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Characterization of PD-1 and PD-L1 expression in papillary renal cell carcinoma: results of a large multicenter study

Background - Programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) play a decisive role as prognostic markers in clear-cell renal cell carcinoma (RCC). To date, the role of PD-1/PD-L1 as a prognostic marker in papillary RCC (pRCC) remains scarce. - Patients and Methods - Patients’...

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Main Authors: Erlmeier, Franziska (Author) , Steffens, Sandra (Author) , Stöhr, Christine (Author) , Herrmann, Edwin (Author) , Polifka, Iris (Author) , Agaimy, Abbas (Author) , Trojan, Lutz (Author) , Ströbel, Philipp (Author) , Becker, Frank (Author) , Wülfing, Christian (Author) , Barth, Peter (Author) , Stöckle, Michael (Author) , Staehler, Michael (Author) , Stief, Christian (Author) , Haferkamp, Axel (Author) , Hohenfellner, Markus (Author) , Macher-Göppinger, Stephan (Author) , Wullich, Bernd (Author) , Noldus, Joachim (Author) , Brenner, Walburgis (Author) , Roos, Frederik C. (Author) , Walter, Bernhard (Author) , Otto, Wolfgang (Author) , Burger, Maximilian (Author) , Schrader, Andres Jan (Author) , Hartmann, Arndt (Author) , Ivanyi, Philipp (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Clinical genitourinary cancer
Year: 2021, Volume: 19, Issue: 1, Pages: 53-59
ISSN:1938-0682
DOI:10.1016/j.clgc.2020.07.002
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.clgc.2020.07.002
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S155876732030149X
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Author Notes:Franziska Erlmeier, Sandra Steffens, Christine Stöhr, Edwin Herrmann, Iris Polifka, Abbas Agaimy, Lutz Trojan, Philipp Ströbel, Frank Becker, Christian Wülfing, Peter Barth, Michael Stöckle, Michael Staehler, Christian Stief, Axel Haferkamp, Markus Hohenfellner, Stephan Macher-Göppinger, Bernd Wullich, Joachim Noldus, Walburgis Brenner, Frederik C. Roos, Bernhard Walter, Wolfgang Otto, Maximilian Burger, Andres Jan Schrader, Arndt Hartmann, Philipp Ivanyi, (German Network Of Kidney Cancer)
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Summary:Background - Programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) play a decisive role as prognostic markers in clear-cell renal cell carcinoma (RCC). To date, the role of PD-1/PD-L1 as a prognostic marker in papillary RCC (pRCC) remains scarce. - Patients and Methods - Patients’ sample collection was a joint collaboration of the nationwide PANZAR consortium - a multicenter study. Medical history and tumor specimens were collected from 245 and 129 patients with pRCC types 1 and 2, respectively. Expression of PD-1 and PD-L1 was determined by immunohistochemistry in pRCC and tumor-infiltrating mononuclear cells. - Results - Of 374 pRCC specimens, 204 type 1 and 97 type 2 were evaluable for PD-1 and PD-L1 expression analysis. In total, PD-1 and PD-L1 expression were found in 8 (4.9%) of 162 and 12 (7.2%) of 166 evaluable pRCC type 1 specimens. Comparably, PD-1 and PD-L1 expression were found in 2 (2.4%) of 83 and 5 (6.2%) of 81 evaluable pRCC type 2 specimens. Hardly any clinically relevant associations between PD-1 and PD-L1 positivity and clinicopathologic or clinical courses were observed, neither in pRCC type 1 nor type 2. - Conclusion - The analysis of a large pRCC cohort from a multicenter consortium revealed no impact of PD-1/PD-L1 expression on prognosis in patients with pRCC with predominantly limited disease status, neither for type 1 nor type 2. However, the impact of PD-1 and PD-L1 in more advanced pRCC disease needs further elucidation.
Item Description:Epub: Jul 9, 2020
Gesehen am 13.07.2021
Physical Description:Online Resource
ISSN:1938-0682
DOI:10.1016/j.clgc.2020.07.002

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