Gastric bypass leads to improvement of diabetic neuropathy independent of glucose normalization: results of a prospective cohort study (DiaSurg 1 study)
Objective: - Surprisingly, 40% to 95% of patients with type 2 diabetes mellitus (T2DM) show early remission of hyperglycemia after obesity surgery. It is unknown to what extent other diabetes-associated comorbidities such as distal peripheral neuropathy (DPN) might be influenced by obesity...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 2013
|
| In: |
Annals of surgery
Year: 2013, Jahrgang: 258, Heft: 5, Pages: 760-766 |
| ISSN: | 1528-1140 |
| DOI: | 10.1097/SLA.0b013e3182a618b2 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/SLA.0b013e3182a618b2 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/annalsofsurgery/Fulltext/2013/11000/Gastric_Bypass_Leads_to_Improvement_of_Diabetic.13.aspx 
|
| Verfasserangaben: | Beat P. Müller-Stich, MD, Lars Fischer, MD, Hannes G. Kenngott, MD, Matthias Gondan, PhD, Jonas Senft, MD, Gabriella Clemens, MD, Felix Nickel, MD, Thomas Fleming, PhD, Peter P. Nawroth, MD, and Markus W. Büchler, MD |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 176198876X | ||
| 003 | DE-627 | ||
| 005 | 20240414193223.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210706s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1097/SLA.0b013e3182a618b2 |2 doi | |
| 035 | |a (DE-627)176198876X | ||
| 035 | |a (DE-599)KXP176198876X | ||
| 035 | |a (OCoLC)1341418023 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Müller, Beat P. |d 1971- |e VerfasserIn |0 (DE-588)14066209X |0 (DE-627)70374819X |0 (DE-576)317992287 |4 aut | |
| 245 | 1 | 0 | |a Gastric bypass leads to improvement of diabetic neuropathy independent of glucose normalization |b results of a prospective cohort study (DiaSurg 1 study) |c Beat P. Müller-Stich, MD, Lars Fischer, MD, Hannes G. Kenngott, MD, Matthias Gondan, PhD, Jonas Senft, MD, Gabriella Clemens, MD, Felix Nickel, MD, Thomas Fleming, PhD, Peter P. Nawroth, MD, and Markus W. Büchler, MD |
| 264 | 1 | |c November 2013 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 06.07.2021 | ||
| 520 | |a Objective: - Surprisingly, 40% to 95% of patients with type 2 diabetes mellitus (T2DM) show early remission of hyperglycemia after obesity surgery. It is unknown to what extent other diabetes-associated comorbidities such as distal peripheral neuropathy (DPN) might be influenced by obesity surgery. This pilot study aimed at providing further evidence for the impact of Roux-en-Y gastric bypass (RYGB) on both glycemic control and DPN in nonseverely obese patients with insulin-dependent T2DM. - Methods: - In the present prospective cohort study, 20 patients with long-standing, insulin-dependent T2DM and a body mass index (BMI) between 25 and 35 kg/m2 underwent laparoscopic RYGB. Body mass index, glycosylated hemoglobin (HbA1c), and DPN [quantified by the Neuropathy Symptom Score (NSS) and the Neuropathy Deficit Score (NDS)] were investigated. - Results: - Six months after surgery, the preoperative BMI of 32.8 ± 2.1 kg/m2 (mean ± standard deviation) dropped to 25.6 ± 2.5 kg/m2 (P < 0.001). Preoperative HbA1c levels decreased from 8.5 ± 1.2% to 7.1 ± 1.2% (P < 0.001), with 15% of patients having a normalized HbA1c level lower than 6.2%. Of 12 patients with documented DPN, the median NSS was 8 (range, 0-10) preoperatively and 0 (range, 0-9) postoperatively (P = 0.004), with 8 patients scoring an NSS of 0. The median NDS was 6 (range, 2-8) preoperatively and 4 (range, 0-8) postoperatively (P = 0.027), with 1 patient scoring an NDS of 0. All patients