Decoding the microstructural properties of white matter using realistic models
Multi-echo gradient echo (ME-GRE) magnetic resonance signal evolution in white matter has a strong dependence on the orientation of myelinated axons with respect to the main static field. Although analytical solutions have been able to predict some of the white matter (WM) signal behaviour of the ho...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 August 2021
|
| In: |
NeuroImage
Year: 2021, Jahrgang: 237, Pages: 1-15 |
| ISSN: | 1095-9572 |
| DOI: | 10.1016/j.neuroimage.2021.118138 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neuroimage.2021.118138 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1053811921004158 
|
| Verfasserangaben: | Renaud Hédouin, Riccardo Metere, Kwok-Shing Chan, Christian Licht, Jeroen Mollink, Anne-Marievan Cappellen van Walsum, José P. Marques |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 176728599X | ||
| 003 | DE-627 | ||
| 005 | 20220820035604.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210818s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.neuroimage.2021.118138 |2 doi | |
| 035 | |a (DE-627)176728599X | ||
| 035 | |a (DE-599)KXP176728599X | ||
| 035 | |a (OCoLC)1341420891 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hedouin, Renaud |e VerfasserIn |0 (DE-588)1239210698 |0 (DE-627)1767285914 |4 aut | |
| 245 | 1 | 0 | |a Decoding the microstructural properties of white matter using realistic models |c Renaud Hédouin, Riccardo Metere, Kwok-Shing Chan, Christian Licht, Jeroen Mollink, Anne-Marievan Cappellen van Walsum, José P. Marques |
| 264 | 1 | |c 15 August 2021 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 18.08.2021 | ||
| 520 | |a Multi-echo gradient echo (ME-GRE) magnetic resonance signal evolution in white matter has a strong dependence on the orientation of myelinated axons with respect to the main static field. Although analytical solutions have been able to predict some of the white matter (WM) signal behaviour of the hollow cylinder model, it has been shown that realistic models of WM offer a better description of the signal behaviour observed. In this work, we present a pipeline to (i) generate realistic 2D WM models with their microstructure based on real axon morphology with adjustable fiber volume fraction (FVF) and g-ratio. We (ii) simulate their interaction with the static magnetic field to be able to simulate their MR signal. For the first time, we (iii) demonstrate that realistic 2D WM models can be used to simulate a MR signal that provides a good approximation of the signal obtained from a real 3D WM model derived from electron microscopy. We then (iv) demonstrate in silico that 2D WM models can be used to predict microstructural parameters in a robust way if ME-GRE multi-orientation data is available and the main fiber orientation in each pixel is known using DTI. A deep learning network was trained and characterized in its ability to recover the desired microstructural parameters such as FVF, g-ratio, free and bound water transverse relaxation and magnetic susceptibility. Finally, the network was trained to recover these micro-structural parameters from an ex vivo dataset acquired in 9 orientations with respect to the magnetic field and 12 echo times. We demonstrate that this is an overdetermined problem and that as few as 3 orientations can already provide comparable results for some of the decoded metrics. | ||
| 650 | 4 | |a Deep learning network | |
| 650 | 4 | |a Magnetic susceptibility | |
| 650 | 4 | |a Microstructural properties | |
| 650 | 4 | |a White matter models | |
| 700 | 1 | |a Metere, Riccardo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chan, Kwok-Shing |e VerfasserIn |4 aut | |
| 700 | 1 | |a Licht, Christian |d 1993- |e VerfasserIn |0 (DE-588)1239210566 |0 (DE-627)1767285639 |4 aut | |
| 700 | 1 | |a Mollink, Jeroen |e VerfasserIn |4 aut | |
| 700 | 1 | |a van Walsum, Anne-Marievan Cappellen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Marques, José P. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t NeuroImage |d Orlando, Fla. : Academic Press, 1992 |g 237(2021), Artikel-ID 118138, Seite 1-15 |h Online-Ressource |w (DE-627)268125503 |w (DE-600)1471418-8 |w (DE-576)106869507 |x 1095-9572 |7 nnas |a Decoding the microstructural properties of white matter using realistic models |
| 773 | 1 | 8 | |g volume:237 |g year:2021 |g elocationid:118138 |g pages:1-15 |g extent:15 |a Decoding the microstructural properties of white matter using realistic models |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.neuroimage.2021.118138 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1053811921004158 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210818 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1239210566 |a Licht, Christian |m 1239210566:Licht, Christian |p 4 | ||
| 999 | |a KXP-PPN176728599X |e 3969788633 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Renaud Hédouin, Riccardo Metere, Kwok-Shing Chan, Christian Licht, Jeroen Mollink, Anne-Marievan Cappellen van Walsum, José P. Marques"]},"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"15 August 2021"}],"id":{"eki":["176728599X"],"doi":["10.1016/j.neuroimage.2021.118138"]},"physDesc":[{"extent":"15 S."}],"relHost":[{"title":[{"title_sort":"NeuroImage","subtitle":"a journal of brain function","title":"NeuroImage"}],"pubHistory":["Volume 1, issue 1 (august 1992)-"],"part":{"year":"2021","pages":"1-15","text":"237(2021), Artikel-ID 118138, Seite 1-15","volume":"237","extent":"15"},"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Fortsetzung der Druck-Ausgabe","Gesehen am 29.06.20"],"disp":"Decoding the microstructural properties of white matter using realistic modelsNeuroImage","recId":"268125503","language":["eng"],"origin":[{"dateIssuedDisp":"[1992]-","publisher":"Academic Press","publisherPlace":"Orlando, Fla."}],"id":{"eki":["268125503"],"zdb":["1471418-8"],"issn":["1095-9572"]},"physDesc":[{"extent":"Online-Ressource"}]}],"person":[{"role":"aut","display":"Hedouin, Renaud","roleDisplay":"VerfasserIn","given":"Renaud","family":"Hedouin"},{"family":"Metere","given":"Riccardo","roleDisplay":"VerfasserIn","display":"Metere, Riccardo","role":"aut"},{"role":"aut","display":"Chan, Kwok-Shing","roleDisplay":"VerfasserIn","given":"Kwok-Shing","family":"Chan"},{"family":"Licht","given":"Christian","roleDisplay":"VerfasserIn","display":"Licht, Christian","role":"aut"},{"given":"Jeroen","family":"Mollink","role":"aut","roleDisplay":"VerfasserIn","display":"Mollink, Jeroen"},{"display":"van Walsum, Anne-Marievan Cappellen","roleDisplay":"VerfasserIn","role":"aut","family":"van Walsum","given":"Anne-Marievan Cappellen"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Marques, José P.","given":"José P.","family":"Marques"}],"title":[{"title_sort":"Decoding the microstructural properties of white matter using realistic models","title":"Decoding the microstructural properties of white matter using realistic models"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 18.08.2021"],"recId":"176728599X","language":["eng"]} | ||
| SRT | |a HEDOUINRENDECODINGTH1520 | ||