Cover Image

RGS5 attenuates baseline activity of ERK1/2 and promotes growth arrest of vascular smooth muscle cells

The regulator of G-protein signaling 5 (RGS5) acts as an inhibitor of Gαq/11 and Gαi/o activity in vascular smooth muscle cells (VSMCs), which regulate arterial tone and blood pressure. While RGS5 has been described as a crucial determinant regulating the VSMC responses during various vascular remod...

Full description

Saved in:
Bibliographic Details
Main Authors: Demirel, Eda (Author) , Arnold, Caroline (Author) , Garg, Jaspal (Author) , Jäger, Marius Andreas (Author) , Sticht, Carsten (Author) , Li, Rui (Author) , Kuk, Hanna (Author) , Wettschureck, Nina (Author) , Hecker, Markus (Author) , Korff, Thomas (Author)
Format: Article (Journal)
Language:English
Published: 11 July 2021
In: Cells
Year: 2021, Volume: 10, Issue: 7, Pages: 1-20
ISSN:2073-4409
DOI:10.3390/cells10071748
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/cells10071748
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2073-4409/10/7/1748
Get full text
Author Notes:Eda Demirel, Caroline Arnold, Jaspal Garg, Marius Andreas Jäger, Carsten Sticht, Rui Li, Hanna Kuk, Nina Wettschureck, Markus Hecker and Thomas Korff

