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Protomer alignment modulates specificity of RNA substrate recognition by Ire1

The unfolded protein response (UPR) maintains protein folding homeostasis in the endoplasmic reticulum (ER). In metazoan cells, the Ire1 branch of the UPR initiates two functional outputs—non-conventional mRNA splicing and selective mRNA decay (RIDD). By contrast, Ire1 orthologs from Saccharomyces c...

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Main Authors: Li, Weihan (Author) , Crotty, Kelly (Author) , Garrido Ruiz, Diego (Author) , Voorhies, Mark (Author) , Rivera, Carlos (Author) , Sil, Anita (Author) , Mullins, R Dyche (Author) , Jacobson, Matthew P (Author) , Peschek, Jirka (Author) , Walter, Peter (Author)
Format: Article (Journal)
Language:English
Published: 27 April 2021
In: eLife
Year: 2021, Volume: 10, Pages: 1-20
ISSN:2050-084X
DOI:10.7554/eLife.67425
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.7554/eLife.67425
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Author Notes:Weihan Li, Kelly Crotty, Diego Garrido Ruiz, Mark Voorhies, Carlos Rivera, Anita Sil, R Dyche Mullins, Matthew P Jacobson, Jirka Peschek, Peter Walter

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