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Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation

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Hypoxia-induced radioresistance constitutes a major obstacle for a curative treatment of cancer. The aim of this study was to investigate effects of photon and carbon ion irradiation in combination with inhibitors of DNA-Damage Response (DDR) on tumor cell radiosensitivity under hypoxic conditions.

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Main Authors: Klein, Carmen (Author) , Dokić, Ivana (Author) , Mairani, Andrea (Author) , Mein, Stewart (Author) , Brons, Stephan (Author) , Häring, Peter (Author) , Haberer, Thomas (Author) , Jäkel, Oliver (Author) , Zimmermann, Astrid (Author) , Zenke, Frank (Author) , Blaukat, Andree (Author) , Debus, Jürgen (Author) , Abdollahi, Amir (Author)
Format: Article (Journal)
Language:English
Published: 29 December 2017
In: Radiation oncology
Year: 2017, Volume: 12, Pages: 1-8
ISSN:1748-717X
DOI:10.1186/s13014-017-0939-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13014-017-0939-0
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Author Notes:Carmen Klein, Ivana Dokic, Andrea Mairani, Stewart Mein, Stephan Brons, Peter Häring, Thomas Haberer, Oliver Jäkel, Astrid Zimmermann, Frank Zenke, Andree Blaukat, Jürgen Debus and Amir Abdollahi
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Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation by Klein, Carmen (Author) , Dokić, Ivana (Author) , Mairani, Andrea (Author) , Mein, Stewart (Author) , Brons, Stephan (Author) , Haberer, Thomas (Author) , Jäkel, Oliver (Author) , Debus, Jürgen (Author) , Abdollahi, Amir (Author) ,

BioMed Central 29 December 2017

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