Cover Image

Tetrasubstituted 1,3-enynes by gold-catalyzed direct C(sp2)-H alkynylation of acceptor-substituted enamines

A gold-catalyzed synthesis of tetrasubstituted 1,3-enynes from hypervalent iodine(III) reagents and activated alkenes is reported. This reaction involves an in situ formed alkynyl Au(III) species and a subsequent direct C(sp2)-H functionalization of alkenes, offering 26 enynes in 62-92% yield with e...

Full description

Saved in:
Bibliographic Details
Main Authors: Han, Chunyu (Author) , Tian, Xianhai (Author) , Zhang, Huili (Author) , Rominger, Frank (Author) , Hashmi, A. Stephen K. (Author)
Format: Article (Journal)
Language:English
Published: June 9, 2021
In: Organic letters
Year: 2021, Volume: 23, Issue: 12, Pages: 4764-4768
ISSN:1523-7052
DOI:10.1021/acs.orglett.1c01486
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/acs.orglett.1c01486
Verlag, lizenzpflichtig, Volltext: https://pubs.acs.org/doi/10.1021/acs.orglett.1c01486
Get full text
Author Notes:Chunyu Han, Xianhai Tian, Huili Zhang, Frank Rominger, and A. Stephen K. Hashmi
Description
Summary:A gold-catalyzed synthesis of tetrasubstituted 1,3-enynes from hypervalent iodine(III) reagents and activated alkenes is reported. This reaction involves an in situ formed alkynyl Au(III) species and a subsequent direct C(sp2)-H functionalization of alkenes, offering 26 enynes in 62-92% yield with excellent functional group tolerance.
Item Description:Im Text ist "2" hochgestellt
Gesehen am 01.10.2021
Physical Description:Online Resource
ISSN:1523-7052
DOI:10.1021/acs.orglett.1c01486

Similar Items