A multi-target caffeine derived rhodium(I) N-heterocyclic carbene complex: evaluation of the mechanism of action
A rhodium(I) and a ruthenium(II) complex with a caffeine derived N-heterocyclic carbene (NHC) ligand were biologically investigated as organometallic conjugates consisting of a metal center and a naturally occurring moiety. While the ruthenium(II) complex was largely inactive, the rhodium(I) NHC com...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
08 Jun 2016
|
| In: |
Dalton transactions
Year: 2016, Jahrgang: 45, Heft: 33, Pages: 13161-13168 |
| ISSN: | 1477-9234 |
| DOI: | 10.1039/C6DT02025A |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/C6DT02025A Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2016/dt/c6dt02025a |
| Verfasserangaben: | Jing-Jing Zhang, Julienne K. Muenzner, Mohamed A. Abu el Maaty, Bianka Karge, Rainer Schobert, Stefan Wölfl and Ingo Ott |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1772288233 | ||
| 003 | DE-627 | ||
| 005 | 20230427055833.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 211004s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1039/C6DT02025A |2 doi | |
| 035 | |a (DE-627)1772288233 | ||
| 035 | |a (DE-599)KXP1772288233 | ||
| 035 | |a (OCoLC)1341421571 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Zhang, Jing-Jing |e VerfasserIn |0 (DE-588)1210714434 |0 (DE-627)1698678193 |4 aut | |
| 245 | 1 | 2 | |a A multi-target caffeine derived rhodium(I) N-heterocyclic carbene complex |b evaluation of the mechanism of action |c Jing-Jing Zhang, Julienne K. Muenzner, Mohamed A. Abu el Maaty, Bianka Karge, Rainer Schobert, Stefan Wölfl and Ingo Ott |
| 264 | 1 | |c 08 Jun 2016 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.10.2021 | ||
| 520 | |a A rhodium(I) and a ruthenium(II) complex with a caffeine derived N-heterocyclic carbene (NHC) ligand were biologically investigated as organometallic conjugates consisting of a metal center and a naturally occurring moiety. While the ruthenium(II) complex was largely inactive, the rhodium(I) NHC complex displayed selective cytotoxicity and significant anti-metastatic and in vivo anti-vascular activities and acted as both a mammalian and an E. coli thioredoxin reductase inhibitor. In HCT-116 cells it increased the reactive oxygen species level, leading to DNA damage, and it induced cell cycle arrest, decreased the mitochondrial membrane potential, and triggered apoptosis. This rhodium(I) NHC derivative thus represents a multi-target compound with promising anti-cancer potential. | ||
| 700 | 1 | |a Muenzner, Julienne K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Maaty, Mohamed A. Abu el |e VerfasserIn |4 aut | |
| 700 | 1 | |a Karge, Bianka |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schobert, Rainer |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wölfl, Stefan |d 1959- |e VerfasserIn |0 (DE-588)121047458 |0 (DE-627)081052618 |0 (DE-576)260692360 |4 aut | |
| 700 | 1 | |a Ott, Ingo |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Dalton transactions |d Cambridge : Royal Society of Chemistry, 2003 |g 45(2016), 33, Seite 13161-13168 |h Online-Ressource |w (DE-627)268759146 |w (DE-600)1472887-4 |w (DE-576)077609883 |x 1477-9234 |7 nnas |a A multi-target caffeine derived rhodium(I) N-heterocyclic carbene complex evaluation of the mechanism of action |
| 773 | 1 | 8 | |g volume:45 |g year:2016 |g number:33 |g pages:13161-13168 |g extent:8 |a A multi-target caffeine derived rhodium(I) N-heterocyclic carbene complex evaluation of the mechanism of action |
| 856 | 4 | 0 | |u https://doi.org/10.1039/C6DT02025A |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://pubs.rsc.org/en/content/articlelanding/2016/dt/c6dt02025a |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20211004 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 121047458 |a Wölfl, Stefan |m 121047458:Wölfl, Stefan |d 160000 |d 160100 |e 160000PW121047458 |e 160100PW121047458 |k 0/160000/ |k 1/160000/160100/ |p 6 | ||
| 999 | |a KXP-PPN1772288233 |e 398364306X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"08 Jun 2016","dateIssuedKey":"2016"}],"physDesc":[{"extent":"8 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title":"A multi-target caffeine derived rhodium(I) N-heterocyclic carbene complex","subtitle":"evaluation of the mechanism of action","title_sort":"multi-target caffeine derived rhodium(I) N-heterocyclic carbene complex"}],"name":{"displayForm":["Jing-Jing Zhang, Julienne K. Muenzner, Mohamed A. Abu el Maaty, Bianka Karge, Rainer Schobert, Stefan Wölfl and Ingo Ott"]},"language":["eng"],"relHost":[{"corporate":[{"display":"Royal Society of Chemistry","role":"isb","roleDisplay":"Herausgebendes Organ"}],"note":["Gesehen am 30.01.25"],"recId":"268759146","id":{"issn":["1477-9234"],"zdb":["1472887-4"],"eki":["268759146"]},"disp":"A multi-target caffeine derived rhodium(I) N-heterocyclic carbene complex evaluation of the mechanism of actionDalton transactions","title":[{"title_sort":"Dalton transactions","subtitle":"a journal of inorganic chemistry, including bioinorganic, organometallic, and solid-state chemistry","title":"Dalton transactions"}],"name":{"displayForm":["Royal Society of Chemistry"]},"language":["eng"],"pubHistory":["2003, issue 1 (2003)-"],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"extent":"8","volume":"45","pages":"13161-13168","text":"45(2016), 33, Seite 13161-13168","year":"2016","issue":"33"},"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedKey":"2003","publisher":"Royal Society of Chemistry","dateIssuedDisp":"2003-","publisherPlace":"Cambridge"}]}],"person":[{"given":"Jing-Jing","role":"aut","roleDisplay":"VerfasserIn","display":"Zhang, Jing-Jing","family":"Zhang"},{"roleDisplay":"VerfasserIn","role":"aut","family":"Muenzner","display":"Muenzner, Julienne K.","given":"Julienne K."},{"role":"aut","roleDisplay":"VerfasserIn","display":"Maaty, Mohamed A. Abu el","family":"Maaty","given":"Mohamed A. Abu el"},{"given":"Bianka","role":"aut","roleDisplay":"VerfasserIn","display":"Karge, Bianka","family":"Karge"},{"family":"Schobert","display":"Schobert, Rainer","role":"aut","roleDisplay":"VerfasserIn","given":"Rainer"},{"given":"Stefan","roleDisplay":"VerfasserIn","role":"aut","display":"Wölfl, Stefan","family":"Wölfl"},{"given":"Ingo","display":"Ott, Ingo","family":"Ott","roleDisplay":"VerfasserIn","role":"aut"}],"recId":"1772288233","id":{"doi":["10.1039/C6DT02025A"],"eki":["1772288233"]},"note":["Gesehen am 04.10.2021"]} | ||
| SRT | |a ZHANGJINGJMULTITARGE0820 | ||