Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma
Dendritic cell (DC) vaccination has proven to be an effective and safe adjuvant for cancer immunotherapies. As the presence of DCs within the tumor microenvironment promotes adaptive antitumor immunity, enhancement of DC migration toward the tumor microenvironment following DC vaccination might repr...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 May 2021
|
| In: |
OncoImmunology
Year: 2021, Jahrgang: 10, Pages: 1-14 |
| ISSN: | 2162-402X |
| DOI: | 10.1080/2162402X.2021.1920739 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/2162402X.2021.1920739
|
| Verfasserangaben: | Xin-Wen Zhang, Katrin Huck, Kristine Jähne, Frederik Cichon, Jana K. Sonner, Friederike Ufer, Simone Bauer, Marcel Seungsu Woo, Ed Green, Kevin Lu, Michael Kilian, Manuel A. Friese, Michael Platten and Katharina Sahm |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 176247879X | ||
| 003 | DE-627 | ||
| 005 | 20221025084201.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210708s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/2162402X.2021.1920739 |2 doi | |
| 035 | |a (DE-627)176247879X | ||
| 035 | |a (DE-599)KXP176247879X | ||
| 035 | |a (OCoLC)1341418035 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Zhang, Xin-Wen |d 1995- |e VerfasserIn |0 (DE-588)1236696883 |0 (DE-627)1762469553 |4 aut | |
| 245 | 1 | 0 | |a Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma |c Xin-Wen Zhang, Katrin Huck, Kristine Jähne, Frederik Cichon, Jana K. Sonner, Friederike Ufer, Simone Bauer, Marcel Seungsu Woo, Ed Green, Kevin Lu, Michael Kilian, Manuel A. Friese, Michael Platten and Katharina Sahm |
| 264 | 1 | |c 14 May 2021 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.07.2021 | ||
| 520 | |a Dendritic cell (DC) vaccination has proven to be an effective and safe adjuvant for cancer immunotherapies. As the presence of DCs within the tumor microenvironment promotes adaptive antitumor immunity, enhancement of DC migration toward the tumor microenvironment following DC vaccination might represent one possible approach to increase its therapeutic efficacy. While recent findings suggest the activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) as critical regulator of DC migration in the context of autoimmune diseases, we aimed to investigate the impact of Arc/Arg3.1 expression for DC-based cancer vaccines.To this end, DC migration capacity as well as the induction of T cell-mediated antitumor immunity was assessed in an experimental B16 melanoma model with Arc/Arg3.1−/- and Arc/Arg3.1-expressing BMDCs applied as a subcutaneous vaccine.While antigen presentation on DCs was critical for unleashing effective T cell mediated antitumor immune responses, Arc/Arg3.1 expression enhanced DC migration toward the tumor and secondary lymphoid organs. Moreover, Arc/Arg3.1-expressing BMDCs shape the tumor immune microenvironment by facilitating tumor recruitment of antigen-specific effector T cells.Thus, Arc/Arg3.1 may represent a novel therapeutic target in DCs in order to increase the therapeutic efficacy of DC vaccination. | ||
| 650 | 4 | |a Adoptive immunotherapy | |
| 650 | 4 | |a CD8-positive T-lymphocytes | |
| 650 | 4 | |a dendritic cells | |
| 650 | 4 | |a melanoma | |
| 650 | 4 | |a tumor microenvironment | |
| 700 | 1 | |a Huck, Katrin |d 1987- |e VerfasserIn |0 (DE-588)1162551488 |0 (DE-627)1026684390 |0 (DE-576)50749301X |4 aut | |
| 700 | 1 | |a Jähne, Kristine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cichon, Frederik |d 1983- |e VerfasserIn |0 (DE-588)1220319589 |0 (DE-627)1736693700 |4 aut | |
| 700 | 1 | |a Sonner, Jana K. |e VerfasserIn |0 (DE-588)1082450510 |0 (DE-627)847510700 |0 (DE-576)455440778 |4 aut | |
| 700 | 1 | |a Ufer, Friederike |e VerfasserIn |0 (DE-588)104491310X |0 (DE-627)773113118 |0 (DE-576)398207933 |4 aut | |
| 700 | 1 | |a Bauer, Simone |e VerfasserIn |4 aut | |
| 700 | 1 | |a Woo, Marcel Seungsu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Green, Edward W. |e VerfasserIn |0 (DE-588)1207577499 |0 (DE-627)169408163X |4 aut | |
| 700 | 1 | |a Lu, Kevin Hai-Ning |d 1993- |e VerfasserIn |0 (DE-588)1236699874 |0 (DE-627)176247820X |4 aut | |
| 700 | 1 | |a Kilian, Michael |d 1990- |e VerfasserIn |0 (DE-588)1220319422 |0 (DE-627)1736693255 |4 aut | |
| 700 | 1 | |a Friese, Manuel A. |d 1973- |e VerfasserIn |0 (DE-588)124101151 |0 (DE-627)085638153 |0 (DE-576)294020195 |4 aut | |
| 700 | 1 | |a Platten, Michael |d 1971- |e VerfasserIn |0 (DE-588)121627780 |0 (DE-627)081431848 |0 (DE-576)261969811 |4 aut | |
