The relevance of small airway dysfunction in asthma with nocturnal symptoms
Rationale: Small airway dysfunction (SAD) is a frequent feature of asthma that has been linked to disease severity and poor symptom control. However, little is known about the role of SAD in nocturnal asthma. Objective: To study the association between the severity of SAD and frequency of nocturnal...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 July 2021
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| In: |
Journal of asthma and allergy
Year: 2021, Jahrgang: 14, Pages: 897-905 |
| ISSN: | 1178-6965 |
| DOI: | 10.2147/JAA.S313572 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2147/JAA.S313572 Verlag, lizenzpflichtig, Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.2147%2FJAA.S313572&DestApp=DOI&SrcAppSID=E4kvFEhPmo5xgbiIJtE&SrcJTitle=JOURNAL+OF+ASTHMA+AND+ALLERGY&DestDOIRegistrantName=Dove+Medical+Press 
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| Verfasserangaben: | Mustafa Abdo, Frederik Trinkmann, Anne-Marie Kirsten, Heike Biller, Frauke Pedersen, Benjamin Waschki, Erika Von Mutius, Matthias Volkmar Kopp, Gesine Hansen, Klaus F. Rabe, Thomas Bahmer, Henrik Watz, on behalf of the ALLIANCE study group |
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| 245 | 1 | 4 | |a The relevance of small airway dysfunction in asthma with nocturnal symptoms |c Mustafa Abdo, Frederik Trinkmann, Anne-Marie Kirsten, Heike Biller, Frauke Pedersen, Benjamin Waschki, Erika Von Mutius, Matthias Volkmar Kopp, Gesine Hansen, Klaus F. Rabe, Thomas Bahmer, Henrik Watz, on behalf of the ALLIANCE study group |
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| 520 | |a Rationale: Small airway dysfunction (SAD) is a frequent feature of asthma that has been linked to disease severity and poor symptom control. However, little is known about the role of SAD in nocturnal asthma. Objective: To study the association between the severity of SAD and frequency of nocturnal symptoms compared to conventional lung function testing. Methods: We assessed the frequency of self-reported nocturnal symptoms through the asthma control test. We studied the impact of nocturnal asthma using the Asthma Quality of Life Questionnaire (AQLQ) and the Multidimensional Fatigue Inventory (MFI-20). We assessed the lung function using spirometry, body plethysmography, impulse oscillometry, single and multiple inert gas washout and measured markers of T2-inflammation (blood and sputum eosinophils; fractional exhaled nitric oxide (FeNo)). We stratified the patients according to the presence and frequency of nocturnal asthma. Results: A total of 166 asthma patients were enrolled in the analysis. Eighty-seven patients (52%) reported to have nocturnal symptoms at least once in the last four weeks. The odds ratio of nocturnal asthma correlated with the severity of all non-spirometric measures of SAD, yet neither with airflow obstruction (FEV1 and FEV/FVC) nor with large airway resistance (R20). Patients with frequent nocturnal asthma (n = 29) had a numerical increase of T2 markers and more severe SAD, as indicated by all non-spirometric measures of SAD (all p-values < 0.05), worse overall asthma control, increased fatigue and reduced quality of life (all p-values < 0.01) compared to patients with infrequent nocturnal asthma (n = 58) or patients without nocturnal asthma (n = 79). We identified 63 patients without airflow obstruction, nearly 43% of them (n = 27) had nocturnal asthma. In this subgroup, only markers of air trapping and ventilation heterogeneity were significantly elevated and correlated with the frequency of nocturnal symptoms: LCI (Spearman's coefficient = -0.42, p < 0.001), RV% (-0.32, p = 0.02). Conclusion: SAD is closely associated to asthma with nocturnal symptoms. Spirometry might underestimate the broad spectrum of distal lung function impairments in this population of patients. | ||
| 650 | 4 | |a air trapping | |
| 650 | 4 | |a clinical-practice | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a nocturnal asthma | |
| 650 | 4 | |a quality | |
| 650 | 4 | |a responsiveness | |
| 650 | 4 | |a small airway dysfunction | |
| 650 | 4 | |a standardization | |
| 650 | 4 | |a ventilation heterogeneity | |
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| 700 | 1 | |a Waschki, Benjamin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Von Mutius, Erika |e VerfasserIn |4 aut | |
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