Cover Image

Chromogranin A levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis

Chromogranin A (CgA) is a protein found in large dense-core vesicles of neuroendocrine cells and neurons and regulating secretion. A relevance to amyotrophic lateral sclerosis (ALS) was suggested as its overexpression accelerates disease onset in model systems and it interacts with mutant forms of S...

Full description

Saved in:
Bibliographic Details
Main Authors: Verde, Federico (Author) , Steinacker, Petra (Author) , Oeckl, Patrick (Author) , Weishaupt, Jochen H. (Author) , Rosenbohm, Angela (Author) , Silani, Vincenzo (Author) , Ludolph, Albert C. (Author) , Otto, Markus (Author)
Format: Article (Journal)
Language:English
Published: 27 February 2018
In: Neurobiology of aging
Year: 2018, Volume: 67, Pages: 21-22
ISSN:1558-1497
DOI:10.1016/j.neurobiolaging.2018.02.017
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neurobiolaging.2018.02.017
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0197458018300617
Get full text
Author Notes:Federico Verde, Petra Steinacker, Patrick Oeckl, Jochen H. Weishaupt, Angela Rosenbohm, Vincenzo Silani, Albert C. Ludolph, Markus Otto

MARC

LEADER 00000caa a2200000 c 4500
001 1762528487
003 DE-627
005 20240414193226.0
007 cr uuu---uuuuu
008 210708s2018 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.neurobiolaging.2018.02.017  |2 doi 
035 |a (DE-627)1762528487 
035 |a (DE-599)KXP1762528487 
035 |a (OCoLC)1341417917 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Verde, Federico  |e VerfasserIn  |0 (DE-588)1235560007  |0 (DE-627)1760588644  |4 aut 
245 1 0 |a Chromogranin A levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis  |c Federico Verde, Petra Steinacker, Patrick Oeckl, Jochen H. Weishaupt, Angela Rosenbohm, Vincenzo Silani, Albert C. Ludolph, Markus Otto 
264 1 |c 27 February 2018 
300 |a 2 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 08.07.2021 
520 |a Chromogranin A (CgA) is a protein found in large dense-core vesicles of neuroendocrine cells and neurons and regulating secretion. A relevance to amyotrophic lateral sclerosis (ALS) was suggested as its overexpression accelerates disease onset in model systems and it interacts with mutant forms of SOD1. Recently, increased cerebrospinal fluid (CSF) CgA levels have been reported in ALS patients relative to controls. With the aim of confirming this finding, we measured CgA and phosphorylated neurofilament heavy chain (pNFH), an established ALS biomarker, in the CSF of 32 ALS patients and 32 disease controls. ALS patients had clearly increased pNFH levels (p < 0.0001), while CgA levels were only modestly lower relative to controls (p = 0.0265), with wide value overlap and consequently poor discriminative performance. CgA did not correlate with any disease parameters among ALS patients. Our findings suggest that CgA is not a promising clinical biomarker for ALS. 
650 4 |a Amyotrophic lateral sclerosis (ALS) 
650 4 |a Cerebrospinal fluid (CSF) 
650 4 |a Chromogranin A (CgA) 
650 4 |a Phosphorylated neurofilament heavy chain (pNFH) 
700 1 |a Steinacker, Petra  |d 1969-  |e VerfasserIn  |0 (DE-588)120391597  |0 (DE-627)080645550  |0 (DE-576)345718321  |4 aut 
700 1 |a Oeckl, Patrick  |d 1979-  |e VerfasserIn  |0 (DE-588)104125945X  |0 (DE-627)766717488  |0 (DE-576)392358506  |4 aut 
700 1 |a Weishaupt, Jochen H.  |d 1971-  |e VerfasserIn  |0 (DE-588)122148924  |0 (DE-627)705789039  |0 (DE-576)293117810  |4 aut 
700 1 |a Rosenbohm, Angela  |d 1971-  |e VerfasserIn  |0 (DE-588)1213530156  |0 (DE-627)172425619X  |4 aut 
700 1 |a Silani, Vincenzo  |e VerfasserIn  |4 aut 
700 1 |a Ludolph, Albert C.  |d 1953-  |e VerfasserIn  |0 (DE-588)1081317531  |0 (DE-627)845970100  |0 (DE-576)454116195  |4 aut 
700 1 |a Otto, Markus  |e VerfasserIn  |0 (DE-588)1236714962  |0 (DE-627)1762502267  |4 aut 
773 0 8 |i Enthalten in  |t Neurobiology of aging  |d Amsterdam [u.a.] : Elsevier Science, 1980  |g 67(2018), Seite 21-22  |h Online-Ressource  |w (DE-627)306588552  |w (DE-600)1498414-3  |w (DE-576)081953062  |x 1558-1497  |7 nnas  |a Chromogranin A levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis 
773 1 8 |g volume:67  |g year:2018  |g pages:21-22  |g extent:2  |a Chromogranin A levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis 
856 4 0 |u https://doi.org/10.1016/j.neurobiolaging.2018.02.017  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0197458018300617  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20210708 
993 |a Article 
994 |a 2018 
998 |g 122148924  |a Weishaupt, Jochen H.  |m 122148924:Weishaupt, Jochen H.  |p 4 
999 |a KXP-PPN1762528487  |e 3946662927 
BIB |a Y 
SER |a journal 
JSO |a {"name":{"displayForm":["Federico Verde, Petra Steinacker, Patrick Oeckl, Jochen H. Weishaupt, Angela Rosenbohm, Vincenzo Silani, Albert C. Ludolph, Markus Otto"]},"id":{"doi":["10.1016/j.neurobiolaging.2018.02.017"],"eki":["1762528487"]},"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"27 February 2018"}],"relHost":[{"part":{"text":"67(2018), Seite 21-22","volume":"67","extent":"2","year":"2018","pages":"21-22"},"pubHistory":["1.1980 -"],"language":["eng"],"recId":"306588552","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 14.02.20","Ungezählte Beil.: Supplement"],"disp":"Chromogranin A levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosisNeurobiology of aging","title":[{"title_sort":"Neurobiology of aging","title":"Neurobiology of aging"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1558-1497"],"eki":["306588552"],"zdb":["1498414-3"]},"origin":[{"dateIssuedDisp":"1980-","dateIssuedKey":"1980","publisher":"Elsevier Science","publisherPlace":"Amsterdam [u.a.]"}]}],"physDesc":[{"extent":"2 S."}],"person":[{"display":"Verde, Federico","roleDisplay":"VerfasserIn","role":"aut","family":"Verde","given":"Federico"},{"family":"Steinacker","given":"Petra","display":"Steinacker, Petra","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Oeckl, Patrick","role":"aut","family":"Oeckl","given":"Patrick"},{"family":"Weishaupt","given":"Jochen H.","roleDisplay":"VerfasserIn","display":"Weishaupt, Jochen H.","role":"aut"},{"display":"Rosenbohm, Angela","roleDisplay":"VerfasserIn","role":"aut","family":"Rosenbohm","given":"Angela"},{"family":"Silani","given":"Vincenzo","roleDisplay":"VerfasserIn","display":"Silani, Vincenzo","role":"aut"},{"family":"Ludolph","given":"Albert C.","roleDisplay":"VerfasserIn","display":"Ludolph, Albert C.","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Otto, Markus","given":"Markus","family":"Otto"}],"title":[{"title_sort":"Chromogranin A levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis","title":"Chromogranin A levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis"}],"recId":"1762528487","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 08.07.2021"]} 
SRT |a VERDEFEDERCHROMOGRAN2720 

Similar Items