Integration of spatial PD-L1 expression with the tumor immune microenvironment outperforms standard PD-L1 scoring in outcome prediction of urothelial cancer patients
Background: Immune therapy has gained significant importance in managing urothelial cancer. The value of PD-L1 remains a matter of controversy, thus requiring an in-depth analysis of its biological and clinical relevance. Methods: A total of 193 tumors of muscle-invasive bladder cancer patients (MIB...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
12 May 2021
|
| In: |
Cancers
Year: 2021, Jahrgang: 13, Heft: 10, Pages: 1-15 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers13102327 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/cancers13102327 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6694/13/10/2327 
|
| Verfasserangaben: | Veronika Weyerer, Pamela L. Strissel, Reiner Strick, Danijel Sikic, Carol I. Geppert, Simone Bertz, Fabienne Lange, Helge Taubert, Sven Wach, Johannes Breyer, Christian Bolenz, Philipp Erben, Bernd J. Schmitz-Draeger, Bernd Wullich, Arndt Hartmann and Markus Eckstein |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1770842683 | ||
| 003 | DE-627 | ||
| 005 | 20220820044224.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210916s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/cancers13102327 |2 doi | |
| 035 | |a (DE-627)1770842683 | ||
| 035 | |a (DE-599)KXP1770842683 | ||
| 035 | |a (OCoLC)1341421317 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Weyerer, Veronika |e VerfasserIn |0 (DE-588)1202798284 |0 (DE-627)1687284652 |4 aut | |
| 245 | 1 | 0 | |a Integration of spatial PD-L1 expression with the tumor immune microenvironment outperforms standard PD-L1 scoring in outcome prediction of urothelial cancer patients |c Veronika Weyerer, Pamela L. Strissel, Reiner Strick, Danijel Sikic, Carol I. Geppert, Simone Bertz, Fabienne Lange, Helge Taubert, Sven Wach, Johannes Breyer, Christian Bolenz, Philipp Erben, Bernd J. Schmitz-Draeger, Bernd Wullich, Arndt Hartmann and Markus Eckstein |
| 264 | 1 | |c 12 May 2021 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 16.09.2021 | ||
| 520 | |a Background: Immune therapy has gained significant importance in managing urothelial cancer. The value of PD-L1 remains a matter of controversy, thus requiring an in-depth analysis of its biological and clinical relevance. Methods: A total of 193 tumors of muscle-invasive bladder cancer patients (MIBC) were assessed with four PD-L1 assays. PD-L1 scoring results were correlated with data from a comprehensive digital-spatial immune-profiling panel using descriptive statistics, hierarchical clustering and uni-/multivariable survival analyses. Results: PD-L1 scoring algorithms are heterogeneous (agreements from 63.1% to 87.7%), and stems from different constellations of immune and tumor cells (IC/TC). While Ventana IC5% algorithm identifies tumors with high inflammation and favorable baseline prognosis, CPS10 and the TCarea25%/ICarea25% algorithm identify tumors with TC and IC expression. Spatially organized immune phenotypes, which correlate either with high PD-L1 IC expression and favorable prognosis or constitutive PD-L1 TC expression and poor baseline prognosis, cannot be resolved properly by PD-L1 algorithms. PD-L1 negative tumors with relevant immune infiltration can be detected by sTILs scoring on HE slides and digital CD8+ scoring. Conclusions: Contemporary PD-L1 scoring algorithms are not sufficient to resolve spatially distributed MIBC immune phenotypes and their clinical implications. A more comprehensive view of immune phenotypes along with the integration of spatial PD-L1 expression on IC and TC is necessary in order to stratify patients for ICI. | ||
| 650 | 4 | |a bladder cancer | |
| 650 | 4 | |a immune phenotypes | |
| 650 | 4 | |a PD-1 | |
| 650 | 4 | |a PD-L1 | |
| 650 | 4 | |a TILs | |
| 650 | 4 | |a urothelial cancer | |
| 700 | 1 | |a Strissel, Pamela L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Strick, Reiner |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sikic, Danijel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Geppert, Carol I. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bertz, Simone |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lange, Fabienne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Taubert, Helge |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wach, Sven |e VerfasserIn |4 aut | |
| 700 | 1 | |a Breyer, Johannes |e VerfasserIn |0 (DE-588)1155510593 |0 (DE-627)1017777454 |0 (DE-576)501694145 |4 aut | |