had an improvement or normalization in either 1 or both scores. - Conclusions: - As expected, BMI and HbA1c levels improved significantly after RYGB. More interestingly, neuropathy scores, such as NSS and NDS, improved significantly early after surgery. Symptomatic neuropathy was completely reversible in 67% of the patients. These findings add further evidence to the fact that RYGB might be a valuable treatment option not only for improving glycemic control but also for reducing diabetes-associated comorbidities, such as DPN. This points to a complex metabolic effect of RYGB that exceeds glucose normalization. However, the results still need to be confirmed in controlled trials. | ||
| 700 | 1 | |a Fischer, Lars |d 1971- |e VerfasserIn |0 (DE-588)122982606 |0 (DE-627)706116674 |0 (DE-576)302554661 |4 aut | |
| 700 | 1 | |a Kenngott, Hannes Götz |d 1979- |e VerfasserIn |0 (DE-588)141469994 |0 (DE-627)62780117X |0 (DE-576)324023065 |4 aut | |
| 700 | 1 | |a Gondan, Matthias |e VerfasserIn |0 (DE-588)103832159X |0 (DE-627)757123074 |0 (DE-576)181338165 |4 aut | |
| 700 | 1 | |a Senft, Jonas |e VerfasserIn |0 (DE-588)1052201148 |0 (DE-627)787984973 |0 (DE-576)40795077X |4 aut | |
| 700 | 1 | |a Clemens, Gabriella |d 1984- |e VerfasserIn |0 (DE-588)1067535519 |0 (DE-627)818870990 |0 (DE-576)426726308 |4 aut | |
| 700 | 1 | |a Nickel, Felix |d 1982- |e VerfasserIn |0 (DE-588)1067980059 |0 (DE-627)819414875 |0 (DE-576)427122619 |4 aut | |
| 700 | 1 | |a Fleming, Thomas |d 1982- |e VerfasserIn |0 (DE-588)1034445294 |0 (DE-627)745607365 |0 (DE-576)382066804 |4 aut | |
| 700 | 1 | |a Nawroth, Peter Paul |d 1954- |e VerfasserIn |0 (DE-588)1020504897 |0 (DE-627)69123941X |0 (DE-576)360517692 |4 aut | |
| 700 | 1 | |a Büchler, Markus W. |d 1955- |e VerfasserIn |0 (DE-588)120893339 |0 (DE-627)080952526 |0 (DE-576)292434146 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of surgery |d [Erscheinungsort nicht ermittelbar] : Lippincott Williams & Wilkins, 1885 |g 258(2013), 5, Seite 760-766 |h Online-Ressource |w (DE-627)313115222 |w (DE-600)2002200-1 |w (DE-576)090881796 |x 1528-1140 |7 nnas |a Gastric bypass leads to improvement of diabetic neuropathy independent of glucose normalization results of a prospective cohort study (DiaSurg 1 study) |
| 773 | 1 | 8 | |g volume:258 |g year:2013 |g number:5 |g pages:760-766 |g extent:7 |a Gastric bypass leads to improvement of diabetic neuropathy independent of glucose normalization results of a prospective cohort study (DiaSurg 1 study) |
| 856 | 4 | 0 | |u https://doi.org/10.1097/SLA.0b013e3182a618b2 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://journals.lww.com/annalsofsurgery/Fulltext/2013/11000/Gastric_Bypass_Leads_to_Improvement_of_Diabetic.13.aspx |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210706 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 120893339 |a Büchler, Markus W. |m 120893339:Büchler, Markus W. |d 910000 |d 910200 |e 910000PB120893339 |e 910200PB120893339 |k 0/910000/ |k 1/910000/910200/ |p 10 |y j | ||
| 998 | |g 1020504897 |a Nawroth, Peter Paul |m 1020504897:Nawroth, Peter Paul |d 910000 |d 910100 |e 910000PN1020504897 |e 910100PN1020504897 |k 0/910000/ |k 1/910000/910100/ |p 9 | ||
| 998 | |g 1034445294 |a Fleming, Thomas |m 1034445294:Fleming, Thomas |d 910000 |d 910100 |e 910000PF1034445294 |e 910100PF1034445294 |k 0/910000/ |k 1/910000/910100/ |p 8 | ||
| 998 | |g 1067980059 |a Nickel, Felix |m 1067980059:Nickel, Felix |d 910000 |d 910200 |e 910000PN1067980059 |e 910200PN1067980059 |k 0/910000/ |k 1/910000/910200/ |p 7 | ||
