Physiological doses of calcium regulatory hormones do not normalize bone cells in uraemic rats
Low bone turnover despite normal parathyroid hormone (PTH) concentrations has been found in many patients with end-stage renal failure. Hyporesponsiveness to the calcaemic action is also a known feature of uraemia. Hyporesponsiveness of bone surface cells involved in bone modelling has not been demo...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1999
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| In: |
European journal of clinical investigation
Year: 1999, Jahrgang: 29, Heft: 6, Pages: 529-535 |
| ISSN: | 1365-2362 |
| DOI: | 10.1046/j.1365-2362.1999.00499.x |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1046/j.1365-2362.1999.00499.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2362.1999.00499.x 
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| Verfasserangaben: | A. Szabó, M.G. Freesmeyer, K. Abendroth, G. Stein, L. Rosivall, A. El-Shakmak and E. Ritz |
MARC
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| 245 | 1 | 0 | |a Physiological doses of calcium regulatory hormones do not normalize bone cells in uraemic rats |c A. Szabó, M.G. Freesmeyer, K. Abendroth, G. Stein, L. Rosivall, A. El-Shakmak and E. Ritz |
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| 500 | |a Gesehen am 15.09.2021 | ||
| 520 | |a Low bone turnover despite normal parathyroid hormone (PTH) concentrations has been found in many patients with end-stage renal failure. Hyporesponsiveness to the calcaemic action is also a known feature of uraemia. Hyporesponsiveness of bone surface cells involved in bone modelling has not been demonstrated to date. It was the purpose of this study using a rat model of moderate renal failure to investigate whether doses of PTH and calcitriol that reverse the effect of parathyroidectomy on calcaemia also normalize bone surface cell activity. | ||
| 650 | 4 | |a Calcitriol | |
| 650 | 4 | |a parathyroid hormone | |
| 650 | 4 | |a parathyroid hormone resistance | |
| 650 | 4 | |a secondary hyperparathyroidism | |
| 650 | 4 | |a uraemia | |
| 700 | 1 | |a Freesmeyer, M. G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Abendroth, K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stein, G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rosivall, L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a El-Shakmak, A. |e VerfasserIn |4 aut | |
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