Breast cancer risk factors and survival by tumor subtype: pooled analyses from the breast cancer association consortium
Background: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype. - Methods: We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with 16,890 deaths (8,554 brea...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 26, 2021
|
| In: |
Cancer epidemiology, biomarkers & prevention
Year: 2021, Volume: 30, Issue: 4, Pages: 623-642 |
| ISSN: | 1538-7755 |
| DOI: | 10.1158/1055-9965.EPI-20-0924 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1055-9965.EPI-20-0924 Verlag, lizenzpflichtig, Volltext: https://cebp.aacrjournals.org/content/30/4/623 
|
| Author Notes: | Anna Morra, Volker Arndt, Hermann Brenner, Federico Canzian, Ute Hamann, Rudolf Kaaks, Andreas Schneeweiss, Jenny Chang-Claude [und viele weitere] |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1763031713 | ||
| 003 | DE-627 | ||
| 005 | 20220820020959.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210716s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1158/1055-9965.EPI-20-0924 |2 doi | |
| 035 | |a (DE-627)1763031713 | ||
| 035 | |a (DE-599)KXP1763031713 | ||
| 035 | |a (OCoLC)1341418346 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Morra, Anna |e VerfasserIn |0 (DE-588)1237128331 |0 (DE-627)1763035298 |4 aut | |
| 245 | 1 | 0 | |a Breast cancer risk factors and survival by tumor subtype |b pooled analyses from the breast cancer association consortium |c Anna Morra, Volker Arndt, Hermann Brenner, Federico Canzian, Ute Hamann, Rudolf Kaaks, Andreas Schneeweiss, Jenny Chang-Claude [und viele weitere] |
| 264 | 1 | |c January 26, 2021 | |
| 300 | |a 21 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 16.07.2021 | ||
| 520 | |a Background: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype. - Methods: We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with 16,890 deaths (8,554 breast cancer specific) over 10 years. Cox regression was used to estimate associations between risk factors and 10-year all-cause mortality and breast cancer-specific mortality overall, by estrogen receptor (ER) status, and by intrinsic-like subtype. - Results: There was no evidence of heterogeneous associations between risk factors and mortality by subtype (Padj > 0.30). The strongest associations were between all-cause mortality and BMI ≥30 versus 18.5-25 kg/m2 [HR (95% confidence interval (CI), 1.19 (1.06-1.34)]; current versus never smoking [1.37 (1.27-1.47)], high versus low physical activity [0.43 (0.21-0.86)], age ≥30 years versus <20 years at first pregnancy [0.79 (0.72-0.86)]; >0-<5 years versus ≥10 years since last full-term birth [1.31 (1.11-1.55)]; ever versus never use of oral contraceptives [0.91 (0.87-0.96)]; ever versus never use of menopausal hormone therapy, including current estrogen-progestin therapy [0.61 (0.54-0.69)]. Similar associations with breast cancer mortality were weaker; for example, 1.11 (1.02-1.21) for current versus never smoking. - Conclusions: We confirm associations between modifiable lifestyle factors and 10-year all-cause mortality. There was no strong evidence that associations differed by ER status or intrinsic-like subtype. - Impact: Given the large dataset and lack of evidence that associations between modifiable risk factors and 10-year mortality differed by subtype, these associations could be cautiously used in prognostication models to inform patient-centered care. | ||
| 700 | 1 | |a Arndt, Volker |e VerfasserIn |0 (DE-588)1037275020 |0 (DE-627)755404696 |0 (DE-576)391287338 |4 aut | |
| 700 | 1 | |a Brenner, Hermann |e VerfasserIn |0 (DE-588)1020516445 |0 (DE-627)691247005 |0 (DE-576)360642136 |4 aut | |
| 700 | 1 | |a Canzian, Federico |e VerfasserIn |0 (DE-588)118890468X |0 (DE-627)1667771264 |4 aut | |
| 700 | 1 | |a Hamann, Ute |e VerfasserIn |0 (DE-588)1074024230 |0 (DE-627)830169970 |0 (DE-576)161285090 |4 aut | |
| 700 | 1 | |a Kaaks, Rudolf |d 1960- |e VerfasserIn |0 (DE-588)172809223 |0 (DE-627)697739562 |0 (DE-576)133665518 |4 aut | |
| 700 | 1 | |a Schneeweiss, Andreas |d 1961- |e VerfasserIn |0 (DE-588)109972554 |0 (DE-627)632849630 |0 (DE-576)327251859 |4 aut | |
