-9, its interaction with VEGF, and the efficacy of anti-angiogenic therapy targeting MMP-9 with oral Doxycycline and VEGF with Bevacizumab in pancreatic cancer (PDAC). | ||
| 700 | 1 | |a Pausch, Thomas |d 1982- |e VerfasserIn |0 (DE-588)1115219197 |0 (DE-627)869542311 |0 (DE-576)477679536 |4 aut | |
| 700 | 1 | |a Krauß, Tobias |d 1977- |e VerfasserIn |0 (DE-588)131579614 |0 (DE-627)510993907 |0 (DE-576)253201071 |4 aut | |
| 700 | 1 | |a Hopt, Ulrich T. |d 1948- |e VerfasserIn |0 (DE-588)114006040 |0 (DE-627)491694032 |0 (DE-576)289782406 |4 aut | |
| 700 | 1 | |a Fernandez-del-Castillo, Carlos |e VerfasserIn |4 aut | |
| 700 | 1 | |a Warshaw, Andrew L. |d 1939- |e VerfasserIn |0 (DE-588)1156566622 |0 (DE-627)1019365838 |0 (DE-576)502259930 |4 aut | |
| 700 | 1 | |a Thayer, Sarah P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Keck, Tobias |d 1971- |e VerfasserIn |0 (DE-588)118024582 |0 (DE-627)079197655 |0 (DE-576)178496472 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Angiogenesis |d Dordrecht [u.a.] : Springer Science + Business Media B.V, 1997 |g 14(2011), 3, Seite 235-243 |h Online-Ressource |w (DE-627)320427889 |w (DE-600)2003393-X |w (DE-576)121190838 |x 1573-7209 |7 nnas |a Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma |
| 773 | 1 | 8 | |g volume:14 |g year:2011 |g number:3 |g pages:235-243 |g extent:9 |a Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10456-011-9207-3 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210628 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 1115219197 |a Pausch, Thomas |m 1115219197:Pausch, Thomas |d 910000 |d 910200 |e 910000PP1115219197 |e 910200PP1115219197 |k 0/910000/ |k 1/910000/910200/ |p 2 | ||
| 999 | |a KXP-PPN1761404024 |e 3941758500 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Bausch","display":"Bausch, Dirk","given":"Dirk","role":"aut"},{"role":"aut","given":"Thomas","display":"Pausch, Thomas","family":"Pausch"},{"given":"Tobias","display":"Krauß, Tobias","family":"Krauß","role":"aut"},{"display":"Hopt, Ulrich T.","given":"Ulrich T.","family":"Hopt","role":"aut"},{"family":"Fernandez-del-Castillo","given":"Carlos","display":"Fernandez-del-Castillo, Carlos","role":"aut"},{"role":"aut","family":"Warshaw","given":"Andrew L.","display":"Warshaw, Andrew L."},{"role":"aut","family":"Thayer","given":"Sarah P.","display":"Thayer, Sarah P."},{"role":"aut","given":"Tobias","display":"Keck, Tobias","family":"Keck"}],"recId":"1761404024","name":{"displayForm":["Dirk Bausch, Thomas Pausch, Tobias Krauss, Ulrich Theodor Hopt, Carlos Fernandez-del-Castillo, Andrew L. Warshaw, Sarah P. Thayer, Tobias Keck"]},"origin":[{"dateIssuedDisp":"26 March 2011","dateIssuedKey":"2011"}],"language":["eng"],"title":[{"title_sort":"Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma","title":"Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma"}],"physDesc":[{"extent":"9 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.1007/s10456-011-9207-3"],"eki":["1761404024"]},"relHost":[{"title":[{"title_sort":"Angiogenesis","title":"Angiogenesis"}],"origin":[{"dateIssuedKey":"1997","publisherPlace":"Dordrecht [u.a.] ; Dordrecht [u.a.]","publisher":"Springer Science + Business Media B.V ; Kluwer","dateIssuedDisp":"1997-"}],"note":["Gesehen am 09.03.05"],"part":{"extent":"9","issue":"3","volume":"14","text":"14(2011), 3, Seite 235-243","year":"2011","pages":"235-243"},"id":{"zdb":["2003393-X"],"issn":["1573-7209"],"eki":["320427889"]},"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"recId":"320427889","disp":"Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinomaAngiogenesis","type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.1997/98 -"]}],"note":["Gesehen am 18.06.2021"]} | ||
| SRT | |a BAUSCHDIRKNEUTROPHIL2620 | ||