68Ga-FAPI-PET/CT improves diagnostic staging and radiotherapy planning of adenoid cystic carcinomas: imaging analysis and histological validation
Background - Adenoid cystic carcinomas (ACCs) are rare epithelial tumors mostly situated in the head and neck region and characterized by infiltrative growth. The tumor stroma of ACCs includes cancer-associated fibroblasts (CAFs) expressing Fibroblast Activation Protein (FAP), a new target for posit...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 May 2021
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| In: |
Radiotherapy and oncology
Year: 2021, Jahrgang: 160, Pages: 192-201 |
| ISSN: | 1879-0887 |
| DOI: | 10.1016/j.radonc.2021.04.016 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radonc.2021.04.016 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814021062137 
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| Verfasserangaben: | Manuel Röhrich, Mustafa Syed, Dawn P. Liew, Frederik L. Giesel, Jakob Liermann, Peter L. Choyke, Annika K. Wefers, Thomas Ritz, Marina Szymbara, Lisa Schillings, Ulrike Heger, Hendrik Rathke, Clemens Kratochwil, Peter E. Huber, Andreas von Deimling, Jürgen Debus, Hans-Ulrich Kauczor, Uwe Haberkorn, Sebastian Adeberg |
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| 245 | 1 | 0 | |a 68Ga-FAPI-PET/CT improves diagnostic staging and radiotherapy planning of adenoid cystic carcinomas |b imaging analysis and histological validation |c Manuel Röhrich, Mustafa Syed, Dawn P. Liew, Frederik L. Giesel, Jakob Liermann, Peter L. Choyke, Annika K. Wefers, Thomas Ritz, Marina Szymbara, Lisa Schillings, Ulrike Heger, Hendrik Rathke, Clemens Kratochwil, Peter E. Huber, Andreas von Deimling, Jürgen Debus, Hans-Ulrich Kauczor, Uwe Haberkorn, Sebastian Adeberg |
| 246 | 3 | 3 | |a 68 Ga-FAPI-PET/CT improves diagnostic staging and radiotherapy planning of adenoid cystic carcinomas |
| 264 | 1 | |c 1 May 2021 | |
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| 520 | |a Background - Adenoid cystic carcinomas (ACCs) are rare epithelial tumors mostly situated in the head and neck region and characterized by infiltrative growth. The tumor stroma of ACCs includes cancer-associated fibroblasts (CAFs) expressing Fibroblast Activation Protein (FAP), a new target for positron emission tomography (PET) imaging. Here we describe the value of PET/ computed tomography (PET/CT) imaging using 68Ga-labelled FAP-Inhibitors (68Ga-FAPI-PET/CT) and their clinical potential for staging and radiotherapy planning in 12 ACC patients (7 primary, 5 recurrent). - Patients and methods - Patients underwent contrast enhanced staging CT (ceCT) and magnetic resonance imaging (ceMRI) before 68Ga-FAPI - PET/CT. PET-scans were acquired 10, 60 and 180 minutes after administration of 150-250 MBq of 68Ga-labelled FAPI tracers. SUVmax and SUVmean values of ACCs and healthy organs were obtained using a 60% of maximum iso-contour. FAP and alpha smooth muscle actin (α-SMA) immunohistochemistry was performed in 13 cases (3 with and 10 without 68Ga FAPI-PET/CT). Staging and radiotherapy planning based on 68Ga-FAPI-PET/CT versus ceCT/MRI alone were compared. - Results - We observed elevated tracer uptake in all ACCs. Immunohistochemistry showed FAP-expressing CAFs in the tumor. Compared to conventional staging, 68Ga-FAPI-PET/CT led to upstaging in 2/12 patients and to detection of additional metastases in 3 patients, thus in total 42% of patients had their staging altered. Moreover, 68Ga-FAPI PET improved the accuracy of target volume delineation for radiotherapy, as compared to CT and MRI. - Conclusion - 68Ga-FAPI-PET/CT is a promising imaging modality for ACC, increasing the accuracy of staging exams and radiotherapy planning volumes, as compared conventional to CT and MRI. | ||
| 650 | 4 | |a ACC | |
| 650 | 4 | |a Adenoid cystic carcinoma | |
| 650 | 4 | |a FAP | |
| 650 | 4 | |a Fibroblast Activation Protein | |
| 650 | 4 | |a Positron Emission Tomography | |
| 650 | 4 | |a Radiotherapy | |
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