The onset of active disease in systemic lupus erythematosus patients is characterised by excessive regulatory CD4+-T-cell differentiation
OBJECTIVES: An imbalance between CD4+-regulatory T-cells (Tregs) and CD4+-responder T-cells (Tresps) correlates with active disease flares in systemic lupus erythematosus (SLE) patients. Both cell subsets consist of highly proliferating Tregs/Tresps expressing inducible T-cell co-stimulatory molecul...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
09/04/2021
|
| In: |
Clinical and experimental rheumatology
Year: 2021, Jahrgang: 39, Heft: 2, Pages: 279-288 |
| ISSN: | 1593-098X |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://pubmed.ncbi.nlm.nih.gov/32573411/
|
| Verfasserangaben: | M. Schaier, C. Gottschalk, F. Kälble, L. Uhlmann, V. Eckstein, C. Müller-Tidow, S. Meuer, K. Mahnke, H.-M. Lorenz, M. Zeier, A. Steinborn |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1762956756 | ||
| 003 | DE-627 | ||
| 005 | 20230426071037.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210715s2021 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)1762956756 | ||
| 035 | |a (DE-599)KXP1762956756 | ||
| 035 | |a (OCoLC)1341419601 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schaier, Matthias |d 1975- |e VerfasserIn |0 (DE-588)129029009 |0 (DE-627)387780335 |0 (DE-576)297455788 |4 aut | |
| 245 | 1 | 4 | |a The onset of active disease in systemic lupus erythematosus patients is characterised by excessive regulatory CD4+-T-cell differentiation |c M. Schaier, C. Gottschalk, F. Kälble, L. Uhlmann, V. Eckstein, C. Müller-Tidow, S. Meuer, K. Mahnke, H.-M. Lorenz, M. Zeier, A. Steinborn |
| 246 | 3 | 3 | |a The onset of active disease in systemic lupus erythematosus patients is characterised by excessive regulatory CD 4 + -T-cell differentiation |
| 264 | 1 | |c 09/04/2021 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Im Titel ist "+" hochgestellt | ||
| 500 | |a Gesehen am 15.07.2021 | ||
| 520 | |a OBJECTIVES: An imbalance between CD4+-regulatory T-cells (Tregs) and CD4+-responder T-cells (Tresps) correlates with active disease flares in systemic lupus erythematosus (SLE) patients. Both cell subsets consist of highly proliferating Tregs/Tresps expressing inducible T-cell co-stimulatory molecule (ICOS) and less proliferating ICOS--Tregs/Tresps. METHODS: Six-colour-flow-cytometric analysis was used to examine the effect of ICOS+- and ICOS--Treg/Tresp cell differentiation on the composition of the total CD4+-T-helper cell pool with ICOS+- and ICOS--Tregs/Tresps. Functionality of Tregs was examined using suppression assays. RESULTS: In 83 healthy volunteers, the ratio of ICOS+-Tregs/ICOS+-Tresps increased significantly with age, while that of ICOS--Tregs/ICOS--Tresps did not change. In 86 SLE patients (SLEDAI <7), disease activity was associated with an age-independently increased ratio of both ICOS+-Tregs/ICOS+-Tresps and ICOS--Tregs/ICOS--Tresps. In these patients, the functional activity of ICOS+-Tregs, but not of ICOS--Tregs, was preserved. In 13 markedly active disease patients (SLEDAI >7), the percentage of both ICOS+-Tregs and ICOS+-Tresps, was strongly increased within total CD4+-T-helper cells. However, the increased ratio of ICOS+-Tregs/ICOS+-Tresps was not maintained in these patients, due to terminal differentiation and accumulation of naïve cells within total ICOS+-Tregs. Despite increased differentiation of both ICOS--Tregs and ICOS--Tresps, the percentage of ICOS--Tregs increased within CD4+-T-helper cells, while that of ICOS--Tresps decreased, resulting in a significantly increased ratio of ICOS--Tregs/ICOS--Tresps independent of age. CONCLUSIONS: Our data reveal a crucial role of Treg immune senescence for the occurrence of disease flares in SLE patients, with ICOS+-Treg cells being most affected. | ||