| 700 | 1 | |a Bolenz, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Erben, Philipp |d 1973- |e VerfasserIn |0 (DE-588)128501014 |0 (DE-627)373920997 |0 (DE-576)297181661 |4 aut | |
| 700 | 1 | |a Schmitz-Draeger, Bernd J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wullich, Bernd |d 1960- |e VerfasserIn |0 (DE-588)110835794 |0 (DE-627)691096716 |0 (DE-576)302885749 |4 aut | |
| 700 | 1 | |a Hartmann, Arndt |e VerfasserIn |4 aut | |
| 700 | 1 | |a Eckstein, Markus |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancers |d Basel : MDPI, 2009 |g 13(2021), 10, Artikel-ID 2327, Seite 1-15 |h Online-Ressource |w (DE-627)614095670 |w (DE-600)2527080-1 |w (DE-576)313958548 |x 2072-6694 |7 nnas |a Integration of spatial PD-L1 expression with the tumor immune microenvironment outperforms standard PD-L1 scoring in outcome prediction of urothelial cancer patients |
| 773 | 1 | 8 | |g volume:13 |g year:2021 |g number:10 |g elocationid:2327 |g pages:1-15 |g extent:15 |a Integration of spatial PD-L1 expression with the tumor immune microenvironment outperforms standard PD-L1 scoring in outcome prediction of urothelial cancer patients |
| 856 | 4 | 0 | |u https://doi.org/10.3390/cancers13102327 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2072-6694/13/10/2327 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210916 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 128501014 |a Erben, Philipp |m 128501014:Erben, Philipp |d 60000 |d 63100 |e 60000PE128501014 |e 63100PE128501014 |k 0/60000/ |k 1/60000/63100/ |p 12 | ||
| 999 | |a KXP-PPN1770842683 |e 3978943913 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Weyerer","given":"Veronika","role":"aut","display":"Weyerer, Veronika"},{"given":"Pamela L.","role":"aut","display":"Strissel, Pamela L.","family":"Strissel"},{"display":"Strick, Reiner","role":"aut","given":"Reiner","family":"Strick"},{"family":"Sikic","display":"Sikic, Danijel","role":"aut","given":"Danijel"},{"family":"Geppert","display":"Geppert, Carol I.","role":"aut","given":"Carol I."},{"family":"Bertz","display":"Bertz, Simone","given":"Simone","role":"aut"},{"display":"Lange, Fabienne","given":"Fabienne","role":"aut","family":"Lange"},{"family":"Taubert","display":"Taubert, Helge","given":"Helge","role":"aut"},{"family":"Wach","given":"Sven","role":"aut","display":"Wach, Sven"},{"role":"aut","given":"Johannes","display":"Breyer, Johannes","family":"Breyer"},{"given":"Christian","role":"aut","display":"Bolenz, Christian","family":"Bolenz"},{"family":"Erben","role":"aut","given":"Philipp","display":"Erben, Philipp"},{"display":"Schmitz-Draeger, Bernd J.","role":"aut","given":"Bernd J.","family":"Schmitz-Draeger"},{"role":"aut","given":"Bernd","display":"Wullich, Bernd","family":"Wullich"},{"family":"Hartmann","display":"Hartmann, Arndt","given":"Arndt","role":"aut"},{"given":"Markus","role":"aut","display":"Eckstein, Markus","family":"Eckstein"}],"name":{"displayForm":["Veronika Weyerer, Pamela L. Strissel, Reiner Strick, Danijel Sikic, Carol I. Geppert, Simone Bertz, Fabienne Lange, Helge Taubert, Sven Wach, Johannes Breyer, Christian Bolenz, Philipp Erben, Bernd J. Schmitz-Draeger, Bernd Wullich, Arndt Hartmann and Markus Eckstein"]},"relHost":[{"pubHistory":["1.2009 -"],"title":[{"title":"Cancers","title_sort":"Cancers"}],"language":["eng"],"part":{"extent":"15","pages":"1-15","issue":"10","volume":"13","text":"13(2021), 10, Artikel-ID 2327, Seite 1-15","year":"2021"},"disp":"Integration of spatial PD-L1 expression with the tumor immune microenvironment outperforms standard PD-L1 scoring in outcome prediction of urothelial cancer patientsCancers","physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["614095670"],"issn":["2072-6694"],"zdb":["2527080-1"]},"note":["Gesehen am 27.05.2020"],"origin":[{"publisherPlace":"Basel","dateIssuedKey":"2009","publisher":"MDPI","dateIssuedDisp":"2009-"}],"recId":"614095670","type":{"bibl":"periodical","media":"Online-Ressource"},"name":{"displayForm":["Molecular Diversity Preservation International (MDPI)"]}}],"note":["Gesehen am 16.09.2021"],"physDesc":[{"extent":"15 S."}],"id":{"eki":["1770842683"],"doi":["10.3390/cancers13102327"]},"recId":"1770842683","origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"12 May 2021"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"title":[{"title":"Integration of spatial PD-L1 expression with the tumor immune microenvironment outperforms standard PD-L1 scoring in outcome prediction of urothelial cancer patients","title_sort":"Integration of spatial PD-L1 expression with the tumor immune microenvironment outperforms standard PD-L1 scoring in outcome prediction of urothelial cancer patients"}]} | ||
| SRT | |a WEYERERVERINTEGRATIO1220 | ||