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The minimum information about a molecular interaction causal statement (MI2CAST)

A large variety of molecular interactions occurs between biomolecular components in cells. When a molecular interaction results in a regulatory effect, exerted by one component onto a downstream component, a so-called ‘causal interaction’ takes place. Causal interactions constitute the building bloc...

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Main Authors: Touré, Vasundra (Author) , Vercruysse, Steven (Author) , Acencio, Marcio Luis (Author) , Lovering, Ruth C (Author) , Orchard, Sandra (Author) , Bradley, Glyn (Author) , Casals-Casas, Cristina (Author) , Chaouiya, Claudine (Author) , del-Toro, Noemi (Author) , Flobak, Åsmund (Author) , Gaudet, Pascale (Author) , Hermjakob, Henning (Author) , Hoyt, Charles Tapley (Author) , Licata, Luana (Author) , Lægreid, Astrid (Author) , Mungall, Christopher J (Author) , Niknejad, Anne (Author) , Panni, Simona (Author) , Perfetto, Livia (Author) , Porras, Pablo (Author) , Pratt, Dexter (Author) , Sáez Rodríguez, Julio (Author) , Thieffry, Denis (Author) , Thomas, Paul D (Author) , Türei, Dénes (Author) , Kuiper, Martin (Author)
Format: Article (Journal) Editorial
Language:English
Published: 8 July 2020
In: Bioinformatics
Year: 2020, Volume: 36, Issue: 24, Pages: 5712-5718
ISSN:1367-4811
DOI:10.1093/bioinformatics/btaa622
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/bioinformatics/btaa622
Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/bioinformatics/article/36/24/5712/5868560
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Author Notes:Vasundra Touré, Steven Vercruysse, Marcio Luis Acencio, Ruth C. Lovering, Sandra Orchard, Glyn Bradley, Cristina Casals-Casas, Claudine Chaouiya, Noemi del-Toro, Åsmund Flobak, Pascale Gaudet, Henning Hermjakob, Charles Tapley Hoyt, Luana Licata, Astrid Lægreid, Christopher J. Mungall, Anne Niknejad, Simona Panni, Livia Perfetto, Pablo Porras, Dexter Pratt, Julio Saez-Rodriguez, Denis Thieffry, Paul D. Thomas, Dénes Türei and Martin Kuiper

MARC

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520 |a A large variety of molecular interactions occurs between biomolecular components in cells. When a molecular interaction results in a regulatory effect, exerted by one component onto a downstream component, a so-called ‘causal interaction’ takes place. Causal interactions constitute the building blocks in our understanding of larger regulatory networks in cells. These causal interactions and the biological processes they enable (e.g. gene regulation) need to be described with a careful appreciation of the underlying molecular reactions. A proper description of this information enables archiving, sharing and reuse by humans and for automated computational processing. Various representations of causal relationships between biological components are currently used in a variety of resources.Here, we propose a checklist that accommodates current representations, called the Minimum Information about a Molecular Interaction CAusal STatement (MI2CAST). This checklist defines both the required core information, as well as a comprehensive set of other contextual details valuable to the end user and relevant for reusing and reproducing causal molecular interaction information. The MI2CAST checklist can be used as reporting guidelines when annotating and curating causal statements, while fostering uniformity and interoperability of the data across resources.The checklist together with examples is accessible at https://github.com/MI2CAST/MI2CASTSupplementary data are available at Bioinformatics online. 
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