Parathyroidectomy, elevated depression scores, and suicidal ideation in patients with primary hyperparathyroidism: results of a prospective multicenter study
To assess anxiety and depression symptoms, suicidal ideation, and health-related quality of life (HRQOL) in a large series of consecutive patients with primary hyperparathyroidism (pHPT) before and after parathyroidectomy.This prospective multicenter study investigated preoperative and postoperative...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2013
|
| In: |
JAMA surgery
Year: 2013, Volume: 148, Issue: 2, Pages: 109-115 |
| ISSN: | 2168-6262 |
| DOI: | 10.1001/2013.jamasurg.316 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1001/2013.jamasurg.316
|
| Author Notes: | Theresia Weber, Julia Eberle, Ursula Messelhäuser, Leif Schiffmann, Christoph Nies, Jochen Schabram, Andreas Zielke, Katharina Holzer, Edit Rottler, Doris Henne-Bruns, Monika Keller, Jörn von Wietersheim |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1772272957 | ||
| 003 | DE-627 | ||
| 005 | 20240414193410.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 211004s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1001/2013.jamasurg.316 |2 doi | |
| 035 | |a (DE-627)1772272957 | ||
| 035 | |a (DE-599)KXP1772272957 | ||
| 035 | |a (OCoLC)1341421599 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Weber, Theresia |e VerfasserIn |0 (DE-588)1077080751 |0 (DE-627)835994279 |0 (DE-576)166381209 |4 aut | |
| 245 | 1 | 0 | |a Parathyroidectomy, elevated depression scores, and suicidal ideation in patients with primary hyperparathyroidism |b results of a prospective multicenter study |c Theresia Weber, Julia Eberle, Ursula Messelhäuser, Leif Schiffmann, Christoph Nies, Jochen Schabram, Andreas Zielke, Katharina Holzer, Edit Rottler, Doris Henne-Bruns, Monika Keller, Jörn von Wietersheim |
| 264 | 1 | |c 2013 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online October 15, 2012 | ||
| 500 | |a Gesehen am 04.10.2021 | ||
| 520 | |a To assess anxiety and depression symptoms, suicidal ideation, and health-related quality of life (HRQOL) in a large series of consecutive patients with primary hyperparathyroidism (pHPT) before and after parathyroidectomy.This prospective multicenter study investigated preoperative and postoperative depression, anxiety, suicidal ideation, and HRQOL in patients with pHPT and compared these variables with a control group with nontoxic thyroid nodules.The study included 194 patients with pHPT and 186 control subjects.Depression was evaluated with the Hospital Anxiety and Depression Scale (HADS) and the Patient Health Questionnaire-9, which also assessed suicidal ideation. Anxiety was evaluated with the HADS. Health-related quality of life was measured with the 36-Item Short Form survey.Parathyroidectomy achieved a 98% cure rate. Preoperatively, severe depression (HADS score ≥11) was seen in 20% of the pHPT group and 9% of the control group. The Patient Health Questionnaire-9 detected moderate to severe depression in 17% of the patients with pHPT and 7% of the control subjects. Patients with pHPT had higher HADS anxiety scores (mean, 7.7) than control subjects (P < .01) or the German normative sample (P < .001). Compared with control subjects, patients with pHPT had significantly lower 36-Item Short Form survey preoperative physical and mental health summary scores (42.7 vs 49.5 and 41.2 vs 46.8, respectively; P = .001 for both comparisons). At 12 months follow-up, depression and anxiety decreased significantly in patients with pHPT; the prevalence of suicidal ideation was more than halved from the baseline (10.7% vs 22%; P = .008). Both physical and mental health scores (45.7 and 47.7, respectively) improved in patients with pHPT (P < .001 each) but not in control subjects.Depression, anxiety, and decreased HRQOL appear to be related to pHPT. Successful parathyroidectomy seems to reduce psychopathologic symptoms and improve HRQOL in this setting. | ||
| 700 | 1 | |a Eberle, Julia |d 1986- |e VerfasserIn |0 (DE-588)1076829376 |0 (DE-627)835367126 |0 (DE-576)445634030 |4 aut | |
| 700 | 1 | |a Messelhäuser, Ursula |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schiffmann, Leif |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nies, Christoph |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schabram, Jochen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zielke, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Holzer, Katharina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rottler, Edit |e VerfasserIn |4 aut | |
