The relevance of small airway dysfunction in asthma with nocturnal symptoms
Rationale: Small airway dysfunction (SAD) is a frequent feature of asthma that has been linked to disease severity and poor symptom control. However, little is known about the role of SAD in nocturnal asthma. Objective: To study the association between the severity of SAD and frequency of nocturnal...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
13 July 2021
|
| In: |
Journal of asthma and allergy
Year: 2021, Volume: 14, Pages: 897-905 |
| ISSN: | 1178-6965 |
| DOI: | 10.2147/JAA.S313572 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2147/JAA.S313572 Verlag, lizenzpflichtig, Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.2147%2FJAA.S313572&DestApp=DOI&SrcAppSID=E4kvFEhPmo5xgbiIJtE&SrcJTitle=JOURNAL+OF+ASTHMA+AND+ALLERGY&DestDOIRegistrantName=Dove+Medical+Press 
|
| Author Notes: | Mustafa Abdo, Frederik Trinkmann, Anne-Marie Kirsten, Heike Biller, Frauke Pedersen, Benjamin Waschki, Erika Von Mutius, Matthias Volkmar Kopp, Gesine Hansen, Klaus F. Rabe, Thomas Bahmer, Henrik Watz, on behalf of the ALLIANCE study group |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1770729860 | ||
| 003 | DE-627 | ||
| 005 | 20230427164242.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210915s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2147/JAA.S313572 |2 doi | |
| 035 | |a (DE-627)1770729860 | ||
| 035 | |a (DE-599)KXP1770729860 | ||
| 035 | |a (OCoLC)1341421205 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Abdo, Mustafa |e VerfasserIn |0 (DE-588)1222185571 |0 (DE-627)1741178037 |4 aut | |
| 245 | 1 | 4 | |a The relevance of small airway dysfunction in asthma with nocturnal symptoms |c Mustafa Abdo, Frederik Trinkmann, Anne-Marie Kirsten, Heike Biller, Frauke Pedersen, Benjamin Waschki, Erika Von Mutius, Matthias Volkmar Kopp, Gesine Hansen, Klaus F. Rabe, Thomas Bahmer, Henrik Watz, on behalf of the ALLIANCE study group |
| 264 | 1 | |c 13 July 2021 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.09.2021 | ||
| 520 | |a Rationale: Small airway dysfunction (SAD) is a frequent feature of asthma that has been linked to disease severity and poor symptom control. However, little is known about the role of SAD in nocturnal asthma. Objective: To study the association between the severity of SAD and frequency of nocturnal symptoms compared to conventional lung function testing. Methods: We assessed the frequency of self-reported nocturnal symptoms through the asthma control test. We studied the impact of nocturnal asthma using the Asthma Quality of Life Questionnaire (AQLQ) and the Multidimensional Fatigue Inventory (MFI-20). We assessed the lung function using spirometry, body plethysmography, impulse oscillometry, single and multiple inert gas washout and measured markers of T2-inflammation (blood and sputum eosinophils; fractional exhaled nitric oxide (FeNo)). We stratified the patients according to the presence and frequency of nocturnal asthma. Results: A total of 166 asthma patients were enrolled in the analysis. Eighty-seven patients (52%) reported to have nocturnal symptoms at least once in the last four weeks. The odds ratio of nocturnal asthma correlated with the severity of all non-spirometric measures of SAD, yet neither with airflow obstruction (FEV1 and FEV/FVC) nor with large airway resistance (R20). Patients with frequent nocturnal asthma (n = 29) had a numerical increase of T2 markers and more severe SAD, as indicated by all non-spirometric measures of SAD (all p-values < 0.05), worse overall asthma control, increased fatigue and reduced quality of life (all p-values < 0.01) compared to patients with infrequent nocturnal asthma (n = 58) or patients without nocturnal asthma (n = 79). We identified 63 patients without airflow obstruction, nearly 43% of them (n = 27) had nocturnal asthma. In this subgroup, only markers of air trapping and ventilation heterogeneity were significantly elevated and correlated with the frequency of nocturnal symptoms: LCI (Spearman's coefficient = -0.42, p < 0.001), RV% (-0.32, p = 0.02). Conclusion: SAD is closely associated to asthma with nocturnal symptoms. Spirometry might underestimate the broad spectrum of distal lung function impairments in this population of patients. | ||
| 650 | 4 | |a air trapping | |
| 650 | 4 | |a clinical-practice | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a nocturnal asthma | |
| 650 | 4 | |a quality | |
| 650 | 4 | |a responsiveness | |
