Hippocampal NMDA receptors are important for behavioural inhibition but not for encoding associative spatial memories
The idea that an NMDA receptor (NMDAR)-dependent long-term potentiation-like process in the hippocampus is the neural substrate for associative spatial learning and memory has proved to be extremely popular and influential. However, we recently reported that mice lacking NMDARs in dentate gyrus and...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
05 January 2014
|
| In: |
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Year: 2014, Volume: 369, Pages: 1-9 |
| ISSN: | 0080-4622 |
| DOI: | 10.1098/rstb.2013.0149 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1098/rstb.2013.0149 Verlag, lizenzpflichtig, Volltext: https://royalsocietypublishing.org/doi/10.1098/rstb.2013.0149 
|
| Author Notes: | A.M. Taylor, T. Bus, R. Sprengel, P.H. Seeburg, J.N.P. Rawlins and D.M. Bannerman |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1771933607 | ||
| 003 | DE-627 | ||
| 005 | 20220820051348.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210928s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1098/rstb.2013.0149 |2 doi | |
| 035 | |a (DE-627)1771933607 | ||
| 035 | |a (DE-599)KXP1771933607 | ||
| 035 | |a (OCoLC)1341421286 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Taylor, A. M. |d 19XX- |e VerfasserIn |0 (DE-588)1196641226 |0 (DE-627)1678475416 |4 aut | |
| 245 | 1 | 0 | |a Hippocampal NMDA receptors are important for behavioural inhibition but not for encoding associative spatial memories |c A.M. Taylor, T. Bus, R. Sprengel, P.H. Seeburg, J.N.P. Rawlins and D.M. Bannerman |
| 264 | 1 | |c 05 January 2014 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.09.2021 | ||
| 520 | |a The idea that an NMDA receptor (NMDAR)-dependent long-term potentiation-like process in the hippocampus is the neural substrate for associative spatial learning and memory has proved to be extremely popular and influential. However, we recently reported that mice lacking NMDARs in dentate gyrus and CA1 hippocampal subfields (GluN1ΔDGCA1 mice) acquired the open field, spatial reference memory watermaze task as well as controls, a result that directly challenges this view. Here, we show that GluN1ΔDGCA1 mice were not impaired during acquisition of a spatial discrimination watermaze task, during which mice had to choose between two visually identical beacons, based on extramaze spatial cues, when all trials started at locations equidistant between the two beacons. They were subsequently impaired on test trials starting from close to the decoy beacon, conducted post-acquisition. GluN1ΔDGCA1 mice were also impaired during reversal of this spatial discrimination. Thus, contrary to the widely held belief, hippocampal NMDARs are not required for encoding associative, long-term spatial memories. Instead, hippocampal NMDARs, particularly in CA1, act as part of a comparator system to detect and resolve conflicts arising when two competing, behavioural response options are evoked concurrently, through activation of a behavioural inhibition system. These results have important implications for current theories of hippocampal function. | ||
| 650 | 4 | |a hippocampus | |
| 650 | 4 | |a long-term potentiation | |
| 650 | 4 | |a NMDAR | |
| 650 | 4 | |a spatial learning | |
| 650 | 4 | |a synaptic plasticity | |
| 650 | 4 | |a watermaze | |
| 700 | 1 | |a Bus, Thorsten |e VerfasserIn |0 (DE-588)140932798 |0 (DE-627)623689138 |0 (DE-576)321026152 |4 aut | |
| 700 | 1 | |a Sprengel, Rolf |d 1955- |e VerfasserIn |0 (DE-588)1060395665 |0 (DE-627)799661228 |0 (DE-576)163694230 |4 aut | |
