A multi-target caffeine derived rhodium(I) N-heterocyclic carbene complex: evaluation of the mechanism of action
A rhodium(I) and a ruthenium(II) complex with a caffeine derived N-heterocyclic carbene (NHC) ligand were biologically investigated as organometallic conjugates consisting of a metal center and a naturally occurring moiety. While the ruthenium(II) complex was largely inactive, the rhodium(I) NHC com...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
08 Jun 2016
|
| In: |
Dalton transactions
Year: 2016, Volume: 45, Issue: 33, Pages: 13161-13168 |
| ISSN: | 1477-9234 |
| DOI: | 10.1039/C6DT02025A |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/C6DT02025A Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2016/dt/c6dt02025a 
|
| Author Notes: | Jing-Jing Zhang, Julienne K. Muenzner, Mohamed A. Abu el Maaty, Bianka Karge, Rainer Schobert, Stefan Wölfl and Ingo Ott |
| Summary: | A rhodium(I) and a ruthenium(II) complex with a caffeine derived N-heterocyclic carbene (NHC) ligand were biologically investigated as organometallic conjugates consisting of a metal center and a naturally occurring moiety. While the ruthenium(II) complex was largely inactive, the rhodium(I) NHC complex displayed selective cytotoxicity and significant anti-metastatic and in vivo anti-vascular activities and acted as both a mammalian and an E. coli thioredoxin reductase inhibitor. In HCT-116 cells it increased the reactive oxygen species level, leading to DNA damage, and it induced cell cycle arrest, decreased the mitochondrial membrane potential, and triggered apoptosis. This rhodium(I) NHC derivative thus represents a multi-target compound with promising anti-cancer potential. |
|---|---|
| Item Description: | Gesehen am 04.10.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1477-9234 |
| DOI: | 10.1039/C6DT02025A |