| 650 | 4 | |a small airway dysfunction | |
| 650 | 4 | |a standardization | |
| 650 | 4 | |a ventilation heterogeneity | |
| 700 | 1 | |a Trinkmann, Frederik |d 1983- |e VerfasserIn |0 (DE-588)142731773 |0 (DE-627)704298066 |0 (DE-576)332907406 |4 aut | |
| 700 | 1 | |a Kirsten, Anne-Marie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Biller, Heike |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pedersen, Frauke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Waschki, Benjamin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Von Mutius, Erika |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kopp, Matthias Volkmar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hansen, Gesine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rabe, Klaus F. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bahmer, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Watz, Henrik |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of asthma and allergy |d Albany, Auckland : Dove Medical Press, 2008 |g 14(2021), Seite 897-905 |h Online-Ressource |w (DE-627)60030616X |w (DE-600)2494877-9 |w (DE-576)306840758 |x 1178-6965 |7 nnas |a The relevance of small airway dysfunction in asthma with nocturnal symptoms |
| 773 | 1 | 8 | |g volume:14 |g year:2021 |g pages:897-905 |g extent:9 |a The relevance of small airway dysfunction in asthma with nocturnal symptoms |
| 856 | 4 | 0 | |u https://doi.org/10.2147/JAA.S313572 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.2147%2FJAA.S313572&DestApp=DOI&SrcAppSID=E4kvFEhPmo5xgbiIJtE&SrcJTitle=JOURNAL+OF+ASTHMA+AND+ALLERGY&DestDOIRegistrantName=Dove+Medical+Press |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210915 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 142731773 |a Trinkmann, Frederik |m 142731773:Trinkmann, Frederik |d 910000 |d 950000 |d 950900 |d 60000 |d 61000 |e 910000PT142731773 |e 950000PT142731773 |e 950900PT142731773 |e 60000PT142731773 |e 61000PT142731773 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/60000/ |k 1/60000/61000/ |p 2 | ||
| 999 | |a KXP-PPN1770729860 |e 3978347857 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"13 July 2021"}],"physDesc":[{"extent":"9 S."}],"recId":"1770729860","id":{"eki":["1770729860"],"doi":["10.2147/JAA.S313572"]},"person":[{"display":"Abdo, Mustafa","family":"Abdo","role":"aut","given":"Mustafa"},{"given":"Frederik","role":"aut","family":"Trinkmann","display":"Trinkmann, Frederik"},{"given":"Anne-Marie","role":"aut","family":"Kirsten","display":"Kirsten, Anne-Marie"},{"display":"Biller, Heike","family":"Biller","role":"aut","given":"Heike"},{"family":"Pedersen","display":"Pedersen, Frauke","role":"aut","given":"Frauke"},{"family":"Waschki","display":"Waschki, Benjamin","given":"Benjamin","role":"aut"},{"given":"Erika","role":"aut","display":"Von Mutius, Erika","family":"Von Mutius"},{"given":"Matthias Volkmar","role":"aut","display":"Kopp, Matthias Volkmar","family":"Kopp"},{"display":"Hansen, Gesine","family":"Hansen","given":"Gesine","role":"aut"},{"role":"aut","given":"Klaus F.","display":"Rabe, Klaus F.","family":"Rabe"},{"display":"Bahmer, Thomas","family":"Bahmer","given":"Thomas","role":"aut"},{"role":"aut","given":"Henrik","display":"Watz, Henrik","family":"Watz"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Mustafa Abdo, Frederik Trinkmann, Anne-Marie Kirsten, Heike Biller, Frauke Pedersen, Benjamin Waschki, Erika Von Mutius, Matthias Volkmar Kopp, Gesine Hansen, Klaus F. Rabe, Thomas Bahmer, Henrik Watz, on behalf of the ALLIANCE study group"]},"language":["eng"],"title":[{"title_sort":"relevance of small airway dysfunction in asthma with nocturnal symptoms","title":"The relevance of small airway dysfunction in asthma with nocturnal symptoms"}],"note":["Gesehen am 15.09.2021"],"relHost":[{"id":{"issn":["1178-6965"],"zdb":["2494877-9"],"eki":["60030616X"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"publisher":"Dove Medical Press","dateIssuedKey":"2008","dateIssuedDisp":"2008-","publisherPlace":"Albany, Auckland"}],"disp":"The relevance of small airway dysfunction in asthma with nocturnal symptomsJournal of asthma and allergy","physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"part":{"year":"2021","pages":"897-905","volume":"14","text":"14(2021), Seite 897-905","extent":"9"},"pubHistory":["1.2008 -"],"title":[{"title_sort":"Journal of asthma and allergy","title":"Journal of asthma and allergy"}],"recId":"60030616X"}]} | ||
| SRT | |a ABDOMUSTAFRELEVANCEO1320 | ||