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Clinical profile and predictors of in-hospital mortality among older patients hospitalised for COVID-19

the coronavirus disease 2019 (COVID-19) is characterized by poor outcomes and mortality, particularly in older patients.post hoc analysis of the international, multicentre, ‘real-world’ HOPE COVID-19 registry. All patients aged ≥65 years hospitalised for COVID-19 were selected. Epidemiological, clin...

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Main Authors: Becerra-Muñoz, Víctor Manuel (Author) , Núñez-Gil, Iván J (Author) , Eid, Charbel Maroun (Author) , García Aguado, Marcos (Author) , Romero, Rodolfo (Author) , Huang, Jia (Author) , Mulet, Alba (Author) , Ugo, Fabrizio (Author) , Rametta, Francesco (Author) , Liebetrau, Christoph (Author) , Aparisi, Alvaro (Author) , Fernández-Rozas, Inmaculada (Author) , Viana-Llamas, María C (Author) , Feltes, Gisela (Author) , Pepe, Martino (Author) , Moreno-Rondón, Luis A (Author) , Cerrato, Enrico (Author) , Raposeiras-Roubín, Sergio (Author) , Alfonso, Emilio (Author) , Carrero-Fernández, Ana (Author) , Buzón-Martín, Luis (Author) , Abumayyaleh, Mohammad S. A. (Author) , Gonzalez, Adelina (Author) , Fernández Ortiz, Antonio (Author) , Macaya, Carlos (Author) , Estrada, Vicente (Author) , Fernández-Pérez, Cristina (Author) , Gómez-Doblas, Juan José (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Age & ageing
Year: 2021, Volume: 50, Issue: 2, Pages: 326-334
ISSN:1468-2834
DOI:10.1093/ageing/afaa258
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/ageing/afaa258
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Author Notes:Víctor Manuel Becerra-Muñoz, Iván J. Núñez-Gil, Charbel Maroun Eid, Marcos García Aguado, Rodolfo Romero, Jia Huang, Alba Mulet, Fabrizio Ugo, Francesco Rametta, Christoph Liebetrau, Alvaro Aparisi, Inmaculada Fernández-Rozas, María C. Viana-Llamas, Gisela Feltes, Martino Pepe, Luis A. Moreno-Rondón, Enrico Cerrato, Sergio Raposeiras-Roubín, Emilio Alfonso, Ana Carrero-Fernández, Luis Buzón-Martín, Mohammad Abumayyaleh, Adelina Gonzalez, Antonio Fernández Ortiz, Carlos Macaya, Vicente Estrada, Cristina Fernández-Pérez, Juan José Gómez-Doblas
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Summary:the coronavirus disease 2019 (COVID-19) is characterized by poor outcomes and mortality, particularly in older patients.post hoc analysis of the international, multicentre, ‘real-world’ HOPE COVID-19 registry. All patients aged ≥65 years hospitalised for COVID-19 were selected. Epidemiological, clinical, analytical and outcome data were obtained. A comparative study between two age subgroups, 65-74 and ≥75 years, was performed. The primary endpoint was all cause in-hospital mortality.about, 1,520 patients aged ≥65 years (60.3% male, median age of 76 [IQR 71-83] years) were included. Comorbidities such as hypertension (69.2%), dyslipidaemia (48.6%), cardiovascular diseases (any chronic heart disease in 38.4% and cerebrovascular disease in 12.5%), and chronic lung disease (25.3%) were prevalent, and 49.6% were on ACEI/ARBs. Patients aged 75 years and older suffered more in-hospital complications (respiratory failure, heart failure, renal failure, sepsis) and a significantly higher mortality (18.4 vs. 48.2%, P < 0.001), but fewer admissions to intensive care units (11.2 vs. 4.8%). In the overall cohort, multivariable analysis demonstrated age ≥75 (OR 3.54), chronic kidney disease (OR 3.36), dementia (OR 8.06), peripheral oxygen saturation at admission <92% (OR 5.85), severe lymphopenia (<500/mm3) (OR 3.36) and qSOFA (Quick Sequential Organ Failure Assessment Score) >1 (OR 8.31) to be independent predictors of mortality.patients aged ≥65 years hospitalised for COVID-19 had high rates of in-hospital complications and mortality, especially among patients 75 years or older. Age ≥75 years, dementia, peripheral oxygen saturation <92%, severe lymphopenia and qSOFA scale >1 were independent predictors of mortality in this population.
Item Description:Published: 17 November 2020
Gesehen am 13.09.2021
Physical Description:Online Resource
ISSN:1468-2834
DOI:10.1093/ageing/afaa258

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