Clinical profile and predictors of in-hospital mortality among older patients hospitalised for COVID-19
the coronavirus disease 2019 (COVID-19) is characterized by poor outcomes and mortality, particularly in older patients.post hoc analysis of the international, multicentre, ‘real-world’ HOPE COVID-19 registry. All patients aged ≥65 years hospitalised for COVID-19 were selected. Epidemiological, clin...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2021
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| In: |
Age & ageing
Year: 2021, Jahrgang: 50, Heft: 2, Pages: 326-334 |
| ISSN: | 1468-2834 |
| DOI: | 10.1093/ageing/afaa258 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/ageing/afaa258
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| Verfasserangaben: | Víctor Manuel Becerra-Muñoz, Iván J. Núñez-Gil, Charbel Maroun Eid, Marcos García Aguado, Rodolfo Romero, Jia Huang, Alba Mulet, Fabrizio Ugo, Francesco Rametta, Christoph Liebetrau, Alvaro Aparisi, Inmaculada Fernández-Rozas, María C. Viana-Llamas, Gisela Feltes, Martino Pepe, Luis A. Moreno-Rondón, Enrico Cerrato, Sergio Raposeiras-Roubín, Emilio Alfonso, Ana Carrero-Fernández, Luis Buzón-Martín, Mohammad Abumayyaleh, Adelina Gonzalez, Antonio Fernández Ortiz, Carlos Macaya, Vicente Estrada, Cristina Fernández-Pérez, Juan José Gómez-Doblas |
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| 245 | 1 | 0 | |a Clinical profile and predictors of in-hospital mortality among older patients hospitalised for COVID-19 |c Víctor Manuel Becerra-Muñoz, Iván J. Núñez-Gil, Charbel Maroun Eid, Marcos García Aguado, Rodolfo Romero, Jia Huang, Alba Mulet, Fabrizio Ugo, Francesco Rametta, Christoph Liebetrau, Alvaro Aparisi, Inmaculada Fernández-Rozas, María C. Viana-Llamas, Gisela Feltes, Martino Pepe, Luis A. Moreno-Rondón, Enrico Cerrato, Sergio Raposeiras-Roubín, Emilio Alfonso, Ana Carrero-Fernández, Luis Buzón-Martín, Mohammad Abumayyaleh, Adelina Gonzalez, Antonio Fernández Ortiz, Carlos Macaya, Vicente Estrada, Cristina Fernández-Pérez, Juan José Gómez-Doblas |
| 246 | 3 | 3 | |a Clinical profile and predictors of in-hospital mortality among older patients hospitalised for COVID-nineteen |
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| 520 | |a the coronavirus disease 2019 (COVID-19) is characterized by poor outcomes and mortality, particularly in older patients.post hoc analysis of the international, multicentre, ‘real-world’ HOPE COVID-19 registry. All patients aged ≥65 years hospitalised for COVID-19 were selected. Epidemiological, clinical, analytical and outcome data were obtained. A comparative study between two age subgroups, 65-74 and ≥75 years, was performed. The primary endpoint was all cause in-hospital mortality.about, 1,520 patients aged ≥65 years (60.3% male, median age of 76 [IQR 71-83] years) were included. Comorbidities such as hypertension (69.2%), dyslipidaemia (48.6%), cardiovascular diseases (any chronic heart disease in 38.4% and cerebrovascular disease in 12.5%), and chronic lung disease (25.3%) were prevalent, and 49.6% were on ACEI/ARBs. Patients aged 75 years and older suffered more in-hospital complications (respiratory failure, heart failure, renal failure, sepsis) and a significantly higher mortality (18.4 vs. 48.2%, P < 0.001), but fewer admissions to intensive care units (11.2 vs. 4.8%). In the overall cohort, multivariable analysis demonstrated age ≥75 (OR 3.54), chronic kidney disease (OR 3.36), dementia (OR 8.06), peripheral oxygen saturation at admission <92% (OR 5.85), severe lymphopenia (<500/mm3) (OR 3.36) and qSOFA (Quick Sequential Organ Failure Assessment Score) >1 (OR 8.31) to be independent predictors of mortality.patients aged ≥65 years hospitalised for COVID-19 had high rates of in-hospital complications and mortality, especially among patients 75 years or older. Age ≥75 years, dementia, peripheral oxygen saturation <92%, severe lymphopenia and qSOFA scale >1 were independent predictors of mortality in this population. | ||
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| 700 | 1 | |a Romero, Rodolfo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Huang, Jia |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Pepe, Martino |e VerfasserIn |4 aut | |
| 700 | 1 | |a Moreno-Rondón, Luis A |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cerrato, Enrico |e VerfasserIn |4 aut | |
| 700 | 1 | |a Raposeiras-Roubín, Sergio |e VerfasserIn |4 aut | |
| 700 | 1 | |a Alfonso, Emilio |e VerfasserIn |4 aut | |
| 700 | 1 | |a Carrero-Fernández, Ana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Buzón-Martín, Luis |e VerfasserIn |4 aut | |
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