Cover Image

Prevalence and 30-day mortality in hospitalized patients with Covid-19 and prior lung diseases

Introduction - Patients with pre-existing respiratory diseases in the setting of COVID-19 may have a greater risk of severe complications and even death. - Methods - A retrospective, multicenter, cohort study with 5847 COVID-19 patients admitted to hospitals. Patients were separated in two groups, w...

Full description

Saved in:
Bibliographic Details
Main Authors: Signes-Costa, Jaime (Author) , Núñez-Gil, Iván J. (Author) , Soriano, Joan B. (Author) , Arroyo-Espliguero, Ramón (Author) , Eid, Charbel Maroun (Author) , Romero, Rodolfo (Author) , Uribarri, Aitor (Author) , Fernández-Rozas, Inmaculada (Author) , Aguado, Marcos García (Author) , Becerra-Muñoz, Víctor Manuel (Author) , Huang, Jia (Author) , Pepe, Martino (Author) , Cerrato, Enrico (Author) , Raposeiras, Sergio (Author) , Gonzalez, Adelina (Author) , Franco-Leon, Francisco (Author) , Wang, Lin (Author) , Alfonso, Emilio (Author) , Ugo, Fabrizio (Author) , García-Prieto, Juan Fortunato (Author) , Feltes, Gisela (Author) , Abumayyaleh, Mohammad S. A. (Author) , Espejo-Paeres, Carolina (Author) , Jativa, Jorge (Author) , Masjuan, Alvaro López (Author) , Macaya, Carlos (Author) , Carbonell Asíns, Juan A. (Author) , Estrada, Vicente (Author)
Format: Article (Journal)
Language:English
Published: April 2021
In: Archivos de bronconeumología
Year: 2021, Volume: 57, Issue: 2, Pages: 13-20
ISSN:1579-2129
DOI:10.1016/j.arbres.2020.11.012
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.arbres.2020.11.012
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0300289620305354
Get full text
Author Notes:Jaime Signes-Costa, Iván J. Núñez-Gil, Joan B. Soriano, Ramón Arroyo-Espliguero, Charbel Maroun Eid, Rodolfo Romero, Aitor Uribarri, Inmaculada Fernández-Rozas, Marcos García Aguado, Víctor Manuel Becerra-Muñoz, Jia Huang, Martino Pepe, Enrico Cerrato, Sergio Raposeiras, Adelina Gonzalez, Francisco Franco-Leon, Lin Wang, Emilio Alfonso, Fabrizio Ugo, Juan Fortunato García-Prieto, Gisela Feltes, Mohammad Abumayyaleh, Carolina Espejo-Paeres, Jorge Jativa, Alvaro López Masjuan, Carlos Macaya, Juan A. Carbonell Asíns, Vicente Estrada

