Severe pneumonia in neonates associated with Legionella pneumophila: case report and review of the literature
The causative agent of legionellosis is the Gram-negative intracellular bacteria Legionella spp. Its clinical presentation varies from a mild febrile illness called Pontiac fever to the severe and possible fatal pneumonia, Legionnaires' disease. Immunocompromised patients, in particular, are af...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 August 2021
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| In: |
Pathogens
Year: 2021, Volume: 10, Issue: 8, Pages: 1-11 |
| ISSN: | 2076-0817 |
| DOI: | 10.3390/pathogens10081031 |
| Online Access: | Verlag, Volltext: https://doi.org/10.3390/pathogens10081031 Verlag: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DOISource&SrcApp=WOS&KeyAID=10.3390%2Fpathogens10081031&DestApp=DOI&SrcAppSID=D5uIu7JVch6JSwjtsIG&SrcJTitle=PATHOGENS&DestDOIRegistrantName=MDPI+AG 
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| Author Notes: | Alba Perez Ortiz, Camilla Hahn, Thomas Schaible, Neysan Rafat and Bettina Lange |
| Summary: | The causative agent of legionellosis is the Gram-negative intracellular bacteria Legionella spp. Its clinical presentation varies from a mild febrile illness called Pontiac fever to the severe and possible fatal pneumonia, Legionnaires' disease. Immunocompromised patients, in particular, are affected. Only a small number of infected neonates are described in the literature. Most of them have been associated with water birth or the use of air humidifiers. In the last five years, a growing number of cases have been reported in Germany by the national institute of disease surveillance and prevention (Robert-Koch Institute). Here, we describe a fatal case report of pulmonary legionellosis with acute respiratory distress syndrome (ARDS), sepsis, associated cutaneous manifestation, and extracorporeal membrane oxygenation in a full-term neonate. Moreover, we present a review of the literature discussing the epidemiology, risk factors, clinical features, diagnostics, treatment options, and prevention for this rare condition in neonates. |
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| Item Description: | Gesehen am 27.09.2021 |
| Physical Description: | Online Resource |
| ISSN: | 2076-0817 |
| DOI: | 10.3390/pathogens10081031 |