Tetrasubstituted 1,3-enynes by gold-catalyzed direct C(sp2)-H alkynylation of acceptor-substituted enamines
A gold-catalyzed synthesis of tetrasubstituted 1,3-enynes from hypervalent iodine(III) reagents and activated alkenes is reported. This reaction involves an in situ formed alkynyl Au(III) species and a subsequent direct C(sp2)-H functionalization of alkenes, offering 26 enynes in 62-92% yield with e...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 9, 2021
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| In: |
Organic letters
Year: 2021, Volume: 23, Issue: 12, Pages: 4764-4768 |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/acs.orglett.1c01486 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/acs.orglett.1c01486 Verlag, lizenzpflichtig, Volltext: https://pubs.acs.org/doi/10.1021/acs.orglett.1c01486 
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| Author Notes: | Chunyu Han, Xianhai Tian, Huili Zhang, Frank Rominger, and A. Stephen K. Hashmi |
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| 520 | |a A gold-catalyzed synthesis of tetrasubstituted 1,3-enynes from hypervalent iodine(III) reagents and activated alkenes is reported. This reaction involves an in situ formed alkynyl Au(III) species and a subsequent direct C(sp2)-H functionalization of alkenes, offering 26 enynes in 62-92% yield with excellent functional group tolerance. | ||
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