| 650 | 4 | |a CD4-Positive T-Lymphocytes | |
| 650 | 4 | |a Cell Differentiation | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Lupus Erythematosus, Systemic | |
| 650 | 4 | |a Lymphocyte Activation | |
| 650 | 4 | |a T-Lymphocyte Subsets | |
| 650 | 4 | |a T-Lymphocytes, Regulatory | |
| 700 | 1 | |a Gottschalk, Claudius |d 1991- |e VerfasserIn |0 (DE-588)1180788478 |0 (DE-627)1067867929 |0 (DE-576)520362772 |4 aut | |
| 700 | 1 | |a Kälble, Florian |d 1988- |e VerfasserIn |0 (DE-588)1046752294 |0 (DE-627)777026864 |0 (DE-576)400099039 |4 aut | |
| 700 | 1 | |a Uhlmann, Lorenz |d 1986- |e VerfasserIn |0 (DE-588)106747627X |0 (DE-627)818782021 |0 (DE-576)426685660 |4 aut | |
| 700 | 1 | |a Eckstein, Volker |d 1957- |e VerfasserIn |0 (DE-588)172851408 |0 (DE-627)697780732 |0 (DE-576)133707059 |4 aut | |
| 700 | 1 | |a Müller-Tidow, Carsten |d 1968- |e VerfasserIn |0 (DE-588)1015101798 |0 (DE-627)705330230 |0 (DE-576)351197893 |4 aut | |
| 700 | 1 | |a Meuer, Stefan |d 1951- |e VerfasserIn |0 (DE-588)1020440198 |0 (DE-627)691221286 |0 (DE-576)360422454 |4 aut | |
| 700 | 1 | |a Mahnke, Karsten |e VerfasserIn |0 (DE-588)1022899147 |0 (DE-627)717328007 |0 (DE-576)366144383 |4 aut | |
| 700 | 1 | |a Lorenz, Hanns-Martin |d 1962- |e VerfasserIn |0 (DE-588)112253865 |0 (DE-627)627277845 |0 (DE-576)167601369 |4 aut | |
| 700 | 1 | |a Zeier, Martin |e VerfasserIn |0 (DE-588)1026480302 |0 (DE-627)726772356 |0 (DE-576)371826438 |4 aut | |
| 700 | 1 | |a Steinborn-Kröhl, Andrea |e VerfasserIn |0 (DE-588)1130893448 |0 (DE-627)885250087 |0 (DE-576)48767491X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical and experimental rheumatology |d Pisa : [Verlag nicht ermittelbar], 1999 |g 39(2021), 2, Seite 279-288 |h Online-Ressource |w (DE-627)363748849 |w (DE-600)2105082-X |w (DE-576)498062171 |x 1593-098X |7 nnas |a The onset of active disease in systemic lupus erythematosus patients is characterised by excessive regulatory CD4+-T-cell differentiation |
| 773 | 1 | 8 | |g volume:39 |g year:2021 |g number:2 |g pages:279-288 |g extent:10 |a The onset of active disease in systemic lupus erythematosus patients is characterised by excessive regulatory CD4+-T-cell differentiation |
| 856 | 4 | 0 | |u https://pubmed.ncbi.nlm.nih.gov/32573411/ |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210715 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1130893448 |a Steinborn-Kröhl, Andrea |m 1130893448:Steinborn-Kröhl, Andrea |d 910000 |d 910400 |e 910000PS1130893448 |e 910400PS1130893448 |k 0/910000/ |k 1/910000/910400/ |p 12 | ||
| 998 | |g 1026480302 |a Zeier, Martin |m 1026480302:Zeier, Martin |d 910000 |d 910100 |d 50000 |e 910000PZ1026480302 |e 910100PZ1026480302 |e 50000PZ1026480302 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 10 | ||
| 998 | |g 112253865 |a Lorenz, Hanns-Martin |m 112253865:Lorenz, Hanns-Martin |d 910000 |d 910100 |e 910000PL112253865 |e 910100PL112253865 |k 0/910000/ |k 1/910000/910100/ |p 9 | ||
| 998 | |g 1022899147 |a Mahnke, Karsten |m 1022899147:Mahnke, Karsten |d 910000 |d 911300 |e 910000PM1022899147 |e 911300PM1022899147 |k 0/910000/ |k 1/910000/911300/ |p 8 | ||
| 998 | |g 1020440198 |a Meuer, Stefan |m 1020440198:Meuer, Stefan |d 910000 |d 911600 |e 910000PM1020440198 |e 911600PM1020440198 |k 0/910000/ |k 1/910000/911600/ |p 7 | ||
