Antitumor effect of paclitaxel is mediated by inhibition of myeloid-derived suppressor cells and chronic inflammation in the spontaneous melanoma model

The antitumor effects of paclitaxel are generally attributed to the suppression of microtubule dynamics resulting in defects in cell division. New data demonstrated that in ultralow noncytotoxic concentrations, paclitaxel modulated in immune cells in vitro the activity of small Rho GTPases, the key...

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Bibliographic Details

Main Authors:	Sevko, Alexandra (Author) , Michels, Tillmann (Author) , Vrohlings, Melissa (Author) , Umansky, Ludmila (Author) , Beckhove, Philipp (Author) , Kato, Masashi (Author) , Shurin, Galina V. (Author) , Shurin, Michael R. (Author) , Umansky, Viktor (Author)
Format:	Article (Journal)
Language:	English
Published:	28 January 2013
In:	The journal of immunology Year: 2013, Volume: 190, Issue: 5, Pages: 2464-2471
ISSN:	1550-6606
DOI:	10.4049/jimmunol.1202781
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4049/jimmunol.1202781 Verlag, lizenzpflichtig, Volltext: https://www.jimmunol.org/content/190/5/2464
Author Notes:	Alexandra Sevko, Tillmann Michels, Melissa Vrohlings, Ludmila Umansky, Philipp Beckhove, Masashi Kato, Galina V. Shurin, Michael R. Shurin, and Viktor Umansky