The glycobiology of the CD system: a dictionary for translating marker designations into glycan/lectin structure and function
The profile of cell surface molecules, the biochemical platform for cellular communication, can be likened to a molecular fingerprint. Historically, raising monoclonal antibodies by immunization with cells has been instrumental in obtaining tools suited for phenotyping and functional analysis. Initi...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
14 May 2015
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| In: |
Trends in biochemical sciences
Year: 2015, Volume: 40, Issue: 7, Pages: 360-376 |
| ISSN: | 1362-4326 |
| DOI: | 10.1016/j.tibs.2015.03.013 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tibs.2015.03.013 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0968000415000626 
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| Author Notes: | Hans-Joachim Gabius, Herbert Kaltner, Jürgen Kopitz, and Sabine André |
| Summary: | The profile of cell surface molecules, the biochemical platform for cellular communication, can be likened to a molecular fingerprint. Historically, raising monoclonal antibodies by immunization with cells has been instrumental in obtaining tools suited for phenotyping and functional analysis. Initially for leukocyte antigens, the resulting cluster of differentiation (CD) nomenclature has become a popular system for classification. Glycans presented on proteins or lipids and receptors for carbohydrate structures (lectins) are part of the CD list. Our review presents biochemical and biomedical highlights of the respective CD entries. |
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| Item Description: | Gesehen am 06.08.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1362-4326 |
| DOI: | 10.1016/j.tibs.2015.03.013 |