MARC

LEADER 00000caa a2200000 c 4500
001 1765319919
003 DE-627
005 20230427153500.0
007 cr uuu---uuuuu
008 210803s2021 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.arbres.2020.11.012  |2 doi 
035 |a (DE-627)1765319919 
035 |a (DE-599)KXP1765319919 
035 |a (OCoLC)1341420295 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Signes-Costa, Jaime  |e VerfasserIn  |0 (DE-588)1238107966  |0 (DE-627)1765320631  |4 aut 
245 1 0 |a Prevalence and 30-day mortality in hospitalized patients with Covid-19 and prior lung diseases  |c Jaime Signes-Costa, Iván J. Núñez-Gil, Joan B. Soriano, Ramón Arroyo-Espliguero, Charbel Maroun Eid, Rodolfo Romero, Aitor Uribarri, Inmaculada Fernández-Rozas, Marcos García Aguado, Víctor Manuel Becerra-Muñoz, Jia Huang, Martino Pepe, Enrico Cerrato, Sergio Raposeiras, Adelina Gonzalez, Francisco Franco-Leon, Lin Wang, Emilio Alfonso, Fabrizio Ugo, Juan Fortunato García-Prieto, Gisela Feltes, Mohammad Abumayyaleh, Carolina Espejo-Paeres, Jorge Jativa, Alvaro López Masjuan, Carlos Macaya, Juan A. Carbonell Asíns, Vicente Estrada 
264 1 |c April 2021 
300 |a 8 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 03.08.2021 
520 |a Introduction - Patients with pre-existing respiratory diseases in the setting of COVID-19 may have a greater risk of severe complications and even death. - Methods - A retrospective, multicenter, cohort study with 5847 COVID-19 patients admitted to hospitals. Patients were separated in two groups, with/without previous lung disease. Evaluation of factors associated with survival and secondary composite end-point such as ICU admission and respiratory support, were explored. - Results - 1,271 patients (22%) had a previous lung disease, mostly COPD. All-cause mortality occurred in 376 patients with lung disease (29.5%) and in 819 patients without (17.9%) (p<0.001). Kaplan-Meier curves showed that patients with lung diseases had a worse 30-day survival (HR=1.78; 95%C.I. 1.58-2.01; p<0.001) and COPD had almost 40% mortality. Multivariable Cox regression showed that prior lung disease remained a risk factor for mortality (HR, 1.21; 95%C.I. 1.02-1.44; p=0.02). Variables independently associated with all-cause mortality risk in patients with lung diseases were oxygen saturation less than 92% on admission (HR, 4.35; 95% CI 3.08-6.15) and elevated D-dimer (HR, 1.84; 95% CI 1.27-2.67). Age younger than 60 years (HR 0.37; 95% CI 0.21-0.65) was associated with decreased risk of death. - Conclusions - Previous lung disease is a risk factor for mortality in patients with COVID-19. Older age, male gender, home oxygen therapy, and respiratory failure on admission were associated with an increased mortality. Efforts must be done to identify respiratory patients to set measures to improve their clinical outcomes. - Resumen - Introducción - Los pacientes con enfermedades respiratorias preexistentes pueden tener en el contexto de la covid-19 un mayor riesgo de complicaciones graves e incluso de muerte. - Métodos - Estudio de cohortes multicéntrico y retrospectivo de 5.847 pacientes con covid-19 ingresados en hospitales. Los pacientes se separaron en 2 grupos, sin y con enfermedad pulmonar previa. Se evaluaron factores asociados con la supervivencia y criterios combinados de valoración secundarios, como el ingreso en la UCI y la necesidad de asistencia respiratoria. - Resultados - Mil doscientos setenta y un (1.271) pacientes (22%) tenían una enfermedad pulmonar previa, principalmente EPOC. La mortalidad por todas las causas ocurrió en 376 pacientes con enfermedad pulmonar (29,5%) y en 819 pacientes sin enfermedad pulmonar (17,9%; p<0,001). Las curvas de Kaplan-Meier mostraron que los pacientes con enfermedades pulmonares tenían una peor supervivencia a los 30 días (HR: 1,78; IC del 95%: 1,58-2,01; p<0,001) y la EPOC tenía una mortalidad de casi el 40%. La regresión de Cox multivariante mostró que la enfermedad pulmonar previa seguía siendo un factor de riesgo de mortalidad (HR: 1,21; IC del 95%: 1,02-1,44; p=0,02). Las