| 998 | |g 1015101798 |a Müller-Tidow, Carsten |m 1015101798:Müller-Tidow, Carsten |d 910000 |d 910100 |e 910000PM1015101798 |e 910100PM1015101798 |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 998 | |g 172851408 |a Eckstein, Volker |m 172851408:Eckstein, Volker |d 910000 |d 910100 |e 910000PE172851408 |e 910100PE172851408 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 106747627X |a Uhlmann, Lorenz |m 106747627X:Uhlmann, Lorenz |p 4 | ||
| 998 | |g 1046752294 |a Kälble, Florian |m 1046752294:Kälble, Florian |d 910000 |d 910100 |e 910000PK1046752294 |e 910100PK1046752294 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1180788478 |a Gottschalk, Claudius |m 1180788478:Gottschalk, Claudius |d 50000 |e 50000PG1180788478 |k 0/50000/ |p 2 | ||
| 998 | |g 129029009 |a Schaier, Matthias |m 129029009:Schaier, Matthias |d 50000 |e 50000PS129029009 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1762956756 |e 3952319554 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1762956756","physDesc":[{"extent":"10 S."}],"title":[{"title_sort":"onset of active disease in systemic lupus erythematosus patients is characterised by excessive regulatory CD4+-T-cell differentiation","title":"The onset of active disease in systemic lupus erythematosus patients is characterised by excessive regulatory CD4+-T-cell differentiation"}],"note":["Im Titel ist \"+\" hochgestellt","Gesehen am 15.07.2021"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"relHost":[{"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"zdb":["2105082-X"],"issn":["1593-098X"],"eki":["363748849"]},"part":{"extent":"10","text":"39(2021), 2, Seite 279-288","issue":"2","pages":"279-288","volume":"39","year":"2021"},"title":[{"title_sort":"Clinical and experimental rheumatology","title":"Clinical and experimental rheumatology"}],"origin":[{"dateIssuedKey":"1999","dateIssuedDisp":"1999-","publisherPlace":"Pisa","publisher":"[Verlag nicht ermittelbar]"}],"pubHistory":["Nachgewiesen 17.1999 -"],"disp":"The onset of active disease in systemic lupus erythematosus patients is characterised by excessive regulatory CD4+-T-cell differentiationClinical and experimental rheumatology","physDesc":[{"extent":"Online-Ressource"}],"recId":"363748849"}],"person":[{"family":"Schaier","given":"Matthias","role":"aut","display":"Schaier, Matthias"},{"display":"Gottschalk, Claudius","family":"Gottschalk","given":"Claudius","role":"aut"},{"display":"Kälble, Florian","given":"Florian","role":"aut","family":"Kälble"},{"display":"Uhlmann, Lorenz","given":"Lorenz","role":"aut","family":"Uhlmann"},{"family":"Eckstein","role":"aut","given":"Volker","display":"Eckstein, Volker"},{"display":"Müller-Tidow, Carsten","role":"aut","given":"Carsten","family":"Müller-Tidow"},{"display":"Meuer, Stefan","family":"Meuer","given":"Stefan","role":"aut"},{"given":"Karsten","role":"aut","family":"Mahnke","display":"Mahnke, Karsten"},{"family":"Lorenz","given":"Hanns-Martin","role":"aut","display":"Lorenz, Hanns-Martin"},{"display":"Zeier, Martin","family":"Zeier","role":"aut","given":"Martin"},{"role":"aut","given":"Andrea","family":"Steinborn-Kröhl","display":"Steinborn-Kröhl, Andrea"}],"origin":[{"dateIssuedDisp":"09/04/2021","dateIssuedKey":"2021"}],"id":{"eki":["1762956756"]},"titleAlt":[{"title":"The onset of active disease in systemic lupus erythematosus patients is characterised by excessive regulatory CD 4 + -T-cell differentiation"}],"name":{"displayForm":["M. Schaier, C. Gottschalk, F. Kälble, L. Uhlmann, V. Eckstein, C. Müller-Tidow, S. Meuer, K. Mahnke, H.-M. Lorenz, M. Zeier, A. Steinborn"]}} | ||
| SRT | |a SCHAIERMATONSETOFACT0904 | ||