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Hox dosage contributes to flight appendage morphology in Drosophila

Flying insects have invaded all the aerial space on Earth and this astonishing radiation could not have been possible without a remarkable morphological diversification of their flight appendages. Here, we show that characteristic spatial expression profiles and levels of the Hox genes Antennapedia...

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Hauptverfasser: Paul, Rachel (VerfasserIn) , Giraud, Guillaume (VerfasserIn) , Domsch, Katrin (VerfasserIn) , Duffraisse, Marilyne (VerfasserIn) , Marmigère, Frédéric (VerfasserIn) , Khan, Soumen (VerfasserIn) , Vanderperre, Solene (VerfasserIn) , Lohmann, Ingrid (VerfasserIn) , Stoks, Robby (VerfasserIn) , Shashidhara, L. S. (VerfasserIn) , Merabet, Samir (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 17 May 2021
In: Nature Communications
Year: 2021, Jahrgang: 12, Pages: 1-13
ISSN:2041-1723
DOI:10.1038/s41467-021-23293-8
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-021-23293-8
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-021-23293-8
Volltext
Verfasserangaben:Rachel Paul, Guillaume Giraud, Katrin Domsch, Marilyne Duffraisse, Frédéric Marmigère, Soumen Khan, Solene Vanderperre, Ingrid Lohmann, Robby Stoks, L.S. Shashidhara & Samir Merabet

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520 |a Flying insects have invaded all the aerial space on Earth and this astonishing radiation could not have been possible without a remarkable morphological diversification of their flight appendages. Here, we show that characteristic spatial expression profiles and levels of the Hox genes Antennapedia (Antp) and Ultrabithorax (Ubx) underlie the formation of two different flight organs in the fruit fly Drosophila melanogaster. We further demonstrate that flight appendage morphology is dependent on specific Hox doses. Interestingly, we find that wing morphology from evolutionary distant four-winged insect species is also associated with a differential expression of Antp and Ubx. We propose that variation in the spatial expression profile and dosage of Hox proteins is a major determinant of flight appendage diversification in Drosophila and possibly in other insect species during evolution. 
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