Igf signaling couples retina growth with body growth by modulating progenitor cell division

How the body and organs balance their relative growth is of key importance for coordinating size and function. This is of particular relevance in organisms, which continue to grow over their entire life span. We addressed this issue in the neuroretina of medaka fish (Oryzias latipes), a well-studied...

Full description

Saved in:
Bibliographic Details
Main Authors: Becker, Clara (Author) , Lust, Katharina (Author) , Wittbrodt, Joachim (Author)
Format: Article (Journal)
Language:English
Published: 15 April 2021
In: Development
Year: 2021, Volume: 148, Issue: 7, Pages: 1-13
ISSN:1477-9129
DOI:10.1242/dev.199133
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1242/dev.199133
Get full text
Author Notes:Clara Becker, Katharina Lust and Joachim Wittbrodt

MARC

LEADER 00000caa a2200000 c 4500
001 1764914686
003 DE-627
005 20220820025051.0
007 cr uuu---uuuuu
008 210729s2021 xx |||||o 00| ||eng c
024 7 |a 10.1242/dev.199133  |2 doi 
035 |a (DE-627)1764914686 
035 |a (DE-599)KXP1764914686 
035 |a (OCoLC)1341419905 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Becker, Clara  |d 1990-  |e VerfasserIn  |0 (DE-588)1202884857  |0 (DE-627)1687453810  |4 aut 
245 1 0 |a Igf signaling couples retina growth with body growth by modulating progenitor cell division  |c Clara Becker, Katharina Lust and Joachim Wittbrodt 
264 1 |c 15 April 2021 
300 |a 13 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 29.07.2021 
520 |a How the body and organs balance their relative growth is of key importance for coordinating size and function. This is of particular relevance in organisms, which continue to grow over their entire life span. We addressed this issue in the neuroretina of medaka fish (Oryzias latipes), a well-studied system with which to address vertebrate organ growth. We reveal that a central growth regulator, Igf1 receptor (Igf1r), is necessary and sufficient for proliferation control in the postembryonic retinal stem cell niche: the ciliary marginal zone (CMZ). Targeted activation of Igf1r signaling in the CMZ uncouples neuroretina growth from body size control, and we demonstrate that Igf1r operates on progenitor cells, stimulating their proliferation. Activation of Igf1r signaling increases retinal size while preserving its structural integrity, revealing a modular organization in which progenitor differentiation and neurogenesis are self-organized and highly regulated. Our findings position Igf signaling as a key module for controlling retinal size and composition, with important evolutionary implications. 
700 1 |a Lust, Katharina  |e VerfasserIn  |0 (DE-588)1124412263  |0 (DE-627)878087400  |0 (DE-576)482493526  |4 aut 
700 1 |a Wittbrodt, Joachim  |e VerfasserIn  |0 (DE-588)1038250919  |0 (DE-627)756835356  |0 (DE-576)167753401  |4 aut 
773 0 8 |i Enthalten in  |t Development  |d Cambridge : The Company of Biologists, 1987  |g 148(2021), 7, Artikel-ID dev199133, Seite 1-13  |h Online-Ressource  |w (DE-627)31982439X  |w (DE-600)2007916-3  |w (DE-576)090893131  |x 1477-9129  |7 nnas  |a Igf signaling couples retina growth with body growth by modulating progenitor cell division 
773 1 8 |g volume:148  |g year:2021  |g number:7  |g elocationid:dev199133  |g pages:1-13  |g extent:13  |a Igf signaling couples retina growth with body growth by modulating progenitor cell division 
856 4 0 |u https://doi.org/10.1242/dev.199133  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20210729 
993 |a Article 
994 |a 2021 
998 |g 1038250919  |a Wittbrodt, Joachim  |m 1038250919:Wittbrodt, Joachim  |d 700000  |d 721000  |e 700000PW1038250919  |e 721000PW1038250919  |k 0/700000/  |k 1/700000/721000/  |p 3  |y j 
998 |g 1124412263  |a Lust, Katharina  |m 1124412263:Lust, Katharina  |p 2 
998 |g 1202884857  |a Becker, Clara  |m 1202884857:Becker, Clara  |d 140000  |e 140000PB1202884857  |k 0/140000/  |p 1  |x j 
999 |a KXP-PPN1764914686  |e 3958488358 
BIB |a Y 
SER |a journal 
JSO |a {"physDesc":[{"extent":"13 S."}],"language":["eng"],"id":{"doi":["10.1242/dev.199133"],"eki":["1764914686"]},"recId":"1764914686","title":[{"title_sort":"Igf signaling couples retina growth with body growth by modulating progenitor cell division","title":"Igf signaling couples retina growth with body growth by modulating progenitor cell division"}],"person":[{"role":"aut","given":"Clara","roleDisplay":"VerfasserIn","family":"Becker","display":"Becker, Clara"},{"given":"Katharina","role":"aut","family":"Lust","display":"Lust, Katharina","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Wittbrodt, Joachim","family":"Wittbrodt","role":"aut","given":"Joachim"}],"note":["Gesehen am 29.07.2021"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"15 April 2021"}],"relHost":[{"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title":"Development","title_sort":"Development"}],"note":["Gesehen am 26.06.2025"],"titleAlt":[{"title":"Development <Cambridge>"}],"recId":"31982439X","physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"id":{"eki":["31982439X"],"issn":["1477-9129"],"zdb":["2007916-3"]},"corporate":[{"role":"isb","display":"The Company of Biologists","roleDisplay":"Herausgebendes Organ"}],"name":{"displayForm":["Company of Biologists"]},"part":{"issue":"7","extent":"13","text":"148(2021), 7, Artikel-ID dev199133, Seite 1-13","year":"2021","pages":"1-13","volume":"148"},"disp":"Igf signaling couples retina growth with body growth by modulating progenitor cell divisionDevelopment","pubHistory":["Volume 99, 1 (January 1987)-"],"origin":[{"dateIssuedKey":"1987","publisherPlace":"Cambridge","dateIssuedDisp":"1987-","publisher":"The Company of Biologists"}]}],"name":{"displayForm":["Clara Becker, Katharina Lust and Joachim Wittbrodt"]}} 
SRT |a BECKERCLARIGFSIGNALI1520