variables asociadas de forma independiente con el riesgo de muerte por todas las causas en pacientes con enfermedades pulmonares fueron la saturación de oxígeno inferior al 92% al ingreso (HR: 4,35; IC del 95%: 3,08-6,15) y el dímero D elevado (HR: 1,84; IC del 95%: 1,27-2,67). La edad menor de 60 años (HR: 0,37; IC del 95%: 0,21-0,65) se asoció con una disminución del riesgo de muerte. - Conclusiones - La enfermedad pulmonar previa es un factor de riesgo de muerte en pacientes con covid-19. La edad avanzada, el sexo masculino, la oxigenoterapia domiciliaria y la insuficiencia respiratoria al ingreso se asociaron con un aumento de la mortalidad. Se deben realizar esfuerzos para identificar a los pacientes respiratorios y establecer medidas para mejorar sus resultados clínicos. 
650 4 |a 30-Day mortality 
650 4 |a COPD 
650 4 |a COVID-19 
650 4 |a Enfermedades respiratorias 
650 4 |a EPOC 
650 4 |a Mortalidad a 30 días 
650 4 |a Prognosis 
650 4 |a Pronóstico 
650 4 |a Respiratory diseases 
700 1 |a Núñez-Gil, Iván J.  |e VerfasserIn  |4 aut 
700 1 |a Soriano, Joan B.  |e VerfasserIn  |4 aut 
700 1 |a Arroyo-Espliguero, Ramón  |e VerfasserIn  |4 aut 
700 1 |a Eid, Charbel Maroun  |e VerfasserIn  |4 aut 
700 1 |a Romero, Rodolfo  |e VerfasserIn  |4 aut 
700 1 |a Uribarri, Aitor  |e VerfasserIn  |4 aut 
700 1 |a Fernández-Rozas, Inmaculada  |e VerfasserIn  |4 aut 
700 1 |a Aguado, Marcos García  |e VerfasserIn  |4 aut 
700 1 |a Becerra-Muñoz, Víctor Manuel  |e VerfasserIn  |4 aut 
700 1 |a Huang, Jia  |e VerfasserIn  |4 aut 
700 1 |a Pepe, Martino  |e VerfasserIn  |4 aut 
700 1 |a Cerrato, Enrico  |e VerfasserIn  |4 aut 
700 1 |a Raposeiras, Sergio  |e VerfasserIn  |4 aut 
700 1 |a Gonzalez, Adelina  |e VerfasserIn  |4 aut 
700 1 |a Franco-Leon, Francisco  |e VerfasserIn  |4 aut 
700 1 |a Wang, Lin  |e VerfasserIn  |4 aut 
700 1 |a Alfonso, Emilio  |e VerfasserIn  |4 aut 
700 1 |a Ugo, Fabrizio  |e VerfasserIn  |4 aut 
700 1 |a García-Prieto, Juan Fortunato  |e VerfasserIn  |4 aut 
700 1 |a Feltes, Gisela  |e VerfasserIn  |4 aut 
700 1 |a Abumayyaleh, Mohammad S. A.  |d 1990-  |e VerfasserIn  |0 (DE-588)1215107617  |0 (DE-627)172611743X  |4 aut 
700 1 |a Espejo-Paeres, Carolina  |e VerfasserIn  |4 aut 
700 1 |a Jativa, Jorge  |e VerfasserIn  |4 aut 
700 1 |a Masjuan, Alvaro López  |e VerfasserIn  |4 aut 
700 1 |a Macaya, Carlos  |e VerfasserIn  |4 aut 
700 1 |a Carbonell Asíns, Juan A.  |e VerfasserIn  |4 aut 
700 1 |a Estrada, Vicente  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Archivos de bronconeumología  |d Barcelona [u.a.] : Elsevier Doyma [u.a.], 1964  |g 57(2021), 2, Suppl., Seite 13-20  |h Online-Ressource  |w (DE-627)352109319  |w (DE-600)2084843-2  |w (DE-576)267762143  |x 1579-2129  |7 nnas  |a Prevalence and 30-day mortality in hospitalized patients with Covid-19 and prior lung diseases 
773 1 8 |g volume:57  |g year:2021  |g number:2  |g supplement:Suppl.  |g pages:13-20  |g extent:8  |a Prevalence and 30-day mortality in hospitalized patients with Covid-19 and prior lung diseases 
856 4 0 |u https://doi.org/10.1016/j.arbres.2020.11.012  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0300289620305354  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20210803 
993 |a Article 
994 |a 2021 
998 |g 1215107617  |a Abumayyaleh, Mohammad S. A.  |m 1215107617:Abumayyaleh, Mohammad S. A.  |d 60000  |d 61000  |e 60000PA1215107617  |e 61000PA1215107617  |k 0/60000/  |k 1/60000/61000/  |p 22 
999 |a KXP-PPN1765319919  |e 396033849X 
BIB |a Y 
SER |a journal 
