α-lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria
In the present cross-sectional study, the influence of α-lipoic acid on markers of oxidative stress, assessed by measurement of plasma lipid hydroperoxides (ROOHs), and on the balance between oxidative stress and antioxidant defence, determined by the ratio ROOH/(α-tocopherol/cholesterol), was exami...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 July 1999
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| In: |
Free radical biology and medicine
Year: 1999, Jahrgang: 26, Heft: 11, Pages: 1495-1500 |
| ISSN: | 1873-4596 |
| DOI: | 10.1016/S0891-5849(99)00011-8 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0891-5849(99)00011-8 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0891584999000118 
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| Verfasserangaben: | Valentin Borcea, Jaffar Nourooz-Zadeh, Simon P. Wolff, Martina Klevesath, Marion Hofmann, Heinz Urich, Peter Wahl, Reinhard Ziegler, Hans Tritschler, Barry Halliwell, and Peter P. Nawroth |
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| 245 | 1 | 0 | |a α-lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria |c Valentin Borcea, Jaffar Nourooz-Zadeh, Simon P. Wolff, Martina Klevesath, Marion Hofmann, Heinz Urich, Peter Wahl, Reinhard Ziegler, Hans Tritschler, Barry Halliwell, and Peter P. Nawroth |
| 246 | 3 | 3 | |a Alpha-lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria |
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| 520 | |a In the present cross-sectional study, the influence of α-lipoic acid on markers of oxidative stress, assessed by measurement of plasma lipid hydroperoxides (ROOHs), and on the balance between oxidative stress and antioxidant defence, determined by the ratio ROOH/(α-tocopherol/cholesterol), was examined in 107 patients with diabetes mellitus. Patients receiving α-lipoic acid (600 mg/day for > 3 months) had significant lower ROOHs and a lower ROOH/(α-tocopherol/cholesterol) ratio than those without α-lipoic acid treatment [ROOH: 4.76 ± 2.49 vs. 7.16 ± 3.22 μmol/l; p < .0001] and [ROOH/(α-tocopherol/cholesterol): 1.37 ± 0.72 vs. 2.16 ± 1.17; p < 0.0001]. In addition, the influence of glycemic control and albuminuria on ROOHs and on the ratio of ROOH/(α-tocopherol/cholesterol) was examined in the presence and absence of α-lipoic acid treatment. Patients were subdivided into three groups based on (1) their HbA1 levels (<7.5, 7.5-9.5, and >9.5%) and (2) their urinary albumin concentrations (<20, 20-200, and >200 mg/l). Neither poor glycemic control, nor the presence of micro- or macroalbuminuria prevented the antioxidant effect of α-lipoic acid. Using stepwise multiple regression analysis, α-lipoic acid was found to be the only factor significantly predicting low ROOHs and a low ratio of ROOH/(α-tocopherol/ cholesterol). These data provide evidence that treatment with α-lipoic acid improves significantly the imbalance between increased oxidative stress and depleted antioxidant defence even in patients with poor glycemic control and albuminuria. | ||
| 650 | 4 | |a Diabetes mellitus | |
| 650 | 4 | |a Free radicals | |
| 650 | 4 | |a Lipid peroxidation | |
| 650 | 4 | |a Oxidative stress | |
| 650 | 4 | |a α-Lipoic acid | |
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