| 700 | 1 | |a Seeburg, Peter H. |d 1944-2016 |e VerfasserIn |0 (DE-588)11802454X |0 (DE-627)694605883 |0 (DE-576)291673767 |4 aut | |
| 700 | 1 | |a Rawlins, J. N. P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bannerman, D. M. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a Royal Society (London) |t Philosophical transactions of the Royal Society of London. Series B, Biological sciences |d London : [Verlag nicht ermittelbar], 1888 |g 369(2014), Artikel-ID 20130149, Seite 1-9 |h Online-Ressource |w (DE-627)394570294 |w (DE-600)2161425-8 |w (DE-576)281258546 |x 0080-4622 |7 nnas |
| 773 | 1 | 8 | |g volume:369 |g year:2014 |g elocationid:20130149 |g pages:1-9 |g extent:9 |a Hippocampal NMDA receptors are important for behavioural inhibition but not for encoding associative spatial memories |
| 856 | 4 | 0 | |u https://doi.org/10.1098/rstb.2013.0149 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://royalsocietypublishing.org/doi/10.1098/rstb.2013.0149 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210928 | ||
| 993 | |a Article | ||
| 994 | |a 2014 | ||
| 998 | |g 11802454X |a Seeburg, Peter H. |m 11802454X:Seeburg, Peter H. |d 50000 |e 50000PS11802454X |k 0/50000/ |p 4 | ||
| 998 | |g 1060395665 |a Sprengel, Rolf |m 1060395665:Sprengel, Rolf |p 3 | ||
| 998 | |g 140932798 |a Bus, Thorsten |m 140932798:Bus, Thorsten |p 2 | ||
| 999 | |a KXP-PPN1771933607 |e 3981722035 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["A.M. Taylor, T. Bus, R. Sprengel, P.H. Seeburg, J.N.P. Rawlins and D.M. Bannerman"]},"id":{"eki":["1771933607"],"doi":["10.1098/rstb.2013.0149"]},"origin":[{"dateIssuedDisp":"05 January 2014","dateIssuedKey":"2014"}],"relHost":[{"title":[{"partname":"Biological sciences","title":"Philosophical transactions of the Royal Society of London","title_sort":"Philosophical transactions of the Royal Society of London"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Royal Society (London)Philosophical transactions of the Royal Society of London. Series B, Biological sciences","note":["Gesehen am 19.08.2021"],"recId":"394570294","language":["eng"],"corporate":[{"display":"Royal Society","roleDisplay":"VerfasserIn","role":"aut"}],"pubHistory":["178.1888 - 222.1933 nachgewiesen"],"part":{"year":"2014","pages":"1-9","text":"369(2014), Artikel-ID 20130149, Seite 1-9","volume":"369","extent":"9"},"titleAlt":[{"title":"Philosophical transactions of the Royal Society of London / B"}],"origin":[{"publisherPlace":"London","publisher":"[Verlag nicht ermittelbar]","dateIssuedKey":"1888","dateIssuedDisp":"1888-"}],"id":{"zdb":["2161425-8"],"eki":["394570294"],"issn":["0080-4622"]},"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"9 S."}],"person":[{"display":"Taylor, A. M.","roleDisplay":"VerfasserIn","role":"aut","family":"Taylor","given":"A. M."},{"family":"Bus","given":"Thorsten","display":"Bus, Thorsten","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Sprengel, Rolf","roleDisplay":"VerfasserIn","role":"aut","family":"Sprengel","given":"Rolf"},{"display":"Seeburg, Peter H.","roleDisplay":"VerfasserIn","role":"aut","family":"Seeburg","given":"Peter H."},{"given":"J. N. P.","family":"Rawlins","role":"aut","roleDisplay":"VerfasserIn","display":"Rawlins, J. N. P."},{"given":"D. M.","family":"Bannerman","role":"aut","roleDisplay":"VerfasserIn","display":"Bannerman, D. M."}],"title":[{"title":"Hippocampal NMDA receptors are important for behavioural inhibition but not for encoding associative spatial memories","title_sort":"Hippocampal NMDA receptors are important for behavioural inhibition but not for encoding associative spatial memories"}],"recId":"1771933607","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 28.09.2021"]} | ||
| SRT | |a TAYLORAMBUHIPPOCAMPA0520 | ||