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Zirconium hydrazinediido complexes derived from cyclic hydrazines and their role in the catalytic synthesis of 1,7-annulated indoles

Reaction of cyclic 1,1′-disubstituted hydrazines with the bis(dimethylamido)zirconium complex [Zr{(NXyl)2Npy} (NMe2)2] (1) in the presence of dmap yielded the hexacoordinate zirconium hydrazinediido complexes [Zr{(NXyl)2Npy}(═NNC9H10)(dmap)2] (2) and [Zr{(NXyl)2Npy}(═NNC12H8)(dmap)2] (3). Hydrazined...

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Hauptverfasser: Scholl, Solveig A. (VerfasserIn) , Wadepohl, Hubert (VerfasserIn) , Gade, Lutz H. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: January 27, 2013
In: Organometallics
Year: 2013, Jahrgang: 32, Heft: 3, Pages: 937-940
ISSN:1520-6041
DOI:10.1021/om301235d
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/om301235d
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Verfasserangaben:Solveig A. Scholl, Hubert Wadepohl, and Lutz H. Gade
Beschreibung
Zusammenfassung:Reaction of cyclic 1,1′-disubstituted hydrazines with the bis(dimethylamido)zirconium complex [Zr{(NXyl)2Npy} (NMe2)2] (1) in the presence of dmap yielded the hexacoordinate zirconium hydrazinediido complexes [Zr{(NXyl)2Npy}(═NNC9H10)(dmap)2] (2) and [Zr{(NXyl)2Npy}(═NNC12H8)(dmap)2] (3). Hydrazinediides are thought to be key intermediates in the zirconium-catalyzed reaction of cyclic 1,1′-disubstituted hydrazines and disubstituted alkynes to yield 1,7-annulated indoles. Their basic structural motif is found in 5-HT3 receptor antagonists such as Cilansetron.
Beschreibung:Gesehen am 15.07.2021
Beschreibung:Online Resource
ISSN:1520-6041
DOI:10.1021/om301235d

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