JSO |a {"name":{"displayForm":["Jaime Signes-Costa, Iván J. Núñez-Gil, Joan B. Soriano, Ramón Arroyo-Espliguero, Charbel Maroun Eid, Rodolfo Romero, Aitor Uribarri, Inmaculada Fernández-Rozas, Marcos García Aguado, Víctor Manuel Becerra-Muñoz, Jia Huang, Martino Pepe, Enrico Cerrato, Sergio Raposeiras, Adelina Gonzalez, Francisco Franco-Leon, Lin Wang, Emilio Alfonso, Fabrizio Ugo, Juan Fortunato García-Prieto, Gisela Feltes, Mohammad Abumayyaleh, Carolina Espejo-Paeres, Jorge Jativa, Alvaro López Masjuan, Carlos Macaya, Juan A. Carbonell Asíns, Vicente Estrada"]},"recId":"1765319919","note":["Gesehen am 03.08.2021"],"person":[{"role":"aut","display":"Signes-Costa, Jaime","family":"Signes-Costa","given":"Jaime"},{"family":"Núñez-Gil","display":"Núñez-Gil, Iván J.","given":"Iván J.","role":"aut"},{"role":"aut","given":"Joan B.","display":"Soriano, Joan B.","family":"Soriano"},{"given":"Ramón","family":"Arroyo-Espliguero","display":"Arroyo-Espliguero, Ramón","role":"aut"},{"given":"Charbel Maroun","family":"Eid","display":"Eid, Charbel Maroun","role":"aut"},{"role":"aut","family":"Romero","display":"Romero, Rodolfo","given":"Rodolfo"},{"role":"aut","family":"Uribarri","display":"Uribarri, Aitor","given":"Aitor"},{"family":"Fernández-Rozas","display":"Fernández-Rozas, Inmaculada","given":"Inmaculada","role":"aut"},{"family":"Aguado","display":"Aguado, Marcos García","given":"Marcos García","role":"aut"},{"given":"Víctor Manuel","family":"Becerra-Muñoz","display":"Becerra-Muñoz, Víctor Manuel","role":"aut"},{"role":"aut","family":"Huang","display":"Huang, Jia","given":"Jia"},{"display":"Pepe, Martino","family":"Pepe","given":"Martino","role":"aut"},{"role":"aut","display":"Cerrato, Enrico","family":"Cerrato","given":"Enrico"},{"role":"aut","family":"Raposeiras","display":"Raposeiras, Sergio","given":"Sergio"},{"family":"Gonzalez","display":"Gonzalez, Adelina","given":"Adelina","role":"aut"},{"role":"aut","display":"Franco-Leon, Francisco","family":"Franco-Leon","given":"Francisco"},{"given":"Lin","display":"Wang, Lin","family":"Wang","role":"aut"},{"role":"aut","given":"Emilio","display":"Alfonso, Emilio","family":"Alfonso"},{"display":"Ugo, Fabrizio","family":"Ugo","given":"Fabrizio","role":"aut"},{"given":"Juan Fortunato","family":"García-Prieto","display":"García-Prieto, Juan Fortunato","role":"aut"},{"role":"aut","family":"Feltes","display":"Feltes, Gisela","given":"Gisela"},{"role":"aut","given":"Mohammad S. A.","family":"Abumayyaleh","display":"Abumayyaleh, Mohammad S. A."},{"family":"Espejo-Paeres","display":"Espejo-Paeres, Carolina","given":"Carolina","role":"aut"},{"family":"Jativa","display":"Jativa, Jorge","given":"Jorge","role":"aut"},{"given":"Alvaro López","display":"Masjuan, Alvaro López","family":"Masjuan","role":"aut"},{"role":"aut","given":"Carlos","display":"Macaya, Carlos","family":"Macaya"},{"given":"Juan A.","family":"Carbonell Asíns","display":"Carbonell Asíns, Juan A.","role":"aut"},{"display":"Estrada, Vicente","family":"Estrada","given":"Vicente","role":"aut"}],"title":[{"title":"Prevalence and 30-day mortality in hospitalized patients with Covid-19 and prior lung diseases","title_sort":"Prevalence and 30-day mortality in hospitalized patients with Covid-19 and prior lung diseases"}],"physDesc":[{"extent":"8 S."}],"relHost":[{"part":{"pages":"13-20","text":"57(2021), 2, Suppl., Seite 13-20","volume":"57","issue":"2","year":"2021","extent":"8"},"titleAlt":[{"title":"Archivos de bronconeumología. Spanish version"}],"title":[{"title_sort":"Archivos de bronconeumología","subtitle":"órgano oficial de la Sociedad Española de Neumología y Cirugía Torácica, SEPAR","title":"Archivos de bronconeumología"}],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng","spa"],"id":{"issn":["1579-2129"],"zdb":["2084843-2"],"eki":["352109319"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"dateIssuedDisp":"1964-","publisherPlace":"Barcelona [u.a.] ; Barcelona","publisher":"Elsevier Doyma [u.a.] ; Doyma","dateIssuedKey":"1964"}],"recId":"352109319","pubHistory":["Vol. 1, núm. 1 (enero 1964)-"],"note":["Gesehen am 20.04.2023"],"disp":"Prevalence and 30-day mortality in hospitalized patients with Covid-19 and prior lung diseasesArchivos de bronconeumología"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1765319919"],"doi":["10.1016/j.arbres.2020.11.012"]},"language":["eng"],"origin":[{"dateIssuedDisp":"April 2021","dateIssuedKey":"2021"}]} 
SRT |a SIGNESCOSTPREVALENCE2021 

Similar Items