MARC

LEADER 00000caa a2200000 c 4500
001 1771721057
003 DE-627
005 20220820050349.0
007 cr uuu---uuuuu
008 210923s2021 xx |||||o 00| ||eng c
024 7 |a 10.3390/cells10071748  |2 doi 
035 |a (DE-627)1771721057 
035 |a (DE-599)KXP1771721057 
035 |a (OCoLC)1341421478 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Demirel, Eda  |e VerfasserIn  |0 (DE-588)1164995375  |0 (DE-627)1029205051  |0 (DE-576)510187692  |4 aut 
245 1 0 |a RGS5 attenuates baseline activity of ERK1/2 and promotes growth arrest of vascular smooth muscle cells  |c Eda Demirel, Caroline Arnold, Jaspal Garg, Marius Andreas Jäger, Carsten Sticht, Rui Li, Hanna Kuk, Nina Wettschureck, Markus Hecker and Thomas Korff 
264 1 |c 11 July 2021 
300 |a 20 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 23.09.2021 
520 |a The regulator of G-protein signaling 5 (RGS5) acts as an inhibitor of Gαq/11 and Gαi/o activity in vascular smooth muscle cells (VSMCs), which regulate arterial tone and blood pressure. While RGS5 has been described as a crucial determinant regulating the VSMC responses during various vascular remodeling processes, its regulatory features in resting VSMCs and its impact on their phenotype are still under debate and were subject of this study. While Rgs5 shows a variable expression in mouse arteries, neither global nor SMC-specific genetic ablation of Rgs5 affected the baseline blood pressure yet elevated the phosphorylation level of the MAP kinase ERK1/2. Comparable results were obtained with 3D cultured resting VSMCs. In contrast, overexpression of RGS5 in 2D-cultured proliferating VSMCs promoted their resting state as evidenced by microarray-based expression profiling and attenuated the activity of Akt- and MAP kinase-related signaling cascades. Moreover, RGS5 overexpression attenuated ERK1/2 phosphorylation, VSMC proliferation, and migration, which was mimicked by selectively inhibiting Gαi/o but not Gαq/11 activity. Collectively, the heterogeneous expression of Rgs5 suggests arterial blood vessel type-specific functions in mouse VSMCs. This comprises inhibition of acute agonist-induced Gαq/11/calcium release as well as the support of a resting VSMC phenotype with low ERK1/2 activity by suppressing the activity of Gαi/o. 
650 4 |a blood pressure 
650 4 |a ERK1/2 
650 4 |a G-protein signaling 
650 4 |a RGS proteins 
650 4 |a VSMC phenotype 
700 1 |a Arnold, Caroline  |e VerfasserIn  |0 (DE-588)1074276353  |0 (DE-627)831955406  |0 (DE-576)442346050  |4 aut 
700 1 |a Garg, Jaspal  |e VerfasserIn  |0 (DE-588)1136090185  |0 (DE-627)891232001  |0 (DE-576)490306845  |4 aut 
700 1 |a Jäger, Marius Andreas  |e VerfasserIn  |0 (DE-588)1206940816  |0 (DE-627)1693170205  |4 aut 
700 1 |a Sticht, Carsten  |d 1972-  |e VerfasserIn  |0 (DE-588)1020115718  |0 (DE-627)691110077  |0 (DE-576)250042177  |4 aut 
700 1 |a Li, Rui  |e VerfasserIn  |4 aut 
700 1 |a Kuk, Hanna  |e VerfasserIn  |0 (DE-588)1150443944  |0 (DE-627)1010762923  |0 (DE-576)497075784  |4 aut 
700 1 |a Wettschureck, Nina  |d 1971-  |e VerfasserIn  |0 (DE-588)120748630  |0 (DE-627)080865828  |0 (DE-576)182697207  |4 aut 
700 1 |a Hecker, Markus  |d 1960-  |e VerfasserIn  |0 (DE-588)1071693344  |0 (DE-627)826266037  |0 (DE-576)433260319  |4 aut 
700 1 |a Korff, Thomas  |e VerfasserIn  |0 (DE-588)1048734951  |0 (DE-627)781211824  |0 (DE-576)386952604  |4 aut 
773 0 8 |i Enthalten in  |t Cells  |d Basel : MDPI, 2012  |g 10(2021), 7, special issue, Artikel-ID 1748, Seite 1-20  |h Online-Ressource  |w (DE-627)718622081  |w (DE-600)2661518-6  |w (DE-576)365412112  |x 2073-4409  |7 nnas  |a RGS5 attenuates baseline activity of ERK1/2 and promotes growth arrest of vascular smooth muscle cells 
773 1 8 |g volume:10  |g year:2021  |g number:7  |g supplement:special issue  |g elocationid:1748  |g pages:1-20  |g extent:20  |a RGS5 attenuates baseline activity of ERK1/2 and promotes growth arrest of vascular smooth muscle cells 
856 4 0 |u https://doi.org/10.3390/cells10071748  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.mdpi.com/2073-4409/10/7/1748  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20210923 
993 |a Article 
994 |a 2021 
998 |g 1048734951  |a Korff, Thomas  |m 1048734951:Korff, Thomas  |d 50000  |d 53200  |d 50000  |e 50000PK1048734951  |e 53200PK1048734951  |e 50000PK1048734951  |k 0/50000/  |k 1/50000/53200/  |k 0/50000/  |p 10  |y j 
998 |g 1071693344  |a Hecker, Markus  |m 1071693344:Hecker, Markus  |d 50000  |d 53200  |e 50000PH1071693344  |e 53200PH1071693344  |k 0/50000/  |k 1/50000/53200/  |p 9 
998 |g 120748630  |a Wettschureck, Nina  |m 120748630:Wettschureck, Nina  |p 8 
998 |g 1150443944  |a Kuk, Hanna  |m 1150443944:Kuk, Hanna  |p 7 
998 |g 1020115718  |a Sticht, Carsten  |m 1020115718:Sticht, Carsten  |d 60000  |d 999811  |e 60000PS1020115718  |e 999811PS1020115718  |k 0/60000/  |k 1/60000/999811/  |p 5 
998 |g 1206940816  |a Jäger, Marius Andreas  |m 1206940816:Jäger, Marius Andreas  |p 4 
998 |g 1136090185  |a Garg, Jaspal  |m 1136090185:Garg, Jaspal  |d 50000  |d 53200  |e 50000PG1136090185  |e 53200PG1136090185  |k 0/50000/  |k 1/50000/53200/  |p 3 
998 |g 1074276353  |a Arnold, Caroline  |m 1074276353:Arnold, Caroline  |p 2 
998 |g 1164995375  |a Demirel, Eda  |m 1164995375:Demirel, Eda  |d 700000  |d 711000  |e 700000PD1164995375  |e 711000PD1164995375  |k 0/700000/  |k 1/700000/711000/  |p 1  |x j 
999 |a KXP-PPN1771721057  |e 398072381X 
BIB |a Y 
SER |a journal 
JSO |a {"name":{"displayForm":["Eda Demirel, Caroline Arnold, Jaspal Garg, Marius Andreas Jäger, Carsten Sticht, Rui Li, Hanna Kuk, Nina Wettschureck, Markus Hecker and Thomas Korff"]},"note":["Gesehen am 23.09.2021"],"language":["eng"],"title":[{"title_sort":"RGS5 attenuates baseline activity of ERK1/2 and promotes growth arrest of vascular smooth muscle cells","title":"RGS5 attenuates baseline activity of ERK1/2 and promotes growth arrest of vascular smooth muscle cells"}],"physDesc":[{"extent":"20 S."}],"relHost":[{"note":["Gesehen am 09.05.12"],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"title":[{"subtitle":"open access journal","title":"Cells","title_sort":"Cells"}],"origin":[{"publisher":"MDPI","publisherPlace":"Basel","dateIssuedKey":"2012","dateIssuedDisp":"2012-"}],"id":{"zdb":["2661518-6"],"eki":["718622081"],"issn":["2073-4409"]},"disp":"RGS5 attenuates baseline activity of ERK1/2 and promotes growth arrest of vascular smooth muscle cellsCells","part":{"volume":"10","pages":"1-20","year":"2021","extent":"20","issue":"7","text":"10(2021), 7, special issue, Artikel-ID 1748, Seite 1-20"},"pubHistory":["1.2012 -"],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"718622081"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"given":"Eda","family":"Demirel","display":"Demirel, Eda","role":"aut"},{"given":"Caroline","family":"Arnold","display":"Arnold, Caroline","role":"aut"},{"given":"Jaspal","role":"aut","family":"Garg","display":"Garg, Jaspal"},{"given":"Marius Andreas","family":"Jäger","display":"Jäger, Marius Andreas","role":"aut"},{"role":"aut","display":"Sticht, Carsten","family":"Sticht","given":"Carsten"},{"role":"aut","family":"Li","display":"Li, Rui","given":"Rui"},{"given":"Hanna","display":"Kuk, Hanna","family":"Kuk","role":"aut"},{"family":"Wettschureck","display":"Wettschureck, Nina","role":"aut","given":"Nina"},{"given":"Markus","family":"Hecker","display":"Hecker, Markus","role":"aut"},{"given":"Thomas","role":"aut","display":"Korff, Thomas","family":"Korff"}],"id":{"doi":["10.3390/cells10071748"],"eki":["1771721057"]},"recId":"1771721057","origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"11 July 2021"}]} 
SRT |a DEMIRELEDARGS5ATTENU1120 

Similar Items