The impact of allogeneic hematopoietic cell transplantation on the mortality of poor-risk non-Hodgkin lymphoma: an intent-to-transplant analysis
Purpose of this single-centre retrospective study was to assess the outcome of allogeneic hematopoietic cell transplantation (alloHCT) for relapsed/refractory (r/r) non-Hodgkin lymphoma (NHL) by intent-to-transplant (ITT). Included were all consecutive patients with diffuse large B-cell lymphoma (DL...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2021
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| In: |
Bone marrow transplantation
Year: 2021, Jahrgang: 56, Heft: 1, Pages: 30-37 |
| ISSN: | 1476-5365 |
| DOI: | 10.1038/s41409-020-0976-4 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41409-020-0976-4 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41409-020-0976-4 
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| Verfasserangaben: | Lorenz Selberg, Peter Stadtherr, Sascha Dietrich, T. Hien Tran, Thomas Luft, Ute Hegenbart, Andrea Bondong, Julia Meissner, Nora Liebers, Michael Schmitt, Anthony Dick Ho, Carsten Müller-Tidow, Peter Dreger |
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| 245 | 1 | 4 | |a The impact of allogeneic hematopoietic cell transplantation on the mortality of poor-risk non-Hodgkin lymphoma |b an intent-to-transplant analysis |c Lorenz Selberg, Peter Stadtherr, Sascha Dietrich, T. Hien Tran, Thomas Luft, Ute Hegenbart, Andrea Bondong, Julia Meissner, Nora Liebers, Michael Schmitt, Anthony Dick Ho, Carsten Müller-Tidow, Peter Dreger |
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| 520 | |a Purpose of this single-centre retrospective study was to assess the outcome of allogeneic hematopoietic cell transplantation (alloHCT) for relapsed/refractory (r/r) non-Hodgkin lymphoma (NHL) by intent-to-transplant (ITT). Included were all consecutive patients with diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), mantle cell lymphoma (MCL), and peripheral T-cell lymphoma (PTCL) for whom a donor search was performed between 2004 and 2018. Primary endpoint was overall survival (OS) measured from search initiation. A donor search was initiated for 189 patients (DLBCL 61, FL 32, MCL 43, and PTCL 53), with 76% of the patients having active disease. OS at 5 years after search initiation for DLBCL, FL, MCL, and PTCL was 26%, 44%, 52%, and 50%, respectively. AlloHCT was performed in 137 patients (72%; DLBCL 64%). Main reason for not undergoing alloHCT was disease progression, whereas donor unavailability accounted for only 4% of pretransplantation failures. These results suggest that survival of patients with r/r NHL entering the alloHCT route may be overestimated by a factor of 1.2-1.4 if based on actually transplanted patients only. This effect should be taken into account when using alloHCT as benchmark for new therapeutic approaches for the treatment of poor-risk NHL. | ||
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