Severe pneumonia in neonates associated with Legionella pneumophila: case report and review of the literature

The causative agent of legionellosis is the Gram-negative intracellular bacteria Legionella spp. Its clinical presentation varies from a mild febrile illness called Pontiac fever to the severe and possible fatal pneumonia, Legionnaires' disease. Immunocompromised patients, in particular, are af...

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Main Authors: Perez Ortiz, Alba (Author) , Hahn, Camilla (Author) , Schaible, Thomas (Author) , Rafat, Neysan (Author) , Lange, Bettina (Author)
Format: Article (Journal)
Language:English
Published: 15 August 2021
In: Pathogens
Year: 2021, Volume: 10, Issue: 8, Pages: 1-11
ISSN:2076-0817
DOI:10.3390/pathogens10081031
Online Access:Verlag, Volltext: https://doi.org/10.3390/pathogens10081031
Verlag: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DOISource&SrcApp=WOS&KeyAID=10.3390%2Fpathogens10081031&DestApp=DOI&SrcAppSID=D5uIu7JVch6JSwjtsIG&SrcJTitle=PATHOGENS&DestDOIRegistrantName=MDPI+AG
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Author Notes:Alba Perez Ortiz, Camilla Hahn, Thomas Schaible, Neysan Rafat and Bettina Lange

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520 |a The causative agent of legionellosis is the Gram-negative intracellular bacteria Legionella spp. Its clinical presentation varies from a mild febrile illness called Pontiac fever to the severe and possible fatal pneumonia, Legionnaires' disease. Immunocompromised patients, in particular, are affected. Only a small number of infected neonates are described in the literature. Most of them have been associated with water birth or the use of air humidifiers. In the last five years, a growing number of cases have been reported in Germany by the national institute of disease surveillance and prevention (Robert-Koch Institute). Here, we describe a fatal case report of pulmonary legionellosis with acute respiratory distress syndrome (ARDS), sepsis, associated cutaneous manifestation, and extracorporeal membrane oxygenation in a full-term neonate. Moreover, we present a review of the literature discussing the epidemiology, risk factors, clinical features, diagnostics, treatment options, and prevention for this rare condition in neonates. 
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