Monocyte count as a prognostic biomarker in patients with idiopathic pulmonary fibrosis
Rationale: There is an urgent need for simple, cost-effective prognostic biomarkers for idiopathic pulmonary fibrosis (IPF); biomarkers that show potential include monocyte count. Objectives: We used pooled data from pirfenidone and IFN gamma-1b trials to explore the association between monocyte cou...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 12, 2021
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| In: |
American journal of respiratory and critical care medicine
Year: 2021, Jahrgang: 204, Heft: 1, Pages: 74-81 |
| ISSN: | 1535-4970 |
| DOI: | 10.1164/rccm.202003-0669OC |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1164/rccm.202003-0669OC Verlag, lizenzpflichtig, Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DOISource&SrcApp=WOS&KeyAID=10.1164%2Frccm.202003-0669oc&DestApp=DOI&SrcAppSID=C6YYap1tn4dp3Ya7FlH&SrcJTitle=AMERICAN+JOURNAL+OF+RESPIRATORY+AND+CRITICAL+CARE+MEDICINE&DestDOIRegistrantName=American+Thoracic+Society 
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| Verfasserangaben: | Michael Kreuter, Joyce S. Lee, Argyrios Tzouvelekis, Justin M. Oldham, Philip L. Molyneaux, Derek Weycker, Mark Atwood, Klaus-Uwe Kirchgaessler, and Toby M. Maher |
MARC
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| 245 | 1 | 0 | |a Monocyte count as a prognostic biomarker in patients with idiopathic pulmonary fibrosis |c Michael Kreuter, Joyce S. Lee, Argyrios Tzouvelekis, Justin M. Oldham, Philip L. Molyneaux, Derek Weycker, Mark Atwood, Klaus-Uwe Kirchgaessler, and Toby M. Maher |
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| 520 | |a Rationale: There is an urgent need for simple, cost-effective prognostic biomarkers for idiopathic pulmonary fibrosis (IPF); biomarkers that show potential include monocyte count. Objectives: We used pooled data from pirfenidone and IFN gamma-1b trials to explore the association between monocyte count and prognosis in patients with IPF. Methods: This retrospective pooled analysis included patients (active and placebo arms) from the following four phase III, randomized, placebo-controlled trials: ASCEND (NCT01366209), CAPACITY (NCT00287729 and NCT00287716), and INSPIRE (NCT00075998). Outcomes included IPF progression (>= 10% absolute decline in FVC% predicted,>= 50mdecline in 6-minute-walk distance, or death), all-cause hospitalization, and all-cause mortality over 1 year. The relationship between monocyte count (defined as time-dependent) and outcomes was assessed using bivariate and multivariable models. Measurements and Main Results: This analysis included 2,067 patients stratified by monocyte count (at baseline:,0.603109 cells/L [n = 1,609], 0.60 to <0.95x10(9) cells/L [n= 408], and >= 0.95x10(9) cells/L [n = 50]). In adjusted analyses, a higher proportion of patients with monocyte counts of 0.60 to,0.953109 cells/L or >0.953109 cells/L versus,0.603109 cells/L experienced IPF progression (P= 0.016 and P = 0.002, respectively), all-cause hospitalization (P= 0.030 and P = 0.003, respectively), and all-cause mortality (P= 0.005 and P, 0.001, respectively) over 1 year. Change inmonocyte count frombaseline was not associated with any of the outcomes over 1 year and did not appear to be affected by study treatment. Conclusions: In patients with IPF, elevated monocyte count was associated with increased risks of IPF progression, hospitalization, and mortality. Monocyte count may provide a simple and inexpensive prognostic biomarker in IPF. | ||
| 650 | 4 | |a biomarkers | |
| 650 | 4 | |a capacity | |
| 650 | 4 | |a clinical-course | |
| 650 | 4 | |a differentiation | |
| 650 | 4 | |a macrophages | |
| 650 | 4 | |a multicenter | |
| 650 | 4 | |a pirfenidone | |
| 650 | 4 | |a prediction | |
| 650 | 4 | |a prognosis | |
| 650 | 4 | |a pulmonary fibrosis | |
| 650 | 4 | |a serum | |
| 650 | 4 | |a survival | |
| 650 | 4 | |a validation | |
| 700 | 1 | |a Lee, Joyce S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tzouvelekis, Argyrios |e VerfasserIn |4 aut | |
| 700 | 1 | |a Oldham, Justin M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Molyneaux, Philip L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weycker, Derek |e VerfasserIn |4 aut | |
| 700 | 1 | |a Atwood, Mark |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kirchgaessler, Klaus-Uwe |e VerfasserIn |4 aut | |
| 700 | 1 | |a Maher, Toby M. |e VerfasserIn |4 aut | |
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