GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration
Oligodendrocyte precursor cells (OPCs) are essential for developmental myelination and oligodendrocyte regeneration after CNS injury. These progenitors express calcium-permeable AMPA receptors (AMPARs) and form direct synapses with neurons throughout the CNS, but the roles of this signaling are uncl...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 May 2021
|
| In: |
Cell reports
Year: 2021, Volume: 35, Issue: 7, Pages: 1-15, e1-e6 |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2021.109147 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.celrep.2021.109147 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2211124721004861 
|
| Author Notes: | Rabia R. Khawaja, Amit Agarwal, Masahiro Fukaya, Hey-Kyeong Jeong, Scott Gross, Estibaliz Gonzalez-Fernandez, Jonathan Soboloff, Dwight E. Bergles, and Shin H. Kang |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1766152465 | ||
| 003 | DE-627 | ||
| 005 | 20240414193256.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210811s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.celrep.2021.109147 |2 doi | |
| 035 | |a (DE-627)1766152465 | ||
| 035 | |a (DE-599)KXP1766152465 | ||
| 035 | |a (OCoLC)1341420385 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Khawaja, Rabia R. |e VerfasserIn |0 (DE-588)1238733670 |0 (DE-627)1766153194 |4 aut | |
| 245 | 1 | 0 | |a GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration |c Rabia R. Khawaja, Amit Agarwal, Masahiro Fukaya, Hey-Kyeong Jeong, Scott Gross, Estibaliz Gonzalez-Fernandez, Jonathan Soboloff, Dwight E. Bergles, and Shin H. Kang |
| 264 | 1 | |c 18 May 2021 | |
| 300 | |a 21 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.08.2021 | ||
| 520 | |a Oligodendrocyte precursor cells (OPCs) are essential for developmental myelination and oligodendrocyte regeneration after CNS injury. These progenitors express calcium-permeable AMPA receptors (AMPARs) and form direct synapses with neurons throughout the CNS, but the roles of this signaling are unclear. To enable selective alteration of the properties of AMPARs in oligodendroglia, we generate mice that allow cell-specific overexpression of EGFP-GluA2 in vivo. In healthy conditions, OPC-specific GluA2 overexpression significantly increase their proliferation in an age-dependent manner but did not alter their rate of differentiation into oligodendrocytes. In contrast, after demyelinating brain injury in neonates or adults, higher GluA2 levels promote both OPC proliferation and oligodendrocyte regeneration, but do not prevent injury-induced initial cell loss. These findings indicate that AMPAR GluA2 content regulates the proliferative and regenerative behavior of adult OPCs, serving as a putative target for better myelin repair. | ||
| 650 | 4 | |a AMPA receptor | |
| 650 | 4 | |a calcium | |
| 650 | 4 | |a GluA2 | |
| 650 | 4 | |a hypoxic-ischemia | |
| 650 | 4 | |a injury | |
| 650 | 4 | |a oligodendrocyte | |
| 650 | 4 | |a OPC | |
| 650 | 4 | |a remyelination | |
| 700 | 1 | |a Agarwal, Amit |d 1980- |e VerfasserIn |0 (DE-588)141971606 |0 (DE-627)704109522 |0 (DE-576)327136677 |4 aut | |
| 700 | 1 | |a Fukaya, Masahiro |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jeong, Hey-Kyeong |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gross, Scott |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gonzalez-Fernandez, Estibaliz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Soboloff, Jonathan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bergles, Dwight E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kang, Shin H. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell reports |d Maryland Heights, MO : Cell Press, 2012 |g 35(2021), 7, Artikel-ID 109147, Seite 1-15, e1-e6 |h Online-Ressource |w (DE-627)684964562 |w (DE-600)2649101-1 |w (DE-576)358411572 |x 2211-1247 |7 nnas |a GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration |
| 773 | 1 | 8 | |g volume:35 |g year:2021 |g number:7 |g elocationid:109147 |g pages:1-15, e1-e6 |g extent:21 |a GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.celrep.2021.109147 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S2211124721004861 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210811 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 141971606 |a Agarwal, Amit |m 141971606:Agarwal, Amit |d 50000 |d 53100 |e 50000PA141971606 |e 53100PA141971606 |k 0/50000/ |k 1/50000/53100/ |p 2 | ||
| 999 | |a KXP-PPN1766152465 |e 3965402161 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Rabia R. Khawaja, Amit Agarwal, Masahiro Fukaya, Hey-Kyeong Jeong, Scott Gross, Estibaliz Gonzalez-Fernandez, Jonathan Soboloff, Dwight E. Bergles, and Shin H. Kang"]},"physDesc":[{"extent":"21 S."}],"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"18 May 2021"}],"note":["Gesehen am 11.08.2021"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1766152465","language":["eng"],"title":[{"title":"GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration","title_sort":"GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration"}],"id":{"doi":["10.1016/j.celrep.2021.109147"],"eki":["1766152465"]},"relHost":[{"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"publisherPlace":"Maryland Heights, MO ; [New York, NY]","dateIssuedDisp":"2012-","dateIssuedKey":"2012","publisher":"Cell Press ; Elsevier"}],"pubHistory":["1.2012 -"],"title":[{"title":"Cell reports","title_sort":"Cell reports"}],"recId":"684964562","language":["eng"],"disp":"GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regenerationCell reports","physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"35","text":"35(2021), 7, Artikel-ID 109147, Seite 1-15, e1-e6","year":"2021","pages":"1-15, e1-e6","issue":"7","extent":"21"},"id":{"issn":["2211-1247"],"eki":["684964562"],"zdb":["2649101-1"]}}],"person":[{"family":"Khawaja","given":"Rabia R.","roleDisplay":"VerfasserIn","role":"aut","display":"Khawaja, Rabia R."},{"given":"Amit","family":"Agarwal","roleDisplay":"VerfasserIn","role":"aut","display":"Agarwal, Amit"},{"display":"Fukaya, Masahiro","roleDisplay":"VerfasserIn","role":"aut","given":"Masahiro","family":"Fukaya"},{"display":"Jeong, Hey-Kyeong","given":"Hey-Kyeong","family":"Jeong","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Gross, Scott","role":"aut","roleDisplay":"VerfasserIn","family":"Gross","given":"Scott"},{"role":"aut","roleDisplay":"VerfasserIn","family":"Gonzalez-Fernandez","given":"Estibaliz","display":"Gonzalez-Fernandez, Estibaliz"},{"display":"Soboloff, Jonathan","role":"aut","roleDisplay":"VerfasserIn","given":"Jonathan","family":"Soboloff"},{"display":"Bergles, Dwight E.","roleDisplay":"VerfasserIn","role":"aut","family":"Bergles","given":"Dwight E."},{"role":"aut","roleDisplay":"VerfasserIn","family":"Kang","given":"Shin H.","display":"Kang, Shin H."}]} | ||
| SRT | |a KHAWAJARABGLUA2OVERE1820 | ||