| 700 | 1 | |a Henne-Bruns, Doris |d 1954- |e VerfasserIn |0 (DE-588)133140024 |0 (DE-627)537501649 |0 (DE-576)299649385 |4 aut | |
| 700 | 1 | |a Keller, Monika |e VerfasserIn |0 (DE-588)1067877975 |0 (DE-627)819322253 |0 (DE-576)427031575 |4 aut | |
| 700 | 1 | |a Wietersheim, Jörn von |d 1956- |e VerfasserIn |0 (DE-588)121493040 |0 (DE-627)081343450 |0 (DE-576)292738382 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t JAMA surgery |d Chicago, Ill. : American Medical Association, 2013 |g 148(2013), 2, Seite 109-115 |h Online-Ressource |w (DE-627)736004823 |w (DE-600)2701844-1 |w (DE-576)378725858 |x 2168-6262 |7 nnas |a Parathyroidectomy, elevated depression scores, and suicidal ideation in patients with primary hyperparathyroidism results of a prospective multicenter study |
| 773 | 1 | 8 | |g volume:148 |g year:2013 |g number:2 |g pages:109-115 |g extent:7 |a Parathyroidectomy, elevated depression scores, and suicidal ideation in patients with primary hyperparathyroidism results of a prospective multicenter study |
| 856 | 4 | 0 | |u https://doi.org/10.1001/2013.jamasurg.316 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20211004 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1067877975 |a Keller, Monika |m 1067877975:Keller, Monika |d 910000 |d 910600 |d 50000 |e 910000PK1067877975 |e 910600PK1067877975 |e 50000PK1067877975 |k 0/910000/ |k 1/910000/910600/ |k 0/50000/ |p 11 | ||
| 999 | |a KXP-PPN1772272957 |e 3983534481 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"part":{"year":"2013","text":"148(2013), 2, Seite 109-115","volume":"148","issue":"2","pages":"109-115","extent":"7"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"JAMA surgery","title":"JAMA surgery"}],"language":["eng"],"id":{"zdb":["2701844-1"],"eki":["736004823"],"issn":["2168-6262"]},"pubHistory":["148.2013 -"],"note":["Gesehen am 12.10.2017"],"corporate":[{"role":"isb","display":"American Medical Association","roleDisplay":"Herausgebendes Organ"}],"disp":"Parathyroidectomy, elevated depression scores, and suicidal ideation in patients with primary hyperparathyroidism results of a prospective multicenter studyJAMA surgery","recId":"736004823","type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2013","publisherPlace":"Chicago, Ill.","dateIssuedDisp":"2013-","publisher":"American Medical Association"}]}],"name":{"displayForm":["Theresia Weber, Julia Eberle, Ursula Messelhäuser, Leif Schiffmann, Christoph Nies, Jochen Schabram, Andreas Zielke, Katharina Holzer, Edit Rottler, Doris Henne-Bruns, Monika Keller, Jörn von Wietersheim"]},"note":["Published online October 15, 2012","Gesehen am 04.10.2021"],"language":["eng"],"id":{"eki":["1772272957"],"doi":["10.1001/2013.jamasurg.316"]},"title":[{"title_sort":"Parathyroidectomy, elevated depression scores, and suicidal ideation in patients with primary hyperparathyroidism","subtitle":"results of a prospective multicenter study","title":"Parathyroidectomy, elevated depression scores, and suicidal ideation in patients with primary hyperparathyroidism"}],"physDesc":[{"extent":"7 S."}],"person":[{"family":"Weber","given":"Theresia","roleDisplay":"VerfasserIn","display":"Weber, Theresia","role":"aut"},{"family":"Eberle","given":"Julia","roleDisplay":"VerfasserIn","display":"Eberle, Julia","role":"aut"},{"roleDisplay":"VerfasserIn","given":"Ursula","family":"Messelhäuser","role":"aut","display":"Messelhäuser, Ursula"},{"family":"Schiffmann","given":"Leif","roleDisplay":"VerfasserIn","display":"Schiffmann, Leif","role":"aut"},{"role":"aut","display":"Nies, Christoph","given":"Christoph","roleDisplay":"VerfasserIn","family":"Nies"},{"display":"Schabram, Jochen","role":"aut","family":"Schabram","roleDisplay":"VerfasserIn","given":"Jochen"},{"role":"aut","display":"Zielke, Andreas","roleDisplay":"VerfasserIn","given":"Andreas","family":"Zielke"},{"given":"Katharina","roleDisplay":"VerfasserIn","family":"Holzer","role":"aut","display":"Holzer, Katharina"},{"display":"Rottler, Edit","role":"aut","family":"Rottler","given":"Edit","roleDisplay":"VerfasserIn"},{"display":"Henne-Bruns, Doris","role":"aut","family":"Henne-Bruns","roleDisplay":"VerfasserIn","given":"Doris"},{"given":"Monika","roleDisplay":"VerfasserIn","family":"Keller","role":"aut","display":"Keller, Monika"},{"roleDisplay":"VerfasserIn","given":"Jörn von","family":"Wietersheim","role":"aut","display":"Wietersheim, Jörn von"}],"origin":[{"dateIssuedDisp":"2013","dateIssuedKey":"2013"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1772272957"} | ||
| SRT | |a WEBERTHEREPARATHYROI2013 | ||