| 998 | |g 1067535519 |a Clemens, Gabriella |m 1067535519:Clemens, Gabriella |d 50000 |e 50000PC1067535519 |k 0/50000/ |p 6 | ||
| 998 | |g 1052201148 |a Senft, Jonas |m 1052201148:Senft, Jonas |d 50000 |e 50000PS1052201148 |k 0/50000/ |p 5 | ||
| 998 | |g 103832159X |a Gondan, Matthias |m 103832159X:Gondan, Matthias |d 910000 |d 999701 |e 910000PG103832159X |e 999701PG103832159X |k 0/910000/ |k 1/910000/999701/ |p 4 | ||
| 998 | |g 141469994 |a Kenngott, Hannes Götz |m 141469994:Kenngott, Hannes Götz |d 910000 |d 910200 |e 910000PK141469994 |e 910200PK141469994 |k 0/910000/ |k 1/910000/910200/ |p 3 | ||
| 998 | |g 122982606 |a Fischer, Lars |m 122982606:Fischer, Lars |d 910000 |d 910200 |d 50000 |e 910000PF122982606 |e 910200PF122982606 |e 50000PF122982606 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 2 | ||
| 998 | |g 14066209X |a Müller, Beat P. |m 14066209X:Müller, Beat P. |d 910000 |d 910200 |e 910000PM14066209X |e 910200PM14066209X |k 0/910000/ |k 1/910000/910200/ |p 1 |x j | ||
| 999 | |a KXP-PPN176198876X |e 3945770319 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"176198876X","name":{"displayForm":["Beat P. Müller-Stich, MD, Lars Fischer, MD, Hannes G. Kenngott, MD, Matthias Gondan, PhD, Jonas Senft, MD, Gabriella Clemens, MD, Felix Nickel, MD, Thomas Fleming, PhD, Peter P. Nawroth, MD, and Markus W. Büchler, MD"]},"origin":[{"dateIssuedDisp":"November 2013","dateIssuedKey":"2013"}],"person":[{"family":"Müller","display":"Müller, Beat P.","given":"Beat P.","role":"aut"},{"family":"Fischer","display":"Fischer, Lars","given":"Lars","role":"aut"},{"role":"aut","family":"Kenngott","given":"Hannes Götz","display":"Kenngott, Hannes Götz"},{"given":"Matthias","display":"Gondan, Matthias","family":"Gondan","role":"aut"},{"given":"Jonas","display":"Senft, Jonas","family":"Senft","role":"aut"},{"role":"aut","family":"Clemens","display":"Clemens, Gabriella","given":"Gabriella"},{"display":"Nickel, Felix","given":"Felix","family":"Nickel","role":"aut"},{"role":"aut","display":"Fleming, Thomas","given":"Thomas","family":"Fleming"},{"role":"aut","family":"Nawroth","given":"Peter Paul","display":"Nawroth, Peter Paul"},{"role":"aut","given":"Markus W.","display":"Büchler, Markus W.","family":"Büchler"}],"language":["eng"],"title":[{"subtitle":"results of a prospective cohort study (DiaSurg 1 study)","title_sort":"Gastric bypass leads to improvement of diabetic neuropathy independent of glucose normalization","title":"Gastric bypass leads to improvement of diabetic neuropathy independent of glucose normalization"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.1097/SLA.0b013e3182a618b2"],"eki":["176198876X"]},"physDesc":[{"extent":"7 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["313115222"],"zdb":["2002200-1"],"issn":["1528-1140"]},"part":{"issue":"5","extent":"7","volume":"258","text":"258(2013), 5, Seite 760-766","pages":"760-766","year":"2013"},"note":["Gesehen am 26.09.18"],"origin":[{"dateIssuedDisp":"1885-","publisher":"Lippincott Williams & Wilkins ; Ovid","publisherPlace":"[Erscheinungsort nicht ermittelbar] ; [Erscheinungsort nicht ermittelbar]","dateIssuedKey":"1885"}],"title":[{"title_sort":"Annals of surgery","subtitle":"a monthly review of surgical science and practice","title":"Annals of surgery"}],"pubHistory":["1.1885 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"313115222","disp":"Gastric bypass leads to improvement of diabetic neuropathy independent of glucose normalization results of a prospective cohort study (DiaSurg 1 study)Annals of surgery","language":["eng"]}],"note":["Gesehen am 06.07.2021"]} | ||
| SRT | |a MUELLERBEAGASTRICBYP2013 | ||