Effects of mycophenolate mofetil introduction in liver transplant patients: results from an observational, non-interventional, multicenter study (LOBSTER)
The benefits of calcineurin inhibitor (CNI)-sparing regimens on renal function following liver transplantation (LT) have been demonstrated in clinical studies. This observational study assessed the real-life effects of mycophenolate mofetil (MMF) introduction in LT patients. Four hundred and ninety-...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 February 2013
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| In: |
Clinical transplantation
Year: 2013, Jahrgang: 27, Heft: 3, Pages: 368-378 |
| ISSN: | 1399-0012 |
| DOI: | 10.1111/ctr.12097 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/ctr.12097 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ctr.12097 
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| Verfasserangaben: | Hans J. Schlitt, Sven Jonas, Tom M. Ganten, Gerrit Grannas, Christian Moench, Falk Rauchfuss, Aiman Obed, Giuseppe Tisone, Antonio D. Pinna, Giorgio E. Gerunda and Susanne Beckebaum |
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| 245 | 1 | 0 | |a Effects of mycophenolate mofetil introduction in liver transplant patients |b results from an observational, non-interventional, multicenter study (LOBSTER) |c Hans J. Schlitt, Sven Jonas, Tom M. Ganten, Gerrit Grannas, Christian Moench, Falk Rauchfuss, Aiman Obed, Giuseppe Tisone, Antonio D. Pinna, Giorgio E. Gerunda and Susanne Beckebaum |
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| 520 | |a The benefits of calcineurin inhibitor (CNI)-sparing regimens on renal function following liver transplantation (LT) have been demonstrated in clinical studies. This observational study assessed the real-life effects of mycophenolate mofetil (MMF) introduction in LT patients. Four hundred and ninety-seven patients in whom MMF was introduced according to local standards or clinical considerations were entered. Patients were grouped by time between transplantation and start of MMF (start of study): Group A (n = 263): ≤6 d; Group B (n = 64): >6 d to ≤1 month; Group C (n = 74): >1 month to ≤1 yr; and Group D (n = 96): >1 yr. CNI sparing occurred in all groups, particularly in Groups C and D. Mean MMF doses at 12 months were 1202.7, 1363.5, 1504.7, and 1578.1 mg/d, respectively, in Groups A-D. At introduction of MMF, median glomerular filtration rate was 73.3, 81.7, 62.7, and 53.7 mL/min/1.73 m2 in Groups A-D. At 12 months, this decreased to 66 mL/min/1.73 m2 in Groups A and B, remained stable in Group C, and increased in Group D (64.8 mL/min/1.73 m2). Serious adverse drug reactions were lowest in Group D. In conclusion, MMF with a subsequent decrease in CNI was well tolerated and improved renal function even years after transplantation. A more forceful MMF dosing strategy with greater CNI sparing may further improve renal function. | ||
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