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Adenoid cystic carcinoma and carbon ion only irradiation (ACCO): study protocol for a prospective, open, randomized, two-armed, phase II study

Adenoid cystic carcinoma is a rare form of head and neck cancer with a slow, but aggressive growth pattern which remains a challenge for local tumor control. Based on phase II data, radiation treatment using partially high LET radiation results in a prolonged PFS and OS. There is a paucity of random...

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Bibliographic Details
Main Authors: Uzun-Lang, Kristin (Author) , Adeberg, Sebastian (Author) , Harrabi, Semi B. (Author) , Held, Thomas (Author) , Kieser, Meinhard (Author) , Debus, Jürgen (Author) , Herfarth, Klaus (Author)
Format: Article (Journal)
Language:English
Published: 15 July 2021
In: BMC cancer
Year: 2021, Volume: 21, Pages: 1-8
ISSN:1471-2407
DOI:10.1186/s12885-021-08473-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12885-021-08473-5
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Author Notes:Kristin Lang, Sebastian Adeberg, Semi Harrabi, Thomas Held, Meinhard Kieser, Jürgen Debus and Klaus Herfarth
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Summary:Adenoid cystic carcinoma is a rare form of head and neck cancer with a slow, but aggressive growth pattern which remains a challenge for local tumor control. Based on phase II data, radiation treatment using partially high LET radiation results in a prolonged PFS and OS. There is a paucity of randomized clinical data examining the role of the use of high LET radiation only. Therefore, the purpose of this prospective clinical trial is to analyze local control rates in patients with node negative ACC treated with carbon ion radiotherapy alone compared to a combined modality approach.
Item Description:Gesehen am 15.09.2021
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-021-08473-5

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