| 700 | 1 | |a Sahm, Katharina |d 1985- |e VerfasserIn |0 (DE-588)1048541762 |0 (DE-627)780594371 |0 (DE-576)402374452 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t OncoImmunology |d Abingdon : Taylor & Franics, 2012 |g 10(2021), Artikel-ID 1920739, Seite 1-14 |h Online-Ressource |w (DE-627)683365428 |w (DE-600)2645309-5 |w (DE-576)356728366 |x 2162-402X |7 nnas |a Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma |
| 773 | 1 | 8 | |g volume:10 |g year:2021 |g elocationid:1920739 |g pages:1-14 |g extent:14 |a Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma |
| 856 | 4 | 0 | |u https://doi.org/10.1080/2162402X.2021.1920739 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210708 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1048541762 |a Sahm, Katharina |m 1048541762:Sahm, Katharina |d 60000 |d 62700 |e 60000PS1048541762 |e 62700PS1048541762 |k 0/60000/ |k 1/60000/62700/ |p 14 |y j | ||
| 998 | |g 121627780 |a Platten, Michael |m 121627780:Platten, Michael |d 60000 |d 62700 |e 60000PP121627780 |e 62700PP121627780 |k 0/60000/ |k 1/60000/62700/ |p 13 | ||
| 998 | |g 1220319422 |a Kilian, Michael |m 1220319422:Kilian, Michael |d 60000 |d 62700 |e 60000PK1220319422 |e 62700PK1220319422 |k 0/60000/ |k 1/60000/62700/ |p 11 | ||
| 998 | |g 1236699874 |a Lu, Kevin Hai-Ning |m 1236699874:Lu, Kevin Hai-Ning |d 60000 |e 60000PL1236699874 |k 0/60000/ |p 10 | ||
| 998 | |g 1207577499 |a Green, Edward W. |m 1207577499:Green, Edward W. |d 60000 |d 62700 |e 60000PG1207577499 |e 62700PG1207577499 |k 0/60000/ |k 1/60000/62700/ |p 9 | ||
| 998 | |g 1220319589 |a Cichon, Frederik |m 1220319589:Cichon, Frederik |d 140000 |e 140000PC1220319589 |k 0/140000/ |p 4 | ||
| 998 | |g 1162551488 |a Huck, Katrin |m 1162551488:Huck, Katrin |d 60000 |d 62700 |e 60000PH1162551488 |e 62700PH1162551488 |k 0/60000/ |k 1/60000/62700/ |p 2 | ||
| 998 | |g 1236696883 |a Zhang, Xin-Wen |m 1236696883:Zhang, Xin-Wen |d 910000 |d 910100 |e 910000PZ1236696883 |e 910100PZ1236696883 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN176247879X |e 3946537510 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Xin-Wen Zhang, Katrin Huck, Kristine Jähne, Frederik Cichon, Jana K. Sonner, Friederike Ufer, Simone Bauer, Marcel Seungsu Woo, Ed Green, Kevin Lu, Michael Kilian, Manuel A. Friese, Michael Platten and Katharina Sahm"]},"id":{"doi":["10.1080/2162402X.2021.1920739"],"eki":["176247879X"]},"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"14 May 2021"}],"person":[{"display":"Zhang, Xin-Wen","family":"Zhang","given":"Xin-Wen","role":"aut"},{"given":"Katrin","role":"aut","family":"Huck","display":"Huck, Katrin"},{"given":"Kristine","role":"aut","family":"Jähne","display":"Jähne, Kristine"},{"display":"Cichon, Frederik","family":"Cichon","given":"Frederik","role":"aut"},{"family":"Sonner","given":"Jana K.","role":"aut","display":"Sonner, Jana K."},{"display":"Ufer, Friederike","given":"Friederike","role":"aut","family":"Ufer"},{"given":"Simone","role":"aut","family":"Bauer","display":"Bauer, Simone"},{"display":"Woo, Marcel Seungsu","role":"aut","given":"Marcel Seungsu","family":"Woo"},{"display":"Green, Edward W.","given":"Edward W.","role":"aut","family":"Green"},{"role":"aut","given":"Kevin Hai-Ning","family":"Lu","display":"Lu, Kevin Hai-Ning"},{"display":"Kilian, Michael","given":"Michael","role":"aut","family":"Kilian"},{"given":"Manuel A.","role":"aut","family":"Friese","display":"Friese, Manuel A."},{"display":"Platten, Michael","family":"Platten","given":"Michael","role":"aut"},{"display":"Sahm, Katharina","family":"Sahm","role":"aut","given":"Katharina"}],"relHost":[{"part":{"year":"2021","pages":"1-14","extent":"14","volume":"10","text":"10(2021), Artikel-ID 1920739, Seite 1-14"},"id":{"issn":["2162-402X"],"eki":["683365428"],"zdb":["2645309-5"]},"titleAlt":[{"title":"Onco Immunology"}],"pubHistory":["1.2012 -"],"note":["Gesehen am 13.12.2022"],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title":"OncoImmunology","title_sort":"OncoImmunology"}],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"2012-","publisherPlace":"Abingdon ; Austin, Tex.","publisher":"Taylor & Franics ; Landes Bioscience"}],"disp":"Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanomaOncoImmunology","physDesc":[{"extent":"Online-Ressource"}],"recId":"683365428"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 08.07.2021"],"title":[{"title_sort":"Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma","title":"Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma"}],"physDesc":[{"extent":"14 S."}],"recId":"176247879X"} | ||
| SRT | |a ZHANGXINWEACTIVITYRE1420 | ||