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Subclinical cardiac impairment relates to traditional pulmonary function test parameters and lung volume as derived from whole-body MRI in a population-based cohort study

To evaluate the relationship of cardiac function, including time-volume-curves, with lung volumes derived from pulmonary function tests (PFT) and MRI in subjects without cardiovascular diseases. 216 subjects underwent whole-body MRI and spirometry as part of the KORA-FF4 cohort study. Lung volumes d...

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Main Authors: Krüchten, Ricarda von (Author) , Lorbeer, Roberto (Author) , Schuppert, Christopher (Author) , Storz, Corinna (Author) , Mujaj, Blerim (Author) , Schulz, Holger (Author) , Kauczor, Hans-Ulrich (Author) , Peters, Annette (Author) , Bamberg, Fabian (Author) , Karrasch, Stefan (Author) , Schlett, Christopher L. (Author)
Format: Article (Journal)
Language:English
Published: 09 August 2021
In: Scientific reports
Year: 2021, Volume: 11, Pages: 1-9
ISSN:2045-2322
DOI:10.1038/s41598-021-95655-7
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41598-021-95655-7
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41598-021-95655-7
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Author Notes:Ricarda von Krüchten, Roberto Lorbeer, Christopher Schuppert, Corinna Storz, Blerim Mujaj, Holger Schulz, Hans-Ulrich Kauczor, Annette Peters, Fabian Bamberg, Stefan Karrasch & Christopher L. Schlett
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Summary:To evaluate the relationship of cardiac function, including time-volume-curves, with lung volumes derived from pulmonary function tests (PFT) and MRI in subjects without cardiovascular diseases. 216 subjects underwent whole-body MRI and spirometry as part of the KORA-FF4 cohort study. Lung volumes derived semi-automatically using an in-house algorithm. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and residual volume were measured. Cardiac parameters derived from Cine-SSFP-sequence using cvi42, while left ventricle (LV) time-volume-curves were evaluated using pyHeart. Linear regression analyses assessed the relationships of cardiac parameters with PFT and MRI-based lung volumes. Mean age was 56.3 ± 9.2 years (57% males). LV and right ventricular (RV) end-diastolic-, end-systolic-, stroke volume, LV peak ejection- and early/late diastolic filling rate were associated with FEV1, FVC, and residual volume (excluding late diastolic filling rate with FEV1, LV end-systolic/stroke volume and RV end-diastolic/end-systolic volumes with residual volume). In contrast, LV end-diastolic volume (ß = − 0.14, p = 0.01), early diastolic filling rate (ß = − 0.11, p = 0.04), and LV/RV stroke volume (ß = − 0.14, p = 0.01; ß = − 0.11, p = 0.01) were inversely associated with MRI-based lung volume. Subclinical cardiac impairment was associated with reduced FEV1, FVC, and residual volume. Cardiac parameters decreased with increasing MRI-based lung volume contrasting the results of PFT.
Item Description:Gesehen am 02.10.2021
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-021-95655-7

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