Buchumschlag

Inhalationally administered semifluorinated alkanes (SFAs) as drug carriers in an experimental model of acute respiratory distress syndrome

Aerosol therapy in patients suffering from acute respiratory distress syndrome (ARDS) has so far failed in improving patients’ outcomes. This might be because dependent lung areas cannot be reached by conventional aerosols. Due to their physicochemical properties, semifluorinated alkanes (SFAs) coul...

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Bibliographische Detailangaben
Hauptverfasser: Otto, Matthias (VerfasserIn) , Krebs, Jörg (VerfasserIn) , Welker, Peter (VerfasserIn) , Holm, René (VerfasserIn) , Thiel, Manfred (VerfasserIn) , Gattinoni, Luciano (VerfasserIn) , Quintel, Michael (VerfasserIn) , Tsagogiorgas, Charalambos (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 23 March 2021
In: Pharmaceutics
Year: 2021, Jahrgang: 13, Heft: 3, Pages: 1-15
ISSN:1999-4923
DOI:10.3390/pharmaceutics13030431
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/pharmaceutics13030431
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1999-4923/13/3/431
Volltext
Verfasserangaben:Matthias Otto, Jörg Krebs, Peter Welker, René Holm, Manfred Thiel, Luciano Gattinoni, Michael Quintel and Charalambos Tsagogiorgas
Beschreibung
Zusammenfassung:Aerosol therapy in patients suffering from acute respiratory distress syndrome (ARDS) has so far failed in improving patients’ outcomes. This might be because dependent lung areas cannot be reached by conventional aerosols. Due to their physicochemical properties, semifluorinated alkanes (SFAs) could address this problem. After induction of ARDS, 26 pigs were randomized into three groups: (1) control (Sham), (2) perfluorohexyloctane (F6H8), and (3) F6H8-ibuprofen. Using a nebulization catheter, (2) received 1 mL/kg F6H8 while (3) received 1 mL/kg F6H8 with 6 mg/mL ibuprofen. Ibuprofen plasma and lung tissue concentration, bronchoalveolar lavage (BAL) fluid concentration of TNF-α, IL-8, and IL-6, and lung mechanics were measured. The ibuprofen concentration was equally distributed to the dependent parts of the right lungs. Pharmacokinetic data demonstrated systemic absorption of ibuprofen proofing a transport across the alveolo-capillary membrane. A significantly lower TNF-α concentration was observed in (2) and (3) when compared to the control group (1). There were no significant differences in IL-8 and IL-6 concentrations and lung mechanics. F6H8 aerosol seemed to be a suitable carrier for pulmonary drug delivery to dependent ARDS lung regions without having negative effects on lung mechanics.
Beschreibung:Gesehen am 29.07.2021
Beschreibung:Online Resource
ISSN:1999-4923
DOI:10.3390/pharmaceutics13030431

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