| 700 | 1 | |a Chang-Claude, Jenny |e VerfasserIn |0 (DE-588)1049304993 |0 (DE-627)781626188 |0 (DE-576)168344475 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer epidemiology, biomarkers & prevention |d Philadelphia, Pa. : AACR, 1991 |g 30(2021), 4, Seite 623-642 |h Online-Ressource |w (DE-627)325489912 |w (DE-600)2036781-8 |w (DE-576)094752745 |x 1538-7755 |7 nnas |a Breast cancer risk factors and survival by tumor subtype pooled analyses from the breast cancer association consortium |
| 773 | 1 | 8 | |g volume:30 |g year:2021 |g number:4 |g pages:623-642 |g extent:21 |a Breast cancer risk factors and survival by tumor subtype pooled analyses from the breast cancer association consortium |
| 856 | 4 | 0 | |u https://doi.org/10.1158/1055-9965.EPI-20-0924 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://cebp.aacrjournals.org/content/30/4/623 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210716 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1049304993 |a Chang-Claude, Jenny |m 1049304993:Chang-Claude, Jenny |d 50000 |e 50000PC1049304993 |k 0/50000/ |p 134 |y j | ||
| 998 | |g 109972554 |a Schneeweiss, Andreas |m 109972554:Schneeweiss, Andreas |d 910000 |d 910400 |d 50000 |e 910000PS109972554 |e 910400PS109972554 |e 50000PS109972554 |k 0/910000/ |k 1/910000/910400/ |k 0/50000/ |p 102 | ||
| 998 | |g 172809223 |a Kaaks, Rudolf |m 172809223:Kaaks, Rudolf |d 50000 |e 50000PK172809223 |k 0/50000/ |p 62 | ||
| 998 | |g 1074024230 |a Hamann, Ute |m 1074024230:Hamann, Ute |d 140000 |e 140000PH1074024230 |k 0/140000/ |p 49 | ||
| 998 | |g 118890468X |a Canzian, Federico |m 118890468X:Canzian, Federico |d 50000 |e 50000PC118890468X |k 0/50000/ |p 17 | ||
| 998 | |g 1020516445 |a Brenner, Hermann |m 1020516445:Brenner, Hermann |d 850000 |d 851600 |d 50000 |e 850000PB1020516445 |e 851600PB1020516445 |e 50000PB1020516445 |k 0/850000/ |k 1/850000/851600/ |k 0/50000/ |p 16 | ||
| 998 | |g 1037275020 |a Arndt, Volker |m 1037275020:Arndt, Volker |d 50000 |e 50000PA1037275020 |k 0/50000/ |p 7 | ||
| 999 | |a KXP-PPN1763031713 |e 3953575996 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Morra","display":"Morra, Anna","role":"aut","given":"Anna"},{"family":"Arndt","given":"Volker","role":"aut","display":"Arndt, Volker"},{"family":"Brenner","role":"aut","given":"Hermann","display":"Brenner, Hermann"},{"display":"Canzian, Federico","given":"Federico","role":"aut","family":"Canzian"},{"family":"Hamann","role":"aut","given":"Ute","display":"Hamann, Ute"},{"display":"Kaaks, Rudolf","given":"Rudolf","role":"aut","family":"Kaaks"},{"role":"aut","given":"Andreas","display":"Schneeweiss, Andreas","family":"Schneeweiss"},{"role":"aut","given":"Jenny","display":"Chang-Claude, Jenny","family":"Chang-Claude"}],"name":{"displayForm":["Anna Morra, Volker Arndt, Hermann Brenner, Federico Canzian, Ute Hamann, Rudolf Kaaks, Andreas Schneeweiss, Jenny Chang-Claude [und viele weitere]"]},"physDesc":[{"extent":"21 S."}],"id":{"doi":["10.1158/1055-9965.EPI-20-0924"],"eki":["1763031713"]},"note":["Gesehen am 16.07.2021"],"relHost":[{"pubHistory":["1.1991/92 -"],"title":[{"title_sort":"Cancer epidemiology, biomarkers & prevention","title":"Cancer epidemiology, biomarkers & prevention"}],"part":{"extent":"21","pages":"623-642","issue":"4","volume":"30","text":"30(2021), 4, Seite 623-642","year":"2021"},"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Breast cancer risk factors and survival by tumor subtype pooled analyses from the breast cancer association consortiumCancer epidemiology, biomarkers & prevention","id":{"eki":["325489912"],"issn":["1538-7755"],"zdb":["2036781-8"]},"note":["Gesehen am 08.06.2023","Fortsetzung der Druck-Ausgabe"],"recId":"325489912","origin":[{"dateIssuedKey":"1991","publisher":"AACR","dateIssuedDisp":"1991-","publisherPlace":"Philadelphia, Pa."}],"type":{"media":"Online-Ressource","bibl":"periodical"},"name":{"displayForm":["American Association for Cancer Research"]}}],"recId":"1763031713","origin":[{"dateIssuedDisp":"January 26, 2021","dateIssuedKey":"2021"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"subtitle":"pooled analyses from the breast cancer association consortium","title":"Breast cancer risk factors and survival by tumor subtype","title_sort":"Breast cancer risk factors and survival by tumor subtype"}],"language":["eng"]} | ||
| SRT | |a MORRAANNAABREASTCANC2620 | ||