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Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: results from the COMPERA registry

Background - Originally reported to occur predominantly in younger women, idiopathic pulmonary arterial hypertension (IPAH) is increasingly diagnosed in elderly patients. We aimed to describe the characteristics of such patients and their survival under clinical practice conditions. - Methods - Pros...

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Hauptverfasser: Höper, Marius (VerfasserIn) , Huscher, Doerte (VerfasserIn) , Ghofrani, H. Ardeschir (VerfasserIn) , Delcroix, Marion (VerfasserIn) , Distler, Oliver (VerfasserIn) , Schweiger, Christian (VerfasserIn) , Grünig, Ekkehard (VerfasserIn) , Stähler, Gerd (VerfasserIn) , Rosenkranz, Stephan (VerfasserIn) , Halank, Michael (VerfasserIn) , Held, Matthias (VerfasserIn) , Grohé, Christian (VerfasserIn) , Lange, Tobias J. (VerfasserIn) , Behr, Juergen (VerfasserIn) , Klose, Hans (VerfasserIn) , Wilkens, Heinrike (VerfasserIn) , Filusch, Arthur (VerfasserIn) , Germann, Martin (VerfasserIn) , Ewert, Ralf (VerfasserIn) , Seyfarth, Hans-Jürgen (VerfasserIn) , Olsson, Karen M. (VerfasserIn) , Opitz, Christian F. (VerfasserIn) , Gaine, Sean P. (VerfasserIn) , Vizza, C. Dario (VerfasserIn) , Vonk-Noordegraaf, Anton (VerfasserIn) , Kaemmerer, Harald (VerfasserIn) , Gibbs, J. Simon R. (VerfasserIn) , Pittrow, David (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2013
In: International journal of cardiology
Year: 2013, Jahrgang: 168, Heft: 2, Pages: 871-880
ISSN:1874-1754
DOI:10.1016/j.ijcard.2012.10.026
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijcard.2012.10.026
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167527312014015
Volltext
Verfasserangaben:Marius M. Hoeper, Doerte Huscher, H. Ardeschir Ghofrani, Marion Delcroix, Oliver Distler, Christian Schweiger, Ekkehard Grunig, Gerd Staehler, Stephan Rosenkranz, Michael Halank, Matthias Held, Christian Grohé, Tobias J. Lange, Juergen Behr, Hans Klose, Heinrike Wilkens, Arthur Filusch, Martin Germann, Ralf Ewert, Hans-Juergen Seyfarth, Karen M. Olsson, Christian F. Opitz, Sean P. Gaine, C. Dario Vizza, Anton Vonk-Noordegraaf, Harald Kaemmerer, J. Simon R. Gibbs, David Pittrow

MARC

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520 |a Background - Originally reported to occur predominantly in younger women, idiopathic pulmonary arterial hypertension (IPAH) is increasingly diagnosed in elderly patients. We aimed to describe the characteristics of such patients and their survival under clinical practice conditions. - Methods - Prospective registry in 28 centers in 6 European countries. Demographics, clinical characteristics, hemodynamics, treatment patterns and outcomes of younger (18-65years) and elderly (>65years) patients with newly diagnosed IPAH (incident cases only) were compared. - Results - A total of 587 patients were eligible for analysis. The median (interquartile, [IQR]) age at diagnosis was 71 (16) years. Younger patients (n=209; median age, 54 [16] years) showed a female-to-male ratio of 2.3:1 whereas the gender ratio in elderly patients (n=378; median age, 75 [8] years) was almost even (1.2:1). Combinations of PAH drugs were widely used in both populations, albeit less frequently in older patients. Elderly patients were less likely to reach current treatment targets (6min walking distance>400m, functional class I or II). The survival rates 1, 2, and 3years after the diagnosis of IPAH were lower in elderly patients, even when adjusted for age- and gender-matched survival tables of the general population (p=0.006 by log-rank analysis). - Conclusions - In countries with an aging population, IPAH is now frequently diagnosed in elderly patients. Compared to younger patients, elderly patients present with a balanced gender ratio and different clinical features, respond less well to medical therapy and have a higher age-adjusted mortality. Further characterization of these patients is required. Clinical trials registration: NCT01347216. 
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