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Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function and pharm...

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Main Authors: Wahis, Jérôme (Author) , Baudon, Angel (Author) , Althammer, Ferdinand (Author) , Kerspern, Damien (Author) , Goyon, Stéphanie (Author) , Hagiwara, Daisuke (Author) , Lefevre, Arthur (Author) , Barteczko, Lara (Author) , Boury-Jamot, Benjamin (Author) , Bellanger, Benjamin (Author) , Abatis, Marios (Author) , Da Silva Gouveia, Miriam (Author) , Benusiglio, Diego (Author) , Eliava, Marina (Author) , Rozov, Andrei (Author) , Weinsanto, Ivan (Author) , Knobloch-Bollmann, Hanna Sophie (Author) , Kirchner, Matthew K. (Author) , Roy, Ranjan K. (Author) , Wang, Hong (Author) , Pertin, Marie (Author) , Inquimbert, Perrine (Author) , Pitzer, Claudia (Author) , Siemens, Jan (Author) , Goumon, Yannick (Author) , Boutrel, Benjamin (Author) , Lamy, Christophe Maurice (Author) , Decosterd, Isabelle (Author) , Chatton, Jean-Yves (Author) , Rouach, Nathalie (Author) , Young, W. Scott (Author) , Stern, Javier E. (Author) , Poisbeau, Pierrick (Author) , Stoop, Ron (Author) , Darbon, Pascal (Author) , Grinevich, Valery (Author) , Charlet, Alexandre (Author)
Format: Article (Journal)
Language:English
Published: 15 February 2021
In: Nature neuroscience
Year: 2021, Volume: 24, Issue: 4, Pages: 529-541
ISSN:1546-1726
DOI:10.1038/s41593-021-00800-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41593-021-00800-0
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41593-021-00800-0
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Author Notes:Jérôme Wahis, Angel Baudon, Ferdinand Althammer, Damien Kerspern, Stéphanie Goyon, Daisuke Hagiwara, Arthur Lefevre, Lara Barteczko, Benjamin Boury-Jamot, Benjamin Bellanger, Marios Abatis, Miriam Da Silva Gouveia, Diego Benusiglio, Marina Eliava, Andrei Rozov, Ivan Weinsanto, Hanna Sophie Knobloch-Bollmann, Matthew K. Kirchner, Ranjan K. Roy, Hong Wang, Marie Pertin, Perrine Inquimbert, Claudia Pitzer, Jan Siemens, Yannick Goumon, Benjamin Boutrel, Christophe Maurice Lamy, Isabelle Decosterd, Jean-Yves Chatton, Nathalie Rouach, W. Scott Young, Javier E. Stern, Pierrick Poisbeau, Ron Stoop, Pascal Darbon, Valery Grinevich and Alexandre Charlet
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Summary:Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes expresses OT receptors and mediates anxiolytic and positive reinforcement effects of OT in the central amygdala of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlights astrocytes as essential components for modulation of emotional states under normal and chronic pain conditions.
Item Description:Gesehen am 11.08.2021
Physical Description:Online Resource
ISSN:1546-1726
DOI:10.1038/